Imunofan dosing & administration
Synthetic hexapeptide derived from thymopoietin with immunomodulatory, antioxidant, and hepatoprotective properties
Written by Michael Carroll — Owner, Director of Research · Reviewed by the Peptide Initiative Research Team · Editorial standards
Dosing
How much do I take?
Subcutaneous: A small injection into the fatty layer just under the skin — the same way insulin is given.
Bioavailability High — most of the dose reaches your bloodstream, just more gradually than an IV.
45 mcg per dose
Frequency
Once daily or every other day
Duration
Course of 5-15 injections (about 10-30 days)
Timing
Best time to take
Administer Imunofan at the same time each day (or on the same day each week for weekly injections). Many users prefer morning or evening administration. Pick a time you'll remember consistently.
With food?
Imunofan injections can be given regardless of meal timing. However, if GI effects occur, administering on an empty stomach or with a light meal may help reduce discomfort.
If stacking
Imunofan should be used as directed by your healthcare provider. If combining with other medications or supplements, discuss potential interactions with your provider. Avoid combining with compounds that have overlapping mechanisms unless specifically guided by a medical professional.
Adjusting your dose
Increase if
- Your healthcare provider determines that a longer course (beyond 15 injections) is needed based on immune parameter monitoring
- You are undergoing extended chemotherapy and need sustained immune support
- Your condition involves severe immunodepression requiring more intensive treatment
Decrease if
- You experience persistent injection site reactions — consider switching to nasal spray or suppository form
- You show signs of excessive immune activation (fever, malaise)
- Your immune parameters have normalized and maintenance rather than intensive therapy is appropriate
Signs of right dose
- Noticeable improvement in target symptoms
- Good tolerance with minimal side effects
- Consistent positive response between doses
- Improved lab markers or clinical assessments (if applicable)
Administration
How do I use it?
Reconstitution
What you need
Injection
Route
Subcutaneous injection (into the fatty tissue just under the skin)—allows for consistent absorption and can be self-administered at home after proper training
Best sites
Storage
Before reconstitution
Store Imunofan in the refrigerator at 36-46°F (2-8°C) in its original packaging. Protect from light and moisture. Do not freeze. Check the expiration date before use. Some formulations may be stored at room temperature for limited periods—check your specific product labeling.
After reconstitution
Once reconstituted, Imunofan should be kept refrigerated at 36-46°F (2-8°C) and used within the timeframe specified on your product labeling (typically 14-28 days). Label the vial with the reconstitution date. Do not use if the solution appears cloudy, discolored, or contains particles.
Signs of degradation — discard the vial
Sample daily schedule
As prescribed (once daily)
As prescribed by your healthcare provider injection
Site: Subcutaneous injection—rotate sites if applicable
Maintain a consistent schedule for optimal results with Imunofan. Set reminders if needed. If you miss a dose, follow your healthcare provider's instructions—do not double up on doses to compensate.
Safety
Is it safe?
Side effects
Commonly reported: Injection site reaction, Transient headache, Nasal irritation (intranasal form), Transient mild fever, Mild fatigue, Gastrointestinal discomfort (suppository form)
Less common: Allergic reaction
Stop and seek help if
- Severe or worsening side effects that don't improve with dose adjustment or supportive care
- Signs of an allergic reaction—rash, hives, swelling, or difficulty breathing
- Your healthcare provider recommends discontinuation based on your clinical response
- Development of any new medical condition that may be contraindicated with Imunofan
- Pregnancy or planning to become pregnant (unless specifically approved for use during pregnancy)
- Abnormal lab results or clinical markers that suggest adverse effects
Imunofan should only be started, adjusted, or discontinued under medical supervision. This information is for educational purposes only and does not replace professional medical advice. Never stop a prescribed treatment without consulting your healthcare provider first, as abrupt discontinuation may have consequences.
Flagged pairings
- Immunosuppressants (cyclosporine, tacrolimus) — Imunofan's immune-restoring effects may counteract the intended immunosuppression. Avoid concurrent use or use only with careful medical monitoring.
Published research
What the studies show
Lebedev VV, Pokrovskii VI · 1999
Scientists engineered Imunofan by modifying a natural immune hormone, creating a super-powered version that restores immune cells and boosts the body's infection-fighting bacteria-killing system. The peptide also quiets dangerous inflammation chemicals and strengthens the body's antioxidant defenses, meaning it's valuable for cancer patients enduring radiation and chemotherapy damage.
Sawicka J, Dzierżyńska M, Wardowska A · 2020
Imunofan turbo-charged skin cells to divide 30-50% faster without poisoning them, and when injuries were made on mice ears, the peptide accelerated healing by up to 36%. The peptide essentially flipped a genetic switch in stem cells, activating immune genes that help the body repair damaged tissue.
Lebedev VV, Shamsheva OV · 2007
Imunofan is 1,000 times more powerful than other drugs at blocking the pumps that cancer cells use to pump out chemotherapy before it kills them. This discovery makes Imunofan a potential game-changer for overcoming drug resistance in difficult-to-treat cancers.
Pisarev VM, Tutel'ian AV, Danilina AV · 1995
Imunofan silences the body's inflammatory alarm system within just 2-8 hours by creating special immune cells that release chemical brake pads that slow down tumor necrosis factor, the main chemical messenger of destructive inflammation. This elegant mechanism allows the immune system to fight germs without burning down the tissue around them.
Bionox / Russian pharmacopeia product labeling · 2020
Injectable dose is 45 mcg subcutaneously or intramuscularly once daily/every other day in courses; intranasal spray delivers 50 mcg per dose, one dose per nostril once or twice daily for 8-15 days.
NPP Bionox; Vidal Russia · 2026
Official Russian label: action develops in three phases — fast (starts at 2-3 hours, lasts 2-3 days) with detoxification and antioxidant protection via stimulation of ceruloplasmin, lactoferrin and catalase; middle (from day 2-3, lasting 7-10 days) with enhanced phagocytosis and intracellular destruction of bacteria and viruses; slow (from day 7-10, lasting up to 4 months) with restoration of impaired cellular and humoral immunity and increased specific antibody production. Contraindicated under 2 years of age and in pregnancy; listed adverse effect is allergic reactions. Indications include chronic viral hepatitis, brucellosis, opportunistic and HIV-associated infections.
NPP Bionox · 2026
The developer states Imunofan is a synthetic analogue of the thymic peptide hormone thymopoietin, has been on the Russian pharmaceutical market for more than 25 years, and is permitted for children from two years of age.
Head to head
Imunofan compared
Want the full picture?
The complete Imunofan research profile: mechanism of action, clinical studies, effectiveness timeline, and FAQ.