Immune Protocol
Immunoxel (Dzherelo)Complete dosing & administration guide
Ukrainian botanical immunomodulator that supercharges tuberculosis treatment and restores immune function in HIV patients
Written & reviewed by Michael Carroll · Research, Peptide Initiative
Dose Range
30-50drops
Frequency
Multiple times daily
Route
Oral (liquid drops)
Cycle Length
8-12 weeks
Dosing
How much
do I take?
Oral: Taken by mouth as a capsule, tablet, or liquid.
Bioavailability Varies by compound — many peptides are largely broken down in the gut, so little reaches the blood intact; some small molecules absorb well.
Timing
Best time to take
Morning and evening doses, spaced approximately 12 hours apart
With food?
Can be taken with or without food; sublingual lozenges dissolve under the tongue regardless of meals
If stacking
Take alongside standard TB medications as prescribed; no timing conflicts with anti-TB drugs reported in clinical trials
Adjusting Your Dose
Increase if
- +Well-tolerated at starting dose after 1-2 weeks with no GI issues
- +Sputum conversion has not occurred after 4 weeks of standard therapy
- +Healthcare provider recommends advancing to combination protocol with Anemin
Decrease if
- -Experiencing persistent gastrointestinal discomfort
- -Mild allergic symptoms appear (skin rash, itching)
- -Nausea that doesn't resolve within the first few days
Signs of right dose
- ✓Sputum smear conversion to negative within 1-2 months
- ✓Weight gain and improved appetite
- ✓Reduced fever and improved energy levels
- ✓Rising CD4+ T-cell counts on blood tests (in HIV patients)
Dosing Calculator
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Administration
How do I
use it?
Reconstitution
What you need
- •Immunoxel liquid bottle (original sealed)
- •Clean measuring dropper or pipette
- •Small glass of water (if not taking drops directly)
Injection
Route
N/A — Immunoxel is taken orally or sublingually, NOT by injection
Best sites
- •Under the tongue (sublingual — for lozenges and pastilles)
- •Swallowed with water (oral — for liquid drops)
Technique
- 1.For liquid: Count prescribed drops into a small glass of water, or place drops directly under the tongue
- 2.For sublingual lozenges: Place one lozenge under your tongue and let it dissolve completely — do not chew or swallow whole
- 3.Take at approximately the same times each day for best results
- 4.Continue taking alongside all prescribed TB/HIV medications as directed by your doctor
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
Immunoxel has demonstrated a favorable safety profile across multiple clinical trials involving hundreds of patients with TB and TB/HIV coinfection. No serious adverse events have been reported in published studies. It is approved by Ukraine's Ministry of Health and has been used clinically since the late 1980s. Side effects are generally mild and gastrointestinal in nature.
Safety data comes from Phase 2 and Phase 3 clinical trials conducted primarily in Ukraine, along with a 2021 systematic review and meta-analysis of 6 clinical trials. While evidence is encouraging, most studies are open-label and larger double-blind randomized trials are still needed to fully establish safety in diverse populations.
Common Side Effects
Experienced by some users
Well-tolerated in most patients
Clinical trials consistently report that most patients experience no significant adverse effects from Immunoxel when taken as directed alongside standard medications.
Management: Simply follow the prescribed dosing schedule and report any unusual symptoms to your healthcare provider.
Mild gastrointestinal discomfort
Some patients report mild stomach upset, bloating, or nausea, especially when starting the liquid formulation. This is likely due to the alcohol-based extract.
Management: Take with food or a small glass of water. Symptoms usually resolve within the first few days. Switch to sublingual formulation if GI issues persist.
Less Common
- •Temporary taste changes
- •Mild allergic skin reactions
- •Mild headache
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Signs of allergic reaction (widespread rash, swelling, difficulty breathing)
- ×Persistent gastrointestinal problems that don't resolve within a week
- ×Your doctor advises discontinuation due to medication interactions
- ×Completion of your TB treatment course (Immunoxel is typically used for the duration of TB therapy)
- ×Worsening of symptoms despite continued use (consult your medical team)
Always consult your healthcare provider before starting or stopping Immunoxel. This product should only be used as an adjunct to standard medical treatment, never as a replacement. It is not FDA approved and is primarily available in Ukraine.
Interactions
With other peptides
- ✓Thymalin - Different mechanism (thymic peptide vs botanical); no known conflict; theoretically complementary immune support
- ✓Thymosin Alpha 1 - Both support immune function through different pathways; no interaction data available
- ✓Imunofan - Both are immunomodulators; combining may have additive effects; consult healthcare provider
With medications
- ✓Anti-TB drugs (isoniazid, rifampicin, pyrazinamide, ethambutol) - Safe and beneficial combination — this is the primary intended use; all clinical trials used this combination
- ✓Antiretroviral therapy (ARVs) - Clinical trials showed favorable results combining Immunoxel with ART; however, St. John's Wort content may affect some ARV levels — discuss with doctor
- !Immunosuppressants - May counteract immunosuppressive effects; avoid combining without specialist guidance
- !Warfarin and blood thinners - Some herbal components may affect coagulation; monitor INR closely
- !Oral contraceptives - St. John's Wort in the formulation may reduce effectiveness of hormonal birth control
With supplements
- ✓Vitamin D - Complementary immune support; both beneficial in TB treatment; safe combination
- ✓Zinc - Both support immune function; no known interactions; safe together
- ✓Anemin (herbal phytoconcentrate) - Specifically studied in combination with Immunoxel; synergistic cytokine modulation
- ✓Probiotics - Both support immune health; may help with any GI side effects from the herbal extract
Published Research
What the studies show
Hariyanto TI et al. · 2021
When researchers combined data from 6 TB studies involving nearly 500 patients, Immunoxel boosted the power of standard TB drugs by more than threefold, making patients three times more likely to clear the infection. The herbal supplement also dramatically reduced fevers while helping the body fight back against the bacteria.
Efremenko YV, Arjanova OV, Prihoda ND et al. · 2012
TB patients who let Immunoxel dissolve under their tongue cleared their lungs at a rate of 84% in just one month, versus only 19% in patients taking placebo. Remarkably, the herbal helper worked equally well regardless of age, weight, gender, or whether the TB was drug-resistant or combined with HIV.
Arjanova OV, Prihoda ND, Yurchenko LV et al. · 2009
In patients suffering from both TB and HIV, adding Immunoxel to standard TB drugs quadrupled their chances of clearing the infection (from 16% to 67%) and cut secondary infections from 12 down to 3. Patients also gained nearly 6 pounds, reversing the severe weight loss typical of dual infection.
Nikolaeva LG, Maystat TV, Masyuk LA et al. · 2009
The herbal extract Immunoxel alone—without any antiretroviral drugs—expanded patients' HIV-fighting CD4 cells by 71%, jumping from 174 to 283 cells in just 2 months and reducing HIV copies in 70% of those treated. This suggests the botanical blend awakens the immune system's dormant power.
Nikolaeva LG, Maystat TV, Pylypchuk VS et al. · 2008
Immunoxel works by tuning the immune orchestra—ramping up the protective chemical signals IL-2 and interferon-gamma by 61%, while silencing the inflammatory alarm bells TNF-alpha. This immune rebalancing allows the body to mount an effective counterattack against tuberculosis.
Head to Head
Immunoxel (Dzherelo) compared
Want the Full Picture?
View the complete Immunoxel (Dzherelo) research profile including mechanism of action, clinical studies, effectiveness timeline, and FAQ.