Growth Hormone Protocol
AlexamorelinComplete Dosing & Administration Guide
A next-generation growth hormone releaser that converts to hexarelin in your body for enhanced GH, cortisol, and unique aldosterone stimulation.
Dose Range
100-300mcg
Frequency
Multiple times daily
Route
Subcutaneous injection
Cycle Length
4-6 weeks
Dosing
How much
do I take?
Timing
Best time to take
Morning injection on empty stomach 30-60 minutes before food maximizes GH response; second dose in late afternoon if dosing twice daily
With food?
Separate from large meals by at least 30-60 minutes; food delays or blunts response. Light snack acceptable 2+ hours after injection
If stacking
If stacking with GHRH, inject GHRH 5-10 minutes after alexamorelin for synergistic effect. Avoid other GHS compounds on same day
Adjusting Your Dose
Increase if
- +No noticeable GH response after 5-7 days at starting dose
- +Already using similar compounds and tolerated well
- +Aiming for aggressive muscle-building phase with recovery capacity
Decrease if
- -Excessive hunger interferes with daily life
- -ACTH-related side effects (anxiety, mood changes) emerge
- -Water retention becomes problematic
Signs of right dose
- ✓Increased appetite 1-2 hours post-injection
- ✓Noticeable energy lift and improved sleep quality
- ✓Visible muscle pump and recovery improvement within 1-2 weeks
Dosing Calculator
Calculate Your Exact Dose
Step 1: Peptide Weight
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Administration
How do I
use it?
Reconstitution
What you need
- •Bacteriostatic water or normal saline (typically 1-2 mL per vial)
- •Sterile syringe and needle (25-27 gauge preferred)
- •Alcohol swabs for vial sterilization
- •Sterile vial for storage
Injection
Route
Subcutaneous injection preferred for consistent GH response; intravenous only in clinical/research settings
Best sites
- •Lower abdomen (2 inches from navel, avoiding surrounding area)
- •Upper thigh or lateral thigh
- •Lateral chest wall above waist
- •Upper arm outer tricep area
Technique
- 1.Clean injection site with alcohol swab and let dry 10-15 seconds
- 2.Pinch skin at injection site to create small fold
- 3.Insert needle at 45-90 degree angle (steeper = more subcutaneous, shallower = easier)
- 4.Push plunger slowly to minimize discomfort and ensure proper dispersion
- 5.Withdraw needle, release skin, and apply gentle pressure for 5 seconds
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
Alexamorelin is a research compound with only one small human study (6 subjects), making it much less proven than hexarelin. While it shows promise as a potent GH releaser, the limited human evidence means we don't fully understand long-term effects, optimal dosing in different populations, or rare side effects. Its unique stronger ACTH and aldosterone effects require careful monitoring. Always start low and monitor how your body responds.
This compound has NOT been approved by the FDA and is not available as a pharmaceutical medication. All use is research-based. The single human study was published in 2000 (Eur J Endocrinol), providing our only direct human efficacy data.
Common Side Effects
Experienced by some users
Increased Hunger
Ghrelin receptor activation stimulates appetite, typically 1-3 hours post-injection. Most users report mild to moderate increase.
Management: Time injections around normal meal times or plan snacks accordingly. This side effect usually decreases after 1-2 weeks as your body adapts.
Water Retention
Aldosterone elevation causes sodium and water retention, usually mild to moderate. Can manifest as slight bloating or puffy face.
Management: Maintain hydration and moderate sodium intake. If severe, reduce dose or frequency. Usually resolves within days of stopping.
Injection Site Reactions
Mild redness, itching, or small lumps at injection site. Normal immune response to foreign peptide.
Management: Rotate injection sites to prevent irritation. Use proper sterile technique. Reactions typically fade within hours to days.
Less Common
- •Cortisol-Related Mood Changes
- •Joint or Muscle Aches
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Severe mood changes or anxiety that don't improve with dose adjustment
- ×Signs of cardiovascular stress (chest pain, irregular heartbeat, severe headaches)
- ×Uncontrolled blood sugar elevation or worsening of diabetes
- ×Persistent allergic reactions or injection site infections
- ×Completion of planned 4-6 week cycle (take break before restarting)
- ×New or worsening joint problems that limit training
This is research compound information, not medical advice. Consult a healthcare provider before starting, especially if you have existing health conditions. Stop immediately if you experience serious side effects and seek medical attention.
Interactions
With other peptides
- ✓Synergistic GH release; inject GHRH 5-10 minutes after alexamorelin for maximum effect
- !Redundant since alexamorelin metabolizes to hexarelin; combining offers no additional benefit and increases side effects
- ✓Complementary for recovery; IGF-1 amplifies growth signaling without competing with alexamorelin's GHS mechanism
- ✓Synergistic for tissue repair; alexamorelin provides systemic GH while BPC-157 targets local healing
With medications
- !Corticosteroids (prednisone, dexamethasone, etc.) - Alexamorelin already elevates cortisol through ACTH; combining risks excessive cortisol with serious metabolic effects
- !Dopamine antagonists (antipsychotics like haloperidol) - May reduce GH response; dopamine pathways influence GHS effectiveness
- !Somatostatin analogs (octreotide) - Directly block GH secretion, completely negating alexamorelin's mechanism
- !Blood pressure medications - Monitor closely; aldosterone elevation may reduce antihypertensive effectiveness
With supplements
- ✓GHRH-boosting supplements (arginine, ornithine) - Synergistic but additive ACTH response; monitor cortisol effects carefully
- ✓High-dose electrolyte supplements (sodium, potassium) - Aldosterone elevation already increases sodium retention; excess supplementation risks dangerous electrolyte imbalance
- ✓Sleep aids or melatonin - Compatible; actually beneficial since quality sleep amplifies GH response
Want the Full Picture?
View the complete Alexamorelin research profile including mechanism of action, clinical studies, effectiveness timeline, and FAQ.
View Full Alexamorelin Profile