Hexarelin
His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Hexarelin is a synthetic hexapeptide belonging to the growth hormone releasing peptide (GHRP) family and is recognized as one of the most potent growth hormone secretagogues available. It binds to ghrelin receptors (GHS-R) in the hypothalamus and pituitary gland, triggering powerful growth hormone release and providing unique cardiovascular protective benefits beyond other GHRPs.
Complete Research Database
Dual Receptor Mechanism (GIP/GLP-1)
GLP-1 Receptor Pathway
- •Increases insulin secretion (glucose-dependent)
- •Suppresses glucagon release
- •Slows gastric emptying
- •Enhances satiety in hypothalamus
- •Preserves beta-cell function
GIP Receptor Pathway
- •Enhances insulin secretion (stronger than GLP-1)
- •Promotes fat oxidation
- •Improves insulin sensitivity in muscle
- •Reduces hepatic glucose production
- •Modulates adipose tissue metabolism
Why Dual Agonism is Superior
Hexarelin binds with high affinity to ghrelin receptors (GHS-R1a) located in the hypothalamic arcuate nucleus and pituitary somatotroph cells. This binding activates adenylyl cyclase, increasing intracellular cAMP levels and triggering calcium-dependent growth hormone release. Unlike other GHRPs, Hexarelin also demonstrates direct cardioprotective effects through endothelial nitric oxide synthase activation and improved cardiac contractility.
Pharmacokinetic Profile
Top 10 High-Quality Research Articles
Medical Disclaimer
Hexarelin is a research chemical not approved by the FDA for human use. This information is for educational purposes only and should not replace professional medical advice. Always consult with a qualified healthcare provider before starting any peptide therapy. Individual results may vary. Not suitable for use by minors, pregnant or nursing women, or individuals with certain medical conditions.