Peptide Comparison
Tripeptide-29vsPalmitoyl Tripeptide-1
The minimal collagen-mimetic tripeptide (Gly-Pro-Hyp) that stimulates fibroblast collagen synthesis and resists photoaging.
Collagen-stimulating matrikine peptide and key component of Matrixyl 3000 for comprehensive anti-aging skin renewal.
At a Glance
Quick
comparison
Dose Range
Tripeptide-29
0.5%–2% %
Palmitoyl Tripeptide-1
0.5%–3% %
Frequency
Tripeptide-29
Once daily
Palmitoyl Tripeptide-1
Once daily
Administration
Tripeptide-29
Topical
Palmitoyl Tripeptide-1
Topical
Cycle Length
Tripeptide-29
Ongoing/indefinite
Palmitoyl Tripeptide-1
Ongoing/indefinite
Onset Speed
Tripeptide-29
Moderate (1-2 weeks)
Palmitoyl Tripeptide-1
Moderate (1-2 weeks)
Evidence Level
Tripeptide-29
Limited human trials
Palmitoyl Tripeptide-1
Limited human trials
Efficacy
Benefit
ratings
Collagen Synthesis
Anti-Photoaging
Skin Hydration
Collagen Production
Anti-Aging
Skin Firmness
Technical Data
Compound
specifications
Tripeptide-29
Molecular Formula
C12H19N3O5
Molecular Weight
285.3 Da
Half-Life
Oral: rapidly metabolized to Pro-Hyp; accumulates in skin tissue over hours; topical: sustained local activity
Bioavailability
4.4% absolute oral bioavailability; transporter-mediated intestinal absorption; preferential skin tissue accumulation
CAS Number
2239-67-0
Palmitoyl Tripeptide-1
Molecular Formula
C30H54N6O5
Molecular Weight
578.8 Da
Half-Life
Limited data; peptide is susceptible to enzymatic degradation in skin but palmitoylation improves stability compared to unmodified GHK
Bioavailability
Enhanced topical penetration via palmitoyl lipid modification; reaches dermis where fibroblasts reside
CAS Number
147732-56-7
Applications
Best
suited for
Tripeptide-29
Individuals seeking evidence-based collagen supplementation for skin health
Tripeptide-29 is particularly well-suited for individuals focused on individuals seeking evidence-based collagen supplementation for skin health. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Those with photoaged skin from chronic sun exposure
Tripeptide-29 is particularly well-suited for individuals focused on those with photoaged skin from chronic sun exposure. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
People wanting to support skin hydration and elasticity from both oral and topical routes
Tripeptide-29 is particularly well-suited for individuals focused on people wanting to support skin hydration and elasticity from both oral and topical routes. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Users looking for a collagen-mimetic peptide with clinical trial data supporting efficacy
Tripeptide-29 is particularly well-suited for individuals focused on users looking for a collagen-mimetic peptide with clinical trial data supporting efficacy. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Palmitoyl Tripeptide-1
Individuals seeking comprehensive collagen stimulation through topical skincare
Palmitoyl Tripeptide-1 is particularly well-suited for individuals focused on individuals seeking comprehensive collagen stimulation through topical skincare. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Those with aging skin showing loss of firmness, elasticity, and density
Palmitoyl Tripeptide-1 is particularly well-suited for individuals focused on those with aging skin showing loss of firmness, elasticity, and density. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
People looking for non-invasive alternatives to injectable collagen treatments
Palmitoyl Tripeptide-1 is particularly well-suited for individuals focused on people looking for non-invasive alternatives to injectable collagen treatments. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Those seeking GHK-based skin benefits without copper peptide formulation complexity
Palmitoyl Tripeptide-1 is particularly well-suited for individuals focused on those seeking ghk-based skin benefits without copper peptide formulation complexity. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Safety Profile
Side
effects
Tripeptide-29
Common
- Mild Gastrointestinal Adjustment
- Aftertaste (oral)
- Mild Skin Warmth (topical)
- Initial Skin Purging
Uncommon
- Allergic Sensitivity
Serious
- Anaphylaxis (theoretical)
- Limited Bioavailability and Potential Immunogenicity
Palmitoyl Tripeptide-1
Common
- Temporary Skin Irritation
- Mild Redness
- Dryness
- Mild Peeling
Uncommon
- Contact Dermatitis
Serious
- Skin Sensitization from Fragmented Peptide
Research Status
Safety
& evidence
Tripeptide-29
Evidence Level
Limited human trials
FDA Status
Research compound
Safety Overview
Tripeptide-29 (Gly-Pro-Hyp, glycyl-prolyl-hydroxyproline) is a naturally occurring collagen-derived tripeptide with an excellent cosmetic safety profile. This is the fundamental repeat unit of collagen protein, making it highly biocompatible. Both oral and topical forms demonstrate minimal adverse effects in clinical trials. No serious adverse events have been reported in published clinical studies spanning over 15 years. The tripeptide is generally recognized as safe (GRAS) for both topical and oral use by regulatory authorities. Individual responses are generally benign and limited to mild gastrointestinal adjustment with oral supplementation or transient dermal warmth with topical application. The primary safety consideration is allergenicity in individuals with gelatin or collagen allergies, which is rare but requires awareness. Molecular weight (285.3 Da) ensures limited systemic absorption when applied topically.
Contraindications
- xKnown allergy to collagen, gelatin, or animal-derived protein products
- xActive skin infections or dermatitis at the topical application site
- xHypersensitivity to hydroxyproline-containing peptides
- xConcurrent use with products at extreme pH that may hydrolyze the peptide
Palmitoyl Tripeptide-1
Evidence Level
Limited human trials
FDA Status
Research compound
Safety Overview
Palmitoyl tripeptide-1 demonstrates excellent cosmetic safety with GRAS/safe-for-use designation in topical formulations at concentrations up to 2%. No serious adverse events in 20+ years of cosmetic industry use; mild erythema (<1% of subjects) at high concentrations (>5%). Dermal penetration limited to stratum corneum; no systemic absorption in vitro. Compatible with common skincare ingredients.
Contraindications
- xKnown hypersensitivity to palmitoyl tripeptide-1 or related peptide ingredients
- xActive skin infections or severely compromised skin barrier at application site
- xOpen wounds or actively inflamed dermatitis in treatment area
- xNo known systemic contraindications for topical cosmetic use
Decision Guide
Which is
right for you?
Choose Tripeptide-29 if...
- Individuals seeking evidence-based collagen supplementation for skin health
- Those with photoaged skin from chronic sun exposure
- People wanting to support skin hydration and elasticity from both oral and topical routes
- Users looking for a collagen-mimetic peptide with clinical trial data supporting efficacy
Choose Palmitoyl Tripeptide-1 if...
- Individuals seeking comprehensive collagen stimulation through topical skincare
- Those with aging skin showing loss of firmness, elasticity, and density
- People looking for non-invasive alternatives to injectable collagen treatments
- Those seeking GHK-based skin benefits without copper peptide formulation complexity