Cognitive Protocol
CerlutenComplete Dosing & Administration Guide
Brain-derived peptide bioregulator complex containing AED, KED, AEDG, and KE peptides that promote neurogenesis through histone binding, restore dendritic spine architecture under neurotoxic conditions, and enhance cognitive recovery in stroke and brain injury patients
Dose Range
10-20mg
Frequency
Once daily
Route
Oral (capsule)
Cycle Length
8-12 weeks
Dosing
How much
do I take?
Starting Dose
1 capsule (10-20 mg) once daily OR 5-6 sublingual drops 3 times daily
Begin with the standard starting protocol. Capsules are taken before breakfast with water. Sublingual drops (0.25-0.35 mL per dose) are held under the tongue for 1-2 minutes before swallowing, 10-15 minutes before eating. The sublingual form provides faster absorption and bypasses first-pass metabolism. Effects are gradual — allow the full initial period before assessing response.
Standard Dose
1-2 capsules daily OR 5-6 drops 3-4 times daily
Standard clinical protocol for cognitive support and post-stroke recovery. In Russian clinical studies, 1-2 capsules were given 2-3 times daily for 10-20 days with significant EEG and cognitive improvements. Repeat courses every 3-6 months. Can be combined with Pinealon for serotonin/melatonin support or Epithalon for neuroendocrine support. Track cognitive changes using standardized assessments if possible.
Advanced Dose
2 capsules 2-3 times daily
Clinical trial protocol used in the 48-patient CNS disease study at the Saint Petersburg Institute. This higher-frequency regimen produced significant improvements (64.6% of patients) and EEG normalization. Typically reserved for structured clinical protocols under medical supervision. Often combined with other Khavinson bioregulators: Endoluten for neuroendocrine support, Vladonix for immune function, Sigumir for musculoskeletal, Svetinorm for liver, and Ventfort for vasculature.
Timing
Best time to take
Take Cerluten at the same time each day for consistent blood levels. Morning dosing with breakfast is often preferred, but follow your healthcare provider's specific instructions.
With food?
Cerluten can typically be taken with or without food. Taking it with a light meal may help reduce any GI discomfort. Avoid taking with grapefruit juice or high-fat meals unless specifically directed.
If stacking
Cerluten should be used as directed by your healthcare provider. If combining with other medications or supplements, discuss potential interactions with your provider. Avoid combining with compounds that have overlapping mechanisms unless specifically guided by a medical professional.
Adjusting Your Dose
Increase if
- +You've tolerated the current dose for the recommended period without significant side effects
- +Therapeutic goals haven't been met at the current dose level
- +Your healthcare provider recommends dose escalation based on your response
- +Lab work or clinical assessments support a higher dose
Decrease if
- -Side effects are bothersome or impacting daily life despite management strategies
- -You experience any signs of an adverse reaction
- -Lab results indicate the need for dose reduction
- -Your healthcare provider recommends a lower dose based on your response
Signs of right dose
- ✓Therapeutic goals being met with minimal side effects
- ✓Stable and consistent response to treatment
- ✓Lab values or clinical markers trending in the right direction
- ✓Good tolerance with manageable or absent side effects
Dosing Calculator
Calculate Your Exact Dose
Step 1: Peptide Weight
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Administration
How do I
use it?
Reconstitution
What you need
- •Cerluten in its prescribed form
- •Clean, dry storage container
- •Measuring device if applicable (oral syringe, measuring cup)
- •Calendar or reminder app for dosing schedule
Injection
Route
Cerluten is administered Oral (capsule)—no injection required
Best sites
- •Not applicable—this is not an injectable formulation
Technique
- 1.Follow the specific administration instructions for your Cerluten formulation
- 2.Take or apply as directed by your healthcare provider
- 3.Store properly between uses according to package instructions
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
Cerluten is a peptide extract from cerebral tissue of young animals that is not FDA-approved and lacks rigorous clinical safety data. As an undefined mixture of peptides and proteins from animal sources, quality control and batch consistency cannot be guaranteed. Potential risks include allergic reactions to animal-derived proteins, contamination with microbial pathogens or prions, and unknown long-term immunological effects. No comprehensive safety studies have been conducted in humans, and the active pharmaceutical components have never been identified or standardized. The product exists primarily in Russian and Eastern European medical markets without Western regulatory oversight.
Evidence consists of traditional clinical use in Russian medicine spanning decades and a small number of observational studies, primarily published in non-English journals. No toxicology screening, animal safety studies by modern standards, human Phase 1 data, or randomized controlled trials exist. Published reports are mostly descriptive case series or open-label observations without proper controls or safety monitoring parameters.
Common Side Effects
Experienced by some users
Mild headache
Transient headache during the initial days of treatment as brain neurochemistry adjusts to enhanced neuronal gene expression and modified signaling patterns.
Management: Ensure adequate hydration. Usually self-limiting within 3-5 days. Reduce dose temporarily if persistent.
Mild drowsiness
Slight fatigue or drowsiness in the first few days, particularly with the sublingual form, as neuronal activity patterns shift.
Management: Take in the morning or early afternoon. Usually resolves within the first week of use.
Mild GI discomfort
Slight nausea or stomach discomfort with oral capsule administration, common with peptide supplements.
Management: Take capsules with a small amount of food or water. Consider the sublingual form to bypass the GI tract.
Vivid dreams
Enhanced dream vividness reflecting active neuroplasticity and neural reorganization processes stimulated by the peptide complex.
Management: Generally benign and may indicate active neurogenesis. No action typically required.
Less Common
- •Transient sleep pattern changes
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Severe or worsening side effects that don't improve with dose adjustment or supportive care
- ×Signs of an allergic reaction—rash, hives, swelling, or difficulty breathing
- ×Your healthcare provider recommends discontinuation based on your clinical response
- ×Development of any new medical condition that may be contraindicated with Cerluten
- ×Pregnancy or planning to become pregnant (unless specifically approved for use during pregnancy)
- ×Abnormal lab results or clinical markers that suggest adverse effects
Cerluten should only be started, adjusted, or discontinued under medical supervision. This information is for educational purposes only and does not replace professional medical advice. Never stop a prescribed treatment without consulting your healthcare provider first, as abrupt discontinuation may have consequences.
Interactions
With other peptides
- ✓May be used together under medical guidance.
- ✓May be used together under medical guidance.
- ✓May be used together under medical guidance.
With medications
- !Other CNS-active peptide complexes at high doses without medical guidance — potential for overlapping epigenetic effects - Use with caution—discuss with your healthcare provider.
- !Strong sedatives or CNS depressants — may produce additive sedation - Use with caution—discuss with your healthcare provider.
- !Immunosuppressive medications — Cerluten's component peptides have immunomodulatory properties that may interact with immunosuppression - Use with caution—discuss with your healthcare provider.
With supplements
- ✓Multivitamins - Generally safe to take alongside Cerluten. Space doses apart if taking oral formulations to ensure optimal absorption.
- ✓Electrolyte supplements - Helpful if experiencing any GI side effects that could lead to dehydration. Safe to combine.
Want the Full Picture?
View the complete Cerluten research profile including mechanism of action, clinical studies, effectiveness timeline, and FAQ.
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