Peptide Comparison
SYN-AKEvsAcetyl Hexapeptide-3 (Argireline)
Synthetic snake venom-mimetic tripeptide that competitively antagonizes nicotinic acetylcholine receptors for rapid expression wrinkle reduction.
SNARE complex inhibitor that reduces expression wrinkles through topical neuromuscular modulation — the 'Botox in a bottle' peptide.
At a Glance
Quick
comparison
Dose Range
SYN-AKE
1%–4% %
Acetyl Hexapeptide-3 (Argireline)
5%–10% %
Frequency
SYN-AKE
Once daily
Acetyl Hexapeptide-3 (Argireline)
Once daily
Administration
SYN-AKE
Topical
Acetyl Hexapeptide-3 (Argireline)
Topical
Cycle Length
SYN-AKE
Ongoing/indefinite
Acetyl Hexapeptide-3 (Argireline)
Ongoing/indefinite
Onset Speed
SYN-AKE
Moderate (1-2 weeks)
Acetyl Hexapeptide-3 (Argireline)
Moderate (1-2 weeks)
Evidence Level
SYN-AKE
Limited human trials
Acetyl Hexapeptide-3 (Argireline)
Limited human trials
Efficacy
Benefit
ratings
Rapid Wrinkle Reduction
Neuromuscular Specificity
Multi-Target Anti-Aging
Expression Wrinkle Reduction
Non-Invasive Treatment
Safety Profile
Technical Data
Compound
specifications
SYN-AKE
Molecular Formula
C23H37N5O7
Molecular Weight
495.58 Da
Half-Life
Topical application; immediate nAChR antagonism with effects persisting up to 24 hours per application
Bioavailability
Topical dermal penetration sufficient for neuromuscular junction modulation; supplied pre-formulated in glycerin/aqua vehicle
CAS Number
823202-99-9
Acetyl Hexapeptide-3 (Argireline)
Molecular Formula
C35H62N14O11S
Molecular Weight
887.0 Da
Half-Life
Topical stability dependent on formulation; methionine residue susceptible to oxidation; stable at pH 5.5-7.7
Bioavailability
Limited skin penetration (0.22-0.54%); primarily acts at stratum corneum and superficial epidermis; O/W emulsions enhance delivery
CAS Number
616204-22-9
Applications
Best
suited for
SYN-AKE
Individuals seeking rapid-acting topical wrinkle reduction for expression lines
SYN-AKE is particularly well-suited for individuals focused on individuals seeking rapid-acting topical wrinkle reduction for expression lines. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Those wanting to extend or complement botulinum toxin injection results
SYN-AKE is particularly well-suited for individuals focused on those wanting to extend or complement botulinum toxin injection results. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
People with crow's feet, forehead lines, and glabellar wrinkles from muscle movement
SYN-AKE is particularly well-suited for individuals focused on people with crow's feet, forehead lines, and glabellar wrinkles from muscle movement. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Users preferring a well-characterized peptide with defined receptor pharmacology
SYN-AKE is particularly well-suited for individuals focused on users preferring a well-characterized peptide with defined receptor pharmacology. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Acetyl Hexapeptide-3 (Argireline)
Individuals seeking non-invasive reduction of expression lines and dynamic wrinkles
Acetyl Hexapeptide-3 (Argireline) is particularly well-suited for individuals focused on individuals seeking non-invasive reduction of expression lines and dynamic wrinkles. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Those with needle phobia who want botulinum toxin-like effects without injections
Acetyl Hexapeptide-3 (Argireline) is particularly well-suited for individuals focused on those with needle phobia who want botulinum toxin-like effects without injections. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
People targeting crow's feet, forehead lines, and glabellar creases
Acetyl Hexapeptide-3 (Argireline) is particularly well-suited for individuals focused on people targeting crow's feet, forehead lines, and glabellar creases. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Individuals looking for preventive anti-wrinkle treatment to slow expression line formation
Acetyl Hexapeptide-3 (Argireline) is particularly well-suited for individuals focused on individuals looking for preventive anti-wrinkle treatment to slow expression line formation. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Safety Profile
Side
effects
SYN-AKE
Common
- Mild Tingling Sensation
- Temporary Tightening Sensation
- Mild Skin Dryness
- Transient Redness
Uncommon
- Contact Irritation (rare)
Serious
- Allergic Reaction (not reported)
- Anaphylactic Reaction to Snake Peptide Derivative
Acetyl Hexapeptide-3 (Argireline)
Common
- Mild Skin Irritation
- Transient Redness
- Slight Dryness
- Stinging on Compromised Skin
Uncommon
- Contact Dermatitis
Serious
- Allergic Contact Dermatitis
Research Status
Safety
& evidence
SYN-AKE
Evidence Level
Limited human trials
FDA Status
Research compound
Safety Overview
SYN-AKE demonstrates excellent topical tolerability with no serious adverse events reported in cosmetic use spanning 15+ years. Adverse testing including Ames test (genotoxicity) and cytotoxicity assays show negative results at therapeutic concentrations, confirming absence of mutagenic or cellular toxicity potential. Occasional mild tingling or slight dryness represents expected local skin responses rather than true adverse effects; systemic absorption is negligible due to peptide topical application mechanism.
Contraindications
- xKnown hypersensitivity to Dipeptide Diaminobutyroyl Benzylamide Diacetate or excipients
- xActive skin infections or significant dermatitis at intended application sites
- xSevere compromised skin barrier in the treatment area
- xConcurrent use with products at pH above 7.5 that may destabilize the peptide
Acetyl Hexapeptide-3 (Argireline)
Evidence Level
Limited human trials
FDA Status
Research compound
Safety Overview
Acetyl Hexapeptide-3 demonstrates an excellent safety profile for topical cosmetic use with no serious adverse events reported in clinical studies. At the 10% concentrations used in cosmetic formulations, systemic absorption is minimal and no neurotoxicity has been observed despite its mechanism of action on the neuromuscular junction. The peptide shows a safety margin of approximately 100-fold compared to toxic reference compounds. Primary concerns are limited to local skin irritation in sensitive individuals, such as mild erythema, transient stinging, or contact dermatitis in those with peptide hypersensitivity.
Contraindications
- xKnown hypersensitivity to acetyl hexapeptide-3 or formulation components
- xActive skin infections or open wounds at the application site
- xNo known systemic contraindications at cosmetic concentrations
- xUse with caution in individuals with neuromuscular disorders (theoretical concern)
Decision Guide
Which is
right for you?
Choose SYN-AKE if...
- Individuals seeking rapid-acting topical wrinkle reduction for expression lines
- Those wanting to extend or complement botulinum toxin injection results
- People with crow's feet, forehead lines, and glabellar wrinkles from muscle movement
- Users preferring a well-characterized peptide with defined receptor pharmacology
Choose Acetyl Hexapeptide-3 (Argireline) if...
- Individuals seeking non-invasive reduction of expression lines and dynamic wrinkles
- Those with needle phobia who want botulinum toxin-like effects without injections
- People targeting crow's feet, forehead lines, and glabellar creases
- Individuals looking for preventive anti-wrinkle treatment to slow expression line formation