Peptide Comparison
SM-130686vsGHRP-6 (Growth Hormone Releasing Peptide-6)
Experimental oral growth hormone secretagogue with anabolic potential from preclinical research
A synthetic hexapeptide that signals your pituitary to release growth hormone through a unique pathway, with emerging evidence of heart-protective benefits.
At a Glance
Quick
comparison
Dose Range
SM-130686
5–20 mg
GHRP-6 (Growth Hormone Releasing Peptide-6)
100–300 mcg
Frequency
SM-130686
Multiple times daily
GHRP-6 (Growth Hormone Releasing Peptide-6)
Multiple times daily
Administration
SM-130686
Oral capsule or powder
GHRP-6 (Growth Hormone Releasing Peptide-6)
Subcutaneous injection
Cycle Length
SM-130686
8-12 weeks
GHRP-6 (Growth Hormone Releasing Peptide-6)
8-12 weeks
Onset Speed
SM-130686
Moderate (1-2 weeks)
GHRP-6 (Growth Hormone Releasing Peptide-6)
Moderate (1-2 weeks)
Evidence Level
SM-130686
Moderate human trials (Phase 1-2)
GHRP-6 (Growth Hormone Releasing Peptide-6)
Limited human trials
Efficacy
Benefit
ratings
Muscle and Strength
Recovery and Performance
Metabolic Health
Muscle Recovery and Growth
Cellular Health and Protection
Appetite and Nutrient Intake
Technical Data
Compound
specifications
SM-130686
Molecular Formula
C22H24Cl2F3N3O3
Molecular Weight
506.3 g/mol (as HCl salt)
Half-Life
Not published in humans (preclinical only)
Bioavailability
28% in rats (oral administration)
CAS Number
259667-25-9
GHRP-6 (Growth Hormone Releasing Peptide-6)
Molecular Formula
C46H56N12O6
Molecular Weight
873.0 g/mol
Half-Life
~2.5 hours
Bioavailability
<1% oral, high subcutaneous
CAS Number
87616-84-0
Protocols
Dosing
tiers
SM-130686
GHRP-6 (Growth Hormone Releasing Peptide-6)
Applications
Best
suited for
SM-130686
Lean Mass Building in Trained Athletes
SM-130686 targets GHS-R to stimulate GH release, which supports anabolic processes. Preclinical studies in rats showed significant increases in fat-free mass and body weight when combined with resistance training principles.
Age-Related GH Decline
As a GHS-R agonist, SM-130686 may help restore physiological GH secretion in adults experiencing age-related decline. The oral route is convenient for long-term administration.
Recovery and Performance
GH supports tissue repair, collagen synthesis, and recovery. May benefit individuals engaged in intensive resistance training or athletic performance work.
GHRP-6 (Growth Hormone Releasing Peptide-6)
Athletes and Serious Trainers
If you're hitting the gym hard and want better recovery and muscle growth, GHRP-6 amplifies your body's natural GH response. This is particularly valuable during intense training phases when you want to maximize adaptation and minimize soreness. The appetite stimulation also helps you consume the calories you need to grow.
Those Exploring Novel Peptide Protocols
GHRP-6 offers a unique mechanism through the ghrelin receptor, making it valuable for users who want to explore diverse GH-stimulation pathways. It works distinctly from GHRH-based approaches and pairs well with other GH secretagogues for synergistic effects.
Longevity and Metabolic Health Enthusiasts
Growth hormone plays roles in metabolic health, body composition, and potentially aging markers. GHRP-6's emerging research on cellular protection and antioxidant activation makes it interesting for those interested in broader health optimization beyond just muscle growth.
Safety Profile
Side
effects
SM-130686
Common
- Appetite stimulation
- Transient water retention
Uncommon
- Joint or muscle aches
- Transient changes in blood glucose
Serious
- Potential carpal tunnel syndrome
- Unknown effects on tumor growth
GHRP-6 (Growth Hormone Releasing Peptide-6)
Common
- Increased Appetite
- Mild Joint or Muscle Discomfort
- Water Retention or Mild Swelling
Uncommon
- Sleep Disturbances
- Mild Dizziness or Lightheadedness
Serious
- Allergic Reaction
Research Status
Safety
& evidence
SM-130686
Evidence Level
Moderate human trials (Phase 1-2)
FDA Status
Research compound
Safety Overview
SM-130686 is a research compound that has never been tested in humans. All safety and efficacy data come from animal studies (primarily rats). No human clinical trials have been conducted. Use carries unknown risks. Potential side effects based on GH physiology and limited preclinical work.
Contraindications
- xPregnancy or breastfeeding (no safety data)
- xActive cancer (GH stimulation may be contraindicated)
- xUncontrolled diabetes (may affect glucose metabolism)
- xSevere cardiovascular disease (GH effects on heart not fully characterized)
GHRP-6 (Growth Hormone Releasing Peptide-6)
Evidence Level
Limited human trials
FDA Status
Research compound
Safety Overview
GHRP-6 has a relatively long research history dating back to 1981, with human studies demonstrating its ability to stimulate GH release. The good news is that animal safety studies show excellent tolerability at high doses, and the side effects reported are generally mild and reversible. However, it's not FDA-approved, so use is based on research evidence rather than pharmaceutical oversight. Always purchase from reputable sources and consider medical consultation, especially if you have existing health conditions.
Contraindications
- xKnown allergy or sensitivity to any component of the peptide
- xActive cancer or history of cancer without medical clearance
- xSevere cardiovascular disease or uncontrolled hypertension
- xAcute critical illness or sepsis
Decision Guide
Which is
right for you?
Choose SM-130686 if...
- Lean mass building (theoretical)
- Strength development (preclinical evidence)
- Body composition improvement (animal studies)
Choose GHRP-6 (Growth Hormone Releasing Peptide-6) if...
- Building lean muscle mass and improving body composition
- Recovery from intense training programs and athletic performance
- Supporting overall metabolic health and longevity markers
- Exploring novel GH-stimulation pathways for those who respond well to peptide protocols