Peptide Comparison
SM-130686vsCJC-1295 (No DAC)
Experimental oral growth hormone secretagogue with anabolic potential from preclinical research
A modified growth hormone-releasing hormone that boosts your body's natural GH pulses for better recovery, deeper sleep, and improved body composition.
At a Glance
Quick
comparison
Dose Range
SM-130686
5–20 mg
CJC-1295 (No DAC)
100–300 mcg
Frequency
SM-130686
Multiple times daily
CJC-1295 (No DAC)
Once daily
Administration
SM-130686
Oral capsule or powder
CJC-1295 (No DAC)
Subcutaneous injection
Cycle Length
SM-130686
8-12 weeks
CJC-1295 (No DAC)
8-12 weeks
Onset Speed
SM-130686
Moderate (1-2 weeks)
CJC-1295 (No DAC)
Moderate (1-2 weeks)
Evidence Level
SM-130686
Moderate human trials (Phase 1-2)
CJC-1295 (No DAC)
Moderate human trials (Phase 1-2)
Efficacy
Benefit
ratings
Muscle and Strength
Recovery and Performance
Metabolic Health
GH Stimulation
Sleep Quality
Recovery Support
Technical Data
Compound
specifications
SM-130686
Molecular Formula
C22H24Cl2F3N3O3
Molecular Weight
506.3 g/mol (as HCl salt)
Half-Life
Not published in humans (preclinical only)
Bioavailability
28% in rats (oral administration)
CAS Number
259667-25-9
CJC-1295 (No DAC)
Molecular Formula
C152H252N44O42
Molecular Weight
3367.9 g/mol
Half-Life
30 minutes to 2 hours
Bioavailability
~100% (subcutaneous)
CAS Number
863288-34-0
Protocols
Dosing
tiers
SM-130686
CJC-1295 (No DAC)
Applications
Best
suited for
SM-130686
Lean Mass Building in Trained Athletes
SM-130686 targets GHS-R to stimulate GH release, which supports anabolic processes. Preclinical studies in rats showed significant increases in fat-free mass and body weight when combined with resistance training principles.
Age-Related GH Decline
As a GHS-R agonist, SM-130686 may help restore physiological GH secretion in adults experiencing age-related decline. The oral route is convenient for long-term administration.
Recovery and Performance
GH supports tissue repair, collagen synthesis, and recovery. May benefit individuals engaged in intensive resistance training or athletic performance work.
CJC-1295 (No DAC)
Natural Growth Hormone Optimization
Perfect for those wanting to boost their body's own GH production rather than using synthetic growth hormone. Mimics the natural pulsatile release pattern your pituitary uses.
Workout Recovery and Muscle Building
Athletes and fitness enthusiasts use it to accelerate recovery between training sessions, support lean muscle development, and reduce body fat over time.
Sleep Quality Enhancement
Because GH is naturally released during deep sleep, many users report dramatically improved sleep quality with more vivid dreams and feeling more refreshed upon waking.
Anti-Aging and Vitality
As GH levels decline with age, CJC-1295 helps restore more youthful hormone patterns, potentially improving skin quality, energy levels, and overall well-being.
Synergistic Peptide Stacking
Designed to work hand-in-hand with GHRPs like Ipamorelin. When combined, these peptides amplify each other's effects for significantly greater GH release than either alone.
Safety Profile
Side
effects
SM-130686
Common
- Appetite stimulation
- Transient water retention
Uncommon
- Joint or muscle aches
- Transient changes in blood glucose
Serious
- Potential carpal tunnel syndrome
- Unknown effects on tumor growth
CJC-1295 (No DAC)
Common
- Injection site reactions
- Flushing or warmth
- Water retention
- Increased appetite
Uncommon
- Tingling or numbness
- Headache
Serious
- Allergic reaction
Research Status
Safety
& evidence
SM-130686
Evidence Level
Moderate human trials (Phase 1-2)
FDA Status
Research compound
Safety Overview
SM-130686 is a research compound that has never been tested in humans. All safety and efficacy data come from animal studies (primarily rats). No human clinical trials have been conducted. Use carries unknown risks. Potential side effects based on GH physiology and limited preclinical work.
Contraindications
- xPregnancy or breastfeeding (no safety data)
- xActive cancer (GH stimulation may be contraindicated)
- xUncontrolled diabetes (may affect glucose metabolism)
- xSevere cardiovascular disease (GH effects on heart not fully characterized)
CJC-1295 (No DAC)
Evidence Level
Moderate human trials (Phase 1-2)
FDA Status
Research compound
Safety Overview
CJC-1295 without DAC has been studied in Phase 1-2 human clinical trials with a favorable safety profile. The most common side effects are mild and include injection site reactions and temporary flushing. Because it stimulates natural GH release rather than providing exogenous GH, it maintains the body's feedback mechanisms.
Contraindications
- xActive cancer or history of cancer
- xPregnancy or breastfeeding
- xPituitary tumors or disorders
- xHypersensitivity to GHRH analogs
- xDiabetic retinopathy
Decision Guide
Which is
right for you?
Choose SM-130686 if...
- Lean mass building (theoretical)
- Strength development (preclinical evidence)
- Body composition improvement (animal studies)
Choose CJC-1295 (No DAC) if...
- Increasing natural growth hormone levels
- Building lean muscle mass
- Improving sleep quality
- Enhancing workout recovery