Peptide Comparison
Palmitoyl Pentapeptide-4 (Matrixyl)vsPalmitoyl Oligopeptide
Collagen-boosting signal peptide clinically proven to reduce wrinkles and fine lines in photoaged skin.
Elastin-derived signal peptide that stimulates dermal matrix renewal and skin elasticity through matrikine signaling.
At a Glance
Quick
comparison
Dose Range
Palmitoyl Pentapeptide-4 (Matrixyl)
3 ppm–100 ppm mg
Palmitoyl Oligopeptide
0.003%–3% %
Frequency
Palmitoyl Pentapeptide-4 (Matrixyl)
Once daily
Palmitoyl Oligopeptide
Once daily
Administration
Palmitoyl Pentapeptide-4 (Matrixyl)
Topical
Palmitoyl Oligopeptide
Topical
Cycle Length
Palmitoyl Pentapeptide-4 (Matrixyl)
Ongoing/indefinite
Palmitoyl Oligopeptide
Ongoing/indefinite
Onset Speed
Palmitoyl Pentapeptide-4 (Matrixyl)
Moderate (1-2 weeks)
Palmitoyl Oligopeptide
Moderate (1-2 weeks)
Evidence Level
Palmitoyl Pentapeptide-4 (Matrixyl)
Limited human trials
Palmitoyl Oligopeptide
Limited human trials
Efficacy
Benefit
ratings
Anti-Wrinkle
Collagen Production
Skin Rejuvenation
Collagen Stimulation
Skin Elasticity
Skin Hydration
Technical Data
Compound
specifications
Palmitoyl Pentapeptide-4 (Matrixyl)
Molecular Formula
C39H75N7O10
Molecular Weight
802.1 Da
Half-Life
Approximately 20-30 minutes in skin (rapidly degraded by aminopeptidases; palmitoylation improves stability vs unmodified KTTKS)
Bioavailability
Topical penetration through stratum corneum to dermis; detected at 4.2 µg/cm² in SC, 2.8 µg/cm² in epidermis, 0.3 µg/cm² in dermis
CAS Number
214047-00-4
Palmitoyl Oligopeptide
Molecular Formula
C36H63N5O7 (hexapeptide-12 variant)
Molecular Weight
694.9 Da (approximate for palmitoylated hexapeptide)
Half-Life
Topical application; degradation rate dependent on formulation pH and temperature
Bioavailability
Enhanced dermal penetration via palmitate conjugation; self-assembles with endogenous skin proteins
CAS Number
171263-26-6
Applications
Best
suited for
Palmitoyl Pentapeptide-4 (Matrixyl)
Individuals seeking non-invasive anti-wrinkle treatment
Palmitoyl Pentapeptide-4 (Matrixyl) is particularly well-suited for individuals focused on individuals seeking non-invasive anti-wrinkle treatment. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Those with photoaged skin showing fine lines and loss of firmness
Palmitoyl Pentapeptide-4 (Matrixyl) is particularly well-suited for individuals focused on those with photoaged skin showing fine lines and loss of firmness. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
People looking to boost collagen production through topical skincare
Palmitoyl Pentapeptide-4 (Matrixyl) is particularly well-suited for individuals focused on people looking to boost collagen production through topical skincare. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Sensitive skin types seeking well-tolerated anti-aging actives
Palmitoyl Pentapeptide-4 (Matrixyl) is particularly well-suited for individuals focused on sensitive skin types seeking well-tolerated anti-aging actives. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Palmitoyl Oligopeptide
Individuals seeking collagen and elastin stimulation through topical peptides
Palmitoyl Oligopeptide is particularly well-suited for individuals focused on individuals seeking collagen and elastin stimulation through topical peptides. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Those with age-related loss of skin firmness and elasticity
Palmitoyl Oligopeptide is particularly well-suited for individuals focused on those with age-related loss of skin firmness and elasticity. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
People looking for gentle anti-aging actives suitable for sensitive skin
Palmitoyl Oligopeptide is particularly well-suited for individuals focused on people looking for gentle anti-aging actives suitable for sensitive skin. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Users wanting to complement retinoid or vitamin C regimens with peptide support
Palmitoyl Oligopeptide is particularly well-suited for individuals focused on users wanting to complement retinoid or vitamin c regimens with peptide support. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Safety Profile
Side
effects
Palmitoyl Pentapeptide-4 (Matrixyl)
Common
- Mild Tingling
- Transient Redness
- Dryness with Exfoliants
- Mild Irritation
Uncommon
- Contact Dermatitis
Serious
- Excessive Collagen Synthesis and Scar Risk
Palmitoyl Oligopeptide
Common
- Transient Dryness
- Mild Tingling
- Product Interaction Sensitivity
- Minimal Erythema
Uncommon
- Contact Dermatitis
Serious
- Allergic Reaction
- Comedogenic Potential from Palmitic Acid
Research Status
Safety
& evidence
Palmitoyl Pentapeptide-4 (Matrixyl)
Evidence Level
Limited human trials
FDA Status
Research compound
Safety Overview
Palmitoyl pentapeptide-4 (Matrixyl) demonstrates excellent dermatological safety with GRAS/safe-for-cosmetic status; extensively used in anti-aging skincare for 20+ years with no serious adverse events. Skin irritation potential is minimal at recommended 2-3% concentrations (irritation index <0.5). No systemic absorption via intact skin; confined to epidermis/dermis per Franz diffusion cell studies. Stability in formulations verified through HPLC analysis.
Contraindications
- xKnown hypersensitivity to palmitoyl pentapeptide-4 or formulation excipients
- xActive skin infections at the application site
- xSeverely compromised skin barrier with open wounds
- xNo known systemic contraindications at cosmetic concentrations
Palmitoyl Oligopeptide
Evidence Level
Limited human trials
FDA Status
Research compound
Safety Overview
Palmitoyl oligopeptide has GRAS-equivalent status for cosmetic use with no serious adverse events in safety testing up to 5% w/w in topical formulations. Mild skin irritation reported in <3% of subjects at high concentrations (irritation index 0-1 on 0-10 scale). No dermal penetration beyond stratum corneum in Franz diffusion cell studies. Long-term use data spans 15+ years of cosmetic industry application with no systemic toxicity.
Contraindications
- xKnown allergy or hypersensitivity to palmitoylated peptides or formulation excipients
- xActive skin infections or open wounds at the application site
- xConcurrent use with strong oxidizing agents that may degrade peptide structure
- xSevere dermatitis or eczema flares at intended application areas
Decision Guide
Which is
right for you?
Choose Palmitoyl Pentapeptide-4 (Matrixyl) if...
- Individuals seeking non-invasive anti-wrinkle treatment
- Those with photoaged skin showing fine lines and loss of firmness
- People looking to boost collagen production through topical skincare
- Sensitive skin types seeking well-tolerated anti-aging actives
Choose Palmitoyl Oligopeptide if...
- Individuals seeking collagen and elastin stimulation through topical peptides
- Those with age-related loss of skin firmness and elasticity
- People looking for gentle anti-aging actives suitable for sensitive skin
- Users wanting to complement retinoid or vitamin C regimens with peptide support