Peptide Comparison
Myristoyl Pentapeptide-17vsAcetyl Hexapeptide-3 (Argireline)
Keratin-stimulating lipopeptide specifically designed to enhance eyelash and eyebrow growth through hair follicle activation.
SNARE complex inhibitor that reduces expression wrinkles through topical neuromuscular modulation — the 'Botox in a bottle' peptide.
At a Glance
Quick
comparison
Dose Range
Myristoyl Pentapeptide-17
0.01%–0.15% %
Acetyl Hexapeptide-3 (Argireline)
5%–10% %
Frequency
Myristoyl Pentapeptide-17
Once daily
Acetyl Hexapeptide-3 (Argireline)
Once daily
Administration
Myristoyl Pentapeptide-17
Topical
Acetyl Hexapeptide-3 (Argireline)
Topical
Cycle Length
Myristoyl Pentapeptide-17
Ongoing/indefinite
Acetyl Hexapeptide-3 (Argireline)
Ongoing/indefinite
Onset Speed
Myristoyl Pentapeptide-17
Moderate (1-2 weeks)
Acetyl Hexapeptide-3 (Argireline)
Moderate (1-2 weeks)
Evidence Level
Myristoyl Pentapeptide-17
Limited human trials
Acetyl Hexapeptide-3 (Argireline)
Limited human trials
Efficacy
Benefit
ratings
Eyelash Growth
Hair Strengthening
Safety Profile
Expression Wrinkle Reduction
Non-Invasive Treatment
Technical Data
Compound
specifications
Myristoyl Pentapeptide-17
Molecular Formula
C41H81N9O6
Molecular Weight
796.2 Da
Half-Life
Topical application; sustained follicular activity with daily reapplication
Bioavailability
Enhanced follicular penetration via myristic acid (C14) lipid conjugation
CAS Number
959610-30-1
Acetyl Hexapeptide-3 (Argireline)
Molecular Formula
C35H62N14O11S
Molecular Weight
887.0 Da
Half-Life
Topical stability dependent on formulation; methionine residue susceptible to oxidation; stable at pH 5.5-7.7
Bioavailability
Limited skin penetration (0.22-0.54%); primarily acts at stratum corneum and superficial epidermis; O/W emulsions enhance delivery
CAS Number
616204-22-9
Applications
Best
suited for
Myristoyl Pentapeptide-17
Individuals seeking longer, fuller eyelashes without prostaglandin-based prescriptions
Myristoyl Pentapeptide-17 is particularly well-suited for individuals focused on individuals seeking longer, fuller eyelashes without prostaglandin-based prescriptions. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Those with naturally thin or sparse eyebrows wanting natural enhancement
Myristoyl Pentapeptide-17 is particularly well-suited for individuals focused on those with naturally thin or sparse eyebrows wanting natural enhancement. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
People recovering from lash or brow loss due to extensions, aging, or over-plucking
Myristoyl Pentapeptide-17 is particularly well-suited for individuals focused on people recovering from lash or brow loss due to extensions, aging, or over-plucking. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Users wanting a gentle peptide-based alternative to bimatoprost (Latisse)
Myristoyl Pentapeptide-17 is particularly well-suited for individuals focused on users wanting a gentle peptide-based alternative to bimatoprost (latisse). Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Acetyl Hexapeptide-3 (Argireline)
Individuals seeking non-invasive reduction of expression lines and dynamic wrinkles
Acetyl Hexapeptide-3 (Argireline) is particularly well-suited for individuals focused on individuals seeking non-invasive reduction of expression lines and dynamic wrinkles. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Those with needle phobia who want botulinum toxin-like effects without injections
Acetyl Hexapeptide-3 (Argireline) is particularly well-suited for individuals focused on those with needle phobia who want botulinum toxin-like effects without injections. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
People targeting crow's feet, forehead lines, and glabellar creases
Acetyl Hexapeptide-3 (Argireline) is particularly well-suited for individuals focused on people targeting crow's feet, forehead lines, and glabellar creases. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Individuals looking for preventive anti-wrinkle treatment to slow expression line formation
Acetyl Hexapeptide-3 (Argireline) is particularly well-suited for individuals focused on individuals looking for preventive anti-wrinkle treatment to slow expression line formation. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Safety Profile
Side
effects
Myristoyl Pentapeptide-17
Common
- Mild Tingling at Lash Line
- Temporary Eyelid Dryness
- Product Residue Buildup
- Lash Shedding During Initial Phase
Uncommon
- Periorbital Sensitivity
Serious
- Allergic Contact Reaction
- Lipid Peroxidation and Oxidative Stress
Acetyl Hexapeptide-3 (Argireline)
Common
- Mild Skin Irritation
- Transient Redness
- Slight Dryness
- Stinging on Compromised Skin
Uncommon
- Contact Dermatitis
Serious
- Allergic Contact Dermatitis
Research Status
Safety
& evidence
Myristoyl Pentapeptide-17
Evidence Level
Limited human trials
FDA Status
Research compound
Safety Overview
Myristoyl pentapeptide-17 demonstrates excellent cosmetic safety with GRAS/safe-for-use status in topical formulations up to 3% concentration. No serious adverse events in 10+ years of cosmetic industry application; mild skin irritation rare (<1%) at recommended concentrations. Dermal penetration limited to epidermis; no systemic absorption in vitro. Well-tolerated in combination with other anti-aging ingredients; photostability adequate for cosmetic formulations.
Contraindications
- xKnown hypersensitivity to myristoylated peptides or formulation components
- xActive eye infections, styes, or periorbital dermatitis
- xPost-surgical eye conditions where topical application is contraindicated
- xConcurrent use of prescription eyelash growth products without medical guidance
Acetyl Hexapeptide-3 (Argireline)
Evidence Level
Limited human trials
FDA Status
Research compound
Safety Overview
Acetyl Hexapeptide-3 demonstrates an excellent safety profile for topical cosmetic use with no serious adverse events reported in clinical studies. At the 10% concentrations used in cosmetic formulations, systemic absorption is minimal and no neurotoxicity has been observed despite its mechanism of action on the neuromuscular junction. The peptide shows a safety margin of approximately 100-fold compared to toxic reference compounds. Primary concerns are limited to local skin irritation in sensitive individuals, such as mild erythema, transient stinging, or contact dermatitis in those with peptide hypersensitivity.
Contraindications
- xKnown hypersensitivity to acetyl hexapeptide-3 or formulation components
- xActive skin infections or open wounds at the application site
- xNo known systemic contraindications at cosmetic concentrations
- xUse with caution in individuals with neuromuscular disorders (theoretical concern)
Decision Guide
Which is
right for you?
Choose Myristoyl Pentapeptide-17 if...
- Individuals seeking longer, fuller eyelashes without prostaglandin-based prescriptions
- Those with naturally thin or sparse eyebrows wanting natural enhancement
- People recovering from lash or brow loss due to extensions, aging, or over-plucking
- Users wanting a gentle peptide-based alternative to bimatoprost (Latisse)
Choose Acetyl Hexapeptide-3 (Argireline) if...
- Individuals seeking non-invasive reduction of expression lines and dynamic wrinkles
- Those with needle phobia who want botulinum toxin-like effects without injections
- People targeting crow's feet, forehead lines, and glabellar creases
- Individuals looking for preventive anti-wrinkle treatment to slow expression line formation