Peptide Comparison
GHRH (1-29)vsCJC-1295 with DAC
The shortest synthetic growth hormone-releasing peptide that tells your body to build taller and stronger.
Long-acting growth hormone releaser that works around the clock to boost your body's natural GH production with just one or two injections per week.
At a Glance
Quick
comparison
Dose Range
GHRH (1-29)
100–300 mcg
CJC-1295 with DAC
1000–2000 mcg
Frequency
GHRH (1-29)
Once daily
CJC-1295 with DAC
Twice weekly
Administration
GHRH (1-29)
Subcutaneous injection
CJC-1295 with DAC
Subcutaneous injection
Cycle Length
GHRH (1-29)
8-12 weeks
CJC-1295 with DAC
8-12 weeks
Onset Speed
GHRH (1-29)
Moderate (1-2 weeks)
CJC-1295 with DAC
Moderate (1-2 weeks)
Evidence Level
GHRH (1-29)
Strong human trials (Phase 3 or FDA approved)
CJC-1295 with DAC
Moderate human trials (Phase 1-2)
Efficacy
Benefit
ratings
Growth and Development
Body Composition
Performance and Recovery
GH Elevation
Convenience
Recovery Support
Technical Data
Compound
specifications
GHRH (1-29)
Molecular Formula
C149H246N44O42S
Molecular Weight
3357.9 g/mol
Half-Life
~10-20 minutes
Bioavailability
Subcutaneous: moderate; Intranasal: 3-5%
CAS Number
86168-78-7
CJC-1295 with DAC
Molecular Formula
C165H269N47O46
Molecular Weight
3647.28 g/mol
Half-Life
6-8 days
Bioavailability
~100% (subcutaneous)
CAS Number
863288-34-0
Protocols
Dosing
tiers
GHRH (1-29)
CJC-1295 with DAC
Applications
Best
suited for
GHRH (1-29)
Helping Kids Catch Up in Height
Children diagnosed with growth hormone deficiency struggle to reach normal heights. GHRH (1-29) works by sending a signal to the pituitary gland that says 'make more growth hormone.' Studies show children getting daily 30 mcg/kg doses at bedtime experienced sustained improvements in height velocity over 12+ months. It's gentle and lets the body do the work naturally.
Testing for Growth Problems
Doctors need a safe, accurate way to figure out if someone has a growth hormone deficiency. Giving a small dose of GHRH (1-29) and measuring the growth hormone response is fast and specific. It's like asking your pituitary gland 'can you produce growth hormone?' and listening to the answer.
Natural Optimization for Adults
Some adults have lower-than-optimal growth hormone levels as they age. GHRH (1-29) stimulates the body's own hormone factories rather than replacing hormones artificially. This approach keeps your body's natural feedback loops working properly.
CJC-1295 with DAC
Growth Hormone Optimization
CJC-1295 with DAC excels at providing a sustained, steady elevation of growth hormone levels. Unlike shorter-acting peptides that create brief spikes, the DAC modification keeps GH elevated for days, mimicking a more youthful hormone profile.
Muscle Building and Recovery
By increasing both GH and IGF-1 levels, this peptide supports protein synthesis and muscle repair. Users often notice improved recovery between workouts and better ability to build and maintain lean muscle mass.
Anti-Aging and Longevity
Growth hormone naturally declines with age, contributing to many signs of aging. CJC-1295 with DAC helps restore more youthful GH levels, potentially supporting better skin quality, energy levels, and overall vitality.
Body Composition Improvement
The combination of increased GH and IGF-1 promotes fat metabolism while preserving muscle tissue. Many users experience gradual fat loss, particularly in stubborn areas, while maintaining or building lean mass.
Convenient Weekly Dosing
Unlike peptides requiring daily or twice-daily injections, the extended half-life of CJC-1295 with DAC means just one or two injections per week provide continuous benefits. Ideal for those who want results without daily protocols.
Safety Profile
Side
effects
GHRH (1-29)
Common
- Facial flushing
- Injection site discomfort
- Mild dizziness
Uncommon
- Nausea
- Headache
- Local allergic reaction
Serious
- Cardiovascular complications
CJC-1295 with DAC
Common
- Injection site reactions
- Water retention
- Flushing
- Tingling sensation
Uncommon
- Headaches
- Fatigue or lethargy
- Joint discomfort
Serious
- Carpal tunnel symptoms
- Blood glucose elevation
Research Status
Safety
& evidence
GHRH (1-29)
Evidence Level
Strong human trials (Phase 3 or FDA approved)
FDA Status
FDA approved for this use
Safety Overview
GHRH (1-29) has been studied extensively in both children and adults. It works by mimicking a natural hormone your body already produces, making it relatively gentle. Side effects are typically mild and temporary, mainly limited to facial flushing and minor injection site reactions. Long-term studies show it's well-tolerated when used as directed.
Contraindications
- xActive malignancy or recent cancer diagnosis
- xAcute critical illness or severe infection
- xKnown hypersensitivity to sermorelin or any component
CJC-1295 with DAC
Evidence Level
Moderate human trials (Phase 1-2)
FDA Status
Research compound
Safety Overview
CJC-1295 with DAC was evaluated in Phase 1-2 human clinical trials where it demonstrated a generally favorable safety profile. The most common adverse events were mild injection site reactions including temporary pain, swelling, and redness. No serious adverse events were reported in the published clinical studies. The compound was being developed for HIV-associated lipodystrophy before the program was discontinued.
Contraindications
- xActive cancer or history of malignancy
- xPregnancy or breastfeeding
- xPituitary tumors or disorders
- xDiabetic retinopathy
- xUncontrolled diabetes
Decision Guide
Which is
right for you?
Choose GHRH (1-29) if...
- Children with growth hormone deficiency who need to catch up in height
- Adults seeking to optimize natural growth hormone levels
- People being tested for growth hormone deficiency
Choose CJC-1295 with DAC if...
- Boosting natural growth hormone production
- Building lean muscle mass
- Improving body composition
- Anti-aging and longevity