Peptide Comparison
EnalaprilvsAngiotensin (1-7)
The blood pressure champion that helped millions breathe easier and live longer
The heart-friendly peptide that balances your blood pressure and protects your cardiovascular system
At a Glance
Quick
comparison
Dose Range
Enalapril
2.5 mg–40 mg mg
Angiotensin (1-7)
0.5-1 mcg/kg–5-10 mcg/kg mcg
Frequency
Enalapril
Once daily
Angiotensin (1-7)
Once daily
Administration
Enalapril
Oral tablet
Angiotensin (1-7)
As directed by healthcare provider
Cycle Length
Enalapril
Ongoing/indefinite
Angiotensin (1-7)
Ongoing/indefinite
Onset Speed
Enalapril
Moderate (1-2 weeks)
Angiotensin (1-7)
Moderate (1-2 weeks)
Evidence Level
Enalapril
Strong human trials (Phase 3 or FDA approved)
Angiotensin (1-7)
Moderate human trials (Phase 1-2)
Efficacy
Benefit
ratings
Cardiovascular Health
Long-term Protection
Quality of Life
Heart Health & Protection
Blood Pressure Balance
Anti-Inflammatory Support
Technical Data
Compound
specifications
Enalapril
Molecular Formula
C20H28N2O5
Molecular Weight
376.4 g/mol
Half-Life
Enalapril: 1 hour; Enalaprilat (active form): 11 hours effective half-life
Bioavailability
Approximately 60% oral bioavailability when taken by mouth
CAS Number
75847-73-3
Angiotensin (1-7)
Molecular Formula
C41H62N12O11
Molecular Weight
899.02 g/mol
Half-Life
Approximately 2-6 hours (varies by route of administration)
Bioavailability
Varies by route of administration
CAS Number
25016-41-7
Applications
Best
suited for
Enalapril
Managing hypertension to prevent serious complications
Enalapril is particularly well-suited for individuals focused on managing hypertension to prevent serious complications. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Treating heart failure and improving survival rates
Enalapril is particularly well-suited for individuals focused on treating heart failure and improving survival rates. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Protecting organs from damage caused by high blood pressure
Enalapril is particularly well-suited for individuals focused on protecting organs from damage caused by high blood pressure. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Angiotensin (1-7)
Cardiovascular health and heart protection
Angiotensin (1-7) is particularly well-suited for individuals focused on cardiovascular health and heart protection. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Blood pressure management and hypertension
Angiotensin (1-7) is particularly well-suited for individuals focused on blood pressure management and hypertension. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Recovery from heart-related conditions
Angiotensin (1-7) is particularly well-suited for individuals focused on recovery from heart-related conditions. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Anti-inflammatory support
Angiotensin (1-7) is particularly well-suited for individuals focused on anti-inflammatory support. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Safety Profile
Side
effects
Enalapril
Common
- Dry cough
- Dizziness
- Fatigue
- Hyperkalemia
- Angioedema
Serious
- Severe allergic reaction
Angiotensin (1-7)
Common
- Hypotension (Low Blood Pressure)
- Dizziness or Lightheadedness
- Injection Site Reactions
- Headache
Serious
- Hyperkalemia (High Potassium)
Research Status
Safety
& evidence
Enalapril
Evidence Level
Strong human trials (Phase 3 or FDA approved)
FDA Status
FDA approved for this use
Safety Overview
Enalapril is an FDA-approved ACE inhibitor with safety data spanning over 40 years of clinical use and post-market surveillance in millions of hypertensive patients. Persistent dry cough occurs in 10-20% of patients, caused by kinase II inhibition and bradykinin accumulation. Hyperkalemia is a serious risk, particularly in renal impairment, diabetes, or concurrent NSAID/potassium-sparing diuretic use—potassium monitoring is essential. Angioedema (0.1-0.2%) is a rare but life-threatening emergency, absolute contraindication for future ACE inhibitor use. Hypotension can occur in volume-depleted patients or those on concurrent vasodilators. Acute kidney injury risk exists in patients with bilateral renal artery stenosis or single kidney. Fetal teratogenicity is well-documented in pregnancy.
Contraindications
- xPregnancy (causes serious fetal harm)
- xHistory of angioedema with ACE inhibitors
- xSevere renal dysfunction
- xConcurrent use with certain other blood pressure medications
- xPotassium supplementation without medical supervision
Angiotensin (1-7)
Evidence Level
Moderate human trials (Phase 1-2)
FDA Status
Research compound
Safety Overview
Angiotensin (1-7) is not FDA-approved and has no completed human clinical trials, with all safety data limited to animal studies and in vitro mechanistic work. Animal studies suggest potential benefits in hypertension and cardiac remodeling but also reveal risks of hypotension, particularly with concurrent ACE inhibitor or ARB therapy. The peptide's effects on systemic inflammation and immune function in animal models are not validated in humans. No pharmacokinetic data exists defining safe doses, optimal delivery routes, or organ accumulation patterns in humans.
Contraindications
- xSevere hypotension or uncontrolled low blood pressure
- xAcute myocardial infarction in early stages
- xConcurrent use with certain ACE inhibitors without medical supervision
- xPregnancy and breastfeeding (insufficient safety data)
Decision Guide
Which is
right for you?
Choose Enalapril if...
- Managing hypertension to prevent serious complications
- Treating heart failure and improving survival rates
- Protecting organs from damage caused by high blood pressure
Choose Angiotensin (1-7) if...
- Cardiovascular health and heart protection
- Blood pressure management and hypertension
- Recovery from heart-related conditions
- Anti-inflammatory support