Sexual Health Protocol
PT-141 (Bremelanotide)Complete Dosing & Administration Guide
The first FDA-approved peptide that works through your brain to reignite sexual desire—think of it as flipping the 'on' switch for arousal rather than just boosting blood flow like traditional ED meds.
Dose Range
1.75-2mg
Frequency
As needed
Route
Subcutaneous injection
Cycle Length
Ongoing/indefinite
Dosing
How much
do I take?
Starting Dose
1 mg
Starting low helps you gauge your response to nausea, which is the most common side effect. If you tolerate 1mg well, you can increase to the standard dose. Never take more than one dose in 24 hours.
Standard Dose
1.75 mg
This is the FDA-approved dose for treating HSDD in women. Clinical trials showed this dose provides the best balance of effectiveness and tolerability. Don't exceed 8 doses per month.
Advanced Dose
2 mg
Some research protocols and clinicians use up to 2mg, though 1.75mg is the FDA-approved dose. Higher doses increase the risk of nausea without necessarily improving effectiveness. Stay within the 8 doses per month limit.
Timing
Best time to take
Take PT-141 at least 45 minutes before anticipated sexual activity. Effects typically begin within 45-60 minutes and can last several hours. Some people find it works better with 60-90 minutes lead time.
With food?
Taking PT-141 on an empty stomach may increase nausea. A light meal or snack beforehand can help reduce stomach upset without significantly affecting absorption.
If stacking
PT-141 is typically used as a standalone treatment. Its unique mechanism of action through melanocortin receptors means it doesn't directly interact with most other peptides, but consult your healthcare provider before combining with other treatments.
Adjusting Your Dose
Increase if
- +You tolerate the starting dose with minimal nausea
- +Effects feel insufficient after multiple tries at current dose
- +Your healthcare provider recommends adjustment based on your response
Decrease if
- -Nausea is severe or interferes with the experience
- -You experience significant blood pressure increases
- -Flushing or headaches are uncomfortable
- -Side effects outweigh the benefits
Signs of right dose
- ✓Noticeable increase in sexual desire within 1-2 hours
- ✓Manageable or no nausea
- ✓Enhanced arousal response during intimacy
- ✓No significant blood pressure changes
Dosing Calculator
Calculate Your Exact Dose
Step 1: Peptide Weight
Find the weight printed on your peptide vial label
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The peptide weight is printed on the label
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The weight is on the label
Administration
How do I
use it?
Reconstitution
What you need
- •Bacteriostatic water (BAC water)—contains preservative for multi-dose use
- •Insulin syringes (29-31 gauge) for injection
- •Alcohol swabs for cleaning vial tops and injection sites
- •Your PT-141 powder vial
Injection
Route
Subcutaneous injection (just under the skin)—this is how the FDA-approved Vyleesi autoinjector delivers the dose
Best sites
- •Abdomen (about 2 inches away from belly button)—FDA recommended site
- •Front or outer thigh (middle section)
- •Back of upper arm (if someone can help)
Technique
- 1.Wash your hands thoroughly with soap and water
- 2.Clean the injection site with an alcohol swab and let it dry completely
- 3.If using a syringe: pinch about an inch of skin to create a fold
- 4.Insert the needle at a 45-90 degree angle (45 if lean, 90 if more tissue)
- 5.Inject slowly and steadily over a few seconds
- 6.Wait 5 seconds before withdrawing the needle
- 7.Apply light pressure with a clean cotton ball if needed—don't rub
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
PT-141 has undergone rigorous FDA review and was approved in 2019 based on two large Phase 3 clinical trials involving over 1,200 women. The most common side effect is nausea (affecting about 40% of users), which typically decreases with repeated use. The drug causes transient increases in blood pressure (average 2-3 mmHg) and slight decreases in heart rate, which is why it's contraindicated in uncontrolled hypertension. Long-term safety data from the 52-week extension study showed no new safety concerns.
PT-141 (as Vyleesi) has strong safety data from FDA-required Phase 3 trials and ongoing post-marketing surveillance. It's one of the most thoroughly studied peptides for sexual health. The clinical trials were conducted by Palatin Technologies and AMAG Pharmaceuticals with FDA oversight.
Common Side Effects
Experienced by some users
Nausea
The most common side effect, affecting about 40% of users in clinical trials. It typically occurs within the first hour and resolves on its own.
Management: Eat a light snack before your dose. Start with a lower dose (1mg) to test tolerance. Anti-nausea medications like ginger or ondansetron may help. Nausea often decreases with repeated use.
Facial flushing
About 20% of users experience warmth and redness in the face. This is related to the melanocortin receptors affecting blood vessels.
Management: This is usually mild and temporary. Stay hydrated and avoid alcohol, which can worsen flushing. It typically subsides within 1-2 hours.
Headache
Reported by about 12% of users, headaches are usually mild and similar to a tension headache.
Management: Stay well-hydrated. Over-the-counter pain relievers like acetaminophen can help if needed. Headaches typically resolve within a few hours.
Injection site reactions
Redness, itching, or minor bruising at the injection site is common with any subcutaneous injection.
Management: Rotate injection sites between abdomen and thighs. Ensure proper technique with clean, appropriate-gauge needles. A cool compress can help.
Less Common
- •Skin darkening (hyperpigmentation)
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Severe nausea that makes the experience unpleasant or affects your health
- ×Significant blood pressure increases, especially if you feel chest discomfort or severe headache
- ×Noticeable skin darkening that concerns you (may be irreversible)
- ×Any signs of allergic reaction—hives, swelling, difficulty breathing
- ×The medication isn't providing the desired effect after multiple attempts
- ×You become pregnant or are trying to conceive
PT-141 (Vyleesi) is an FDA-approved medication, but it should be used under healthcare provider supervision. This information is educational—always consult your doctor about starting, stopping, or adjusting any medication. Report any unexpected side effects to your healthcare provider.
Interactions
With other peptides
- !Both act on melanocortin receptors. Combining them increases risk of side effects including nausea, blood pressure changes, and hyperpigmentation. Avoid using together.
- ✓May complement PT-141 by enhancing emotional bonding aspects of intimacy. Generally considered safe to combine, but research is limited.
- ✓No known direct interactions. BPC-157 works on different pathways (healing and gut health). Can likely be used in the same overall protocol.
With medications
- !Blood pressure medications - PT-141 affects blood pressure. Combining with antihypertensives may have unpredictable effects. Use only under medical supervision with monitoring.
- !Naltrexone - Naltrexone blocks opioid receptors and may reduce PT-141's effectiveness through overlapping neural pathways. Effectiveness may be diminished.
- !PDE5 inhibitors (Viagra, Cialis) - Both affect cardiovascular parameters. While sometimes combined in research for ED, this should only be done under medical supervision due to additive effects.
- !MAO inhibitors - PT-141 affects dopamine and norepinephrine release. MAOIs can dangerously amplify these effects. Avoid combining.
With supplements
- ✓Ginger - Can help manage PT-141's nausea side effect. Safe and potentially helpful to take before your dose.
- ✓Caffeine - Both can affect blood pressure and heart rate. Moderate caffeine is probably fine, but avoid large amounts close to your PT-141 dose.
- ✓Alcohol - Can worsen flushing and nausea, and may affect sexual response. Best to minimize alcohol when using PT-141.
- ✓L-arginine - Both affect blood flow mechanisms. No known dangerous interactions, but effects may add up. Monitor how you feel.
Want the Full Picture?
View the complete PT-141 (Bremelanotide) research profile including mechanism of action, clinical studies, effectiveness timeline, and FAQ.
View Full PT-141 (Bremelanotide) Profile