Peptide Comparison
ThymopoietinvsThymopentin (TP-5)
Thymic hormone that supports T-cell development and immune function, with the active fragment thymopentin (TP-5) used in clinical research
Immune-boosting pentapeptide fragment that enhances T-cell function and dendritic cell maturation
At a Glance
Quick
comparison
Dose Range
Thymopoietin
50–100 mg
Thymopentin (TP-5)
1–2 mg
Frequency
Thymopoietin
Every other day
Thymopentin (TP-5)
Once daily
Administration
Thymopoietin
Subcutaneous injection
Thymopentin (TP-5)
Subcutaneous injection
Cycle Length
Thymopoietin
4-6 weeks
Thymopentin (TP-5)
4-6 weeks
Onset Speed
Thymopoietin
Moderate (1-2 weeks)
Thymopentin (TP-5)
Moderate (1-2 weeks)
Evidence Level
Thymopoietin
Limited human trials
Thymopentin (TP-5)
Moderate human trials (Phase 1-2)
Efficacy
Benefit
ratings
Immune Cell Development
Post-Surgical Recovery
Cancer Immunotherapy Enhancement
Immune Enhancement
Cardiovascular Support
Post-Recovery Support
Technical Data
Compound
specifications
Thymopoietin
Molecular Formula
C246H404N66O73
Molecular Weight
5454
Half-Life
Minutes to hours in plasma
Bioavailability
Moderate with subcutaneous injection
CAS Number
67632-30-6
Thymopentin (TP-5)
Molecular Formula
C30H49N9O9
Molecular Weight
679.8
Half-Life
30 seconds to few minutes in plasma
Bioavailability
Sustained release via subcutaneous route
CAS Number
69558-55-0
Applications
Best
suited for
Thymopoietin
Cancer Treatment Support
Used alongside chemotherapy to maintain immune function and reduce treatment side effects while enhancing anti-tumor immunity
Post-Surgical Immune Recovery
Helps restore T-cell function and prevent immune depression following major surgery or serious medical stress
HIV-Related Immune Support
Combined with antiretroviral therapy to support T-cell populations and improve immune response
Thymopentin (TP-5)
Immune System Enhancement
Thymopentin directly increases T-cell function and promotes dendritic cell maturation, making it ideal for people seeking to boost immune response naturally
Cardiac Health Support
Clinical trials show thymopentin improves ejection fraction and exercise capacity in elderly heart failure patients while enhancing immune markers
Post-Surgery Recovery
Helps restore immune function after major surgery and protects important immune responses during recovery period
Safety Profile
Side
effects
Thymopoietin
Common
- Injection site redness or swelling
- Mild fever
- Transient lymphocytosis
Uncommon
- Mild to moderate fatigue
- Temporary headaches
- Joint or muscle aches
Serious
- Neuromuscular weakness or myasthenia-like symptoms
- Severe allergic reaction (anaphylaxis)
- Autoimmune flare
Thymopentin (TP-5)
Common
- Local injection site reaction
- Mild fatigue
- Transient fever
Uncommon
- Muscle aches
- Mild headache
Serious
- Allergic reaction
Research Status
Safety
& evidence
Thymopoietin
Evidence Level
Limited human trials
FDA Status
Research compound
Safety Overview
Thymopoietin is a naturally-derived thymic hormone with a well-characterized mechanism but limited human safety data. Most clinical experience comes from thymopentin (TP-5), the active pentapeptide fragment. It is generally well-tolerated but has important safety considerations, particularly regarding neuromuscular effects.
Contraindications
- xMyasthenia gravis or other neuromuscular junction disorders
- xActive autoimmune diseases
- xPregnancy and breastfeeding
- xSevere allergic reactions to thymic proteins
Thymopentin (TP-5)
Evidence Level
Moderate human trials (Phase 1-2)
FDA Status
Research compound
Safety Overview
Thymopentin is well-tolerated with minimal side effects reported in clinical trials. Most adverse events are mild and local. No serious safety concerns have emerged from decades of clinical use in China and Europe.
Contraindications
- xPregnancy and breastfeeding
- xActive malignancy (without medical supervision)
- xSevere immunosuppression
- xHypersensitivity to peptide medications
Decision Guide
Which is
right for you?
Choose Thymopoietin if...
- Supporting immune function during cancer treatment
- Recovering immune function after surgery
- Managing HIV-related immune deficiencies
- Enhancing response to other immunotherapies
Choose Thymopentin (TP-5) if...
- Immune system strengthening
- Recovering from illness or surgery
- Managing autoimmune conditions
- Supporting cardiac health in elderly patients