Peptide Comparison
AdrenomedullinvsBPC-157
A powerful vasodilatory peptide that relaxes blood vessels and helps your body maintain healthy fluid balance and blood pressure.
The "Wolverine peptide" known for its remarkable healing properties across tendons, ligaments, muscles, and the gut.
At a Glance
Quick
comparison
Dose Range
Adrenomedullin
As prescribed–As prescribed mg
BPC-157
250–500 mcg
Frequency
Adrenomedullin
Once daily
BPC-157
Once daily
Administration
Adrenomedullin
Intravenous infusion
BPC-157
Subcutaneous injection
Cycle Length
Adrenomedullin
Ongoing/indefinite
BPC-157
4-6 weeks
Onset Speed
Adrenomedullin
Moderate (1-2 weeks)
BPC-157
Moderate (1-2 weeks)
Evidence Level
Adrenomedullin
Moderate human trials (Phase 1-2)
BPC-157
Strong preclinical (extensive animal studies)
Efficacy
Benefit
ratings
Cardiovascular Support
Tissue Protection
Immune Function
Primary Benefit
Secondary Benefit
Additional Benefit
Technical Data
Compound
specifications
Adrenomedullin
Molecular Formula
C264H406N80O77S3
Molecular Weight
6029 Da (Daltons)
Half-Life
Approximately 20-30 minutes in plasma (rapid metabolism)
Bioavailability
Parenteral administration only; peptide undergoes proteolytic cleavage in circulation
CAS Number
148498-78-6
BPC-157
Molecular Formula
C62H98N16O22
Molecular Weight
1419.53 g/mol
Half-Life
4-6 hours
Bioavailability
~100% (subcutaneous)
CAS Number
137525-51-0
Protocols
Dosing
tiers
Adrenomedullin
BPC-157
Applications
Best
suited for
Adrenomedullin
Cardiovascular health optimization
Adrenomedullin is particularly well-suited for individuals focused on cardiovascular health optimization. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Maintaining healthy blood pressure
Adrenomedullin is particularly well-suited for individuals focused on maintaining healthy blood pressure. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Recovery from illness or sepsis
Adrenomedullin is particularly well-suited for individuals focused on recovery from illness or sepsis. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Tissue protection and oxygen delivery
Adrenomedullin is particularly well-suited for individuals focused on tissue protection and oxygen delivery. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
BPC-157
Tendon and ligament injuries
Sprains, strains, tears, tendinitis - BPC-157 accelerates collagen synthesis and tissue repair
Gut healing
IBS, leaky gut, ulcers, inflammatory bowel conditions - derived from gastric juice, it has a natural affinity for digestive tissue
Muscle injuries
Strains, post-workout recovery, chronic muscle issues - promotes angiogenesis and growth factor expression
Joint problems
Arthritis support, joint pain, cartilage issues - anti-inflammatory and regenerative properties
Post-surgical recovery
Accelerating healing after procedures - works systemically to enhance the body's repair mechanisms
Safety Profile
Side
effects
Adrenomedullin
Common
- Mild discomfort at treatment site
- Excessive blood pressure lowering (hypotension)
- Headaches (from pressure changes)
- Flushing and mild facial redness
- Dizziness or lightheadedness
- Mild electrolyte shifts
- Localized injection site reactions
- Increased urination (natriuretic effect)
Serious
- Severe allergic reaction
BPC-157
Common
- Injection site redness
- Mild nausea
- Dizziness
Uncommon
- Headache
- Fatigue
- Hot/cold sensations
Serious
- Allergic reaction
Research Status
Safety
& evidence
Adrenomedullin
Evidence Level
Moderate human trials (Phase 1-2)
FDA Status
Research compound
Safety Overview
Adrenomedullin safety in humans is poorly characterized, with clinical data limited to observational studies and small uncontrolled trials in cardiovascular patients. Animal studies demonstrate potent vasodilatory effects that could lower blood pressure dangerously, particularly in patients on antihypertensive medications. No human pharmacokinetic studies have established safe doses, and potential for hypotension, electrolyte disturbances, and off-target vasodilation effects exists. The peptide crosses the blood-brain barrier and affects central nervous system function in animal models, raising concerns about neurological effects at higher doses.
Contraindications
- xSevere hypotension or shock states
- xConcurrent use with certain vasopressor medications
- xPregnancy and breastfeeding
- xSevere kidney or liver dysfunction
BPC-157
Evidence Level
Strong preclinical (extensive animal studies)
FDA Status
Research compound
Safety Overview
BPC-157 is a gastric pentadecapeptide with strong preclinical evidence from extensive animal studies spanning over 25 years of research. Critical limitation: BPC-157 has NOT completed Phase 3 human clinical trials. No FDA approval exists. Safety data comes primarily from rat and mouse studies, with only limited Phase 1-2 human data. Animal studies show no toxicity at therapeutic doses, but human data is insufficient for regulatory approval. The peptide is unregulated, and no standardized manufacturing or quality control requirements exist for research compounds. Individual responses may vary significantly, and serious medical supervision is essential before use, particularly if you have gastrointestinal conditions, take medications, or have pre-existing medical conditions.
Contraindications
- xPregnancy
- xBreastfeeding
- xActive cancer
- xHistory of cancer
Decision Guide
Which is
right for you?
Choose Adrenomedullin if...
- Cardiovascular health optimization
- Maintaining healthy blood pressure
- Recovery from illness or sepsis
- Tissue protection and oxygen delivery
Choose BPC-157 if...
- Injury recovery
- Post-surgery healing
- Chronic pain management
- Gut health