Peptide Comparison
AlexamorelinvsGHRP-6 (Growth Hormone Releasing Peptide-6)
A next-generation growth hormone releaser that converts to hexarelin in your body for enhanced GH, cortisol, and unique aldosterone stimulation.
A synthetic hexapeptide that signals your pituitary to release growth hormone through a unique pathway, with emerging evidence of heart-protective benefits.
At a Glance
Quick
comparison
Dose Range
Alexamorelin
100–300 mcg
GHRP-6 (Growth Hormone Releasing Peptide-6)
100–300 mcg
Frequency
Alexamorelin
Multiple times daily
GHRP-6 (Growth Hormone Releasing Peptide-6)
Multiple times daily
Administration
Alexamorelin
Subcutaneous injection
GHRP-6 (Growth Hormone Releasing Peptide-6)
Subcutaneous injection
Cycle Length
Alexamorelin
4-6 weeks
GHRP-6 (Growth Hormone Releasing Peptide-6)
8-12 weeks
Onset Speed
Alexamorelin
Moderate (1-2 weeks)
GHRP-6 (Growth Hormone Releasing Peptide-6)
Moderate (1-2 weeks)
Evidence Level
Alexamorelin
Limited human trials
GHRP-6 (Growth Hormone Releasing Peptide-6)
Limited human trials
Efficacy
Benefit
ratings
Growth Hormone Release
Hormone Axis Stimulation
Research & Innovation
Muscle Recovery and Growth
Cellular Health and Protection
Appetite and Nutrient Intake
Technical Data
Compound
specifications
Alexamorelin
Molecular Formula
C50H63N13O7
Molecular Weight
958.1 g/mol
Half-Life
Estimated 1-3 hours (rapidly metabolized to hexarelin)
Bioavailability
Active IV and orally; subcutaneous bioavailability expected moderate to good
CAS Number
196808-85-2
GHRP-6 (Growth Hormone Releasing Peptide-6)
Molecular Formula
C46H56N12O6
Molecular Weight
873.0 g/mol
Half-Life
~2.5 hours
Bioavailability
<1% oral, high subcutaneous
CAS Number
87616-84-0
Protocols
Dosing
tiers
Alexamorelin
GHRP-6 (Growth Hormone Releasing Peptide-6)
Applications
Best
suited for
Alexamorelin
Muscle Builders and Athletes
Alexamorelin's potent GH release makes it ideal for those serious about muscle gains. Its stronger ACTH response compared to hexarelin provides additional recovery benefits, though the cortisol elevation requires monitoring. The oral option is convenient for athletes avoiding injections, though subcutaneous injection remains most practical.
Research-Focused Peptide Users
If you're exploring next-generation GHS compounds, alexamorelin offers a fascinating case study: it's a prodrug that becomes hexarelin in your body, offering a unique window into peptide metabolism. This makes it valuable for understanding how compound modifications affect potency and half-life.
Synergistic Stack Enthusiasts
Alexamorelin shines when stacked with GHRH, creating synergistic GH release that exceeds either alone. It also pairs well with recovery-focused peptides like BPC-157, making it the centerpiece of comprehensive growth protocols.
GHRP-6 (Growth Hormone Releasing Peptide-6)
Athletes and Serious Trainers
If you're hitting the gym hard and want better recovery and muscle growth, GHRP-6 amplifies your body's natural GH response. This is particularly valuable during intense training phases when you want to maximize adaptation and minimize soreness. The appetite stimulation also helps you consume the calories you need to grow.
Those Exploring Novel Peptide Protocols
GHRP-6 offers a unique mechanism through the ghrelin receptor, making it valuable for users who want to explore diverse GH-stimulation pathways. It works distinctly from GHRH-based approaches and pairs well with other GH secretagogues for synergistic effects.
Longevity and Metabolic Health Enthusiasts
Growth hormone plays roles in metabolic health, body composition, and potentially aging markers. GHRP-6's emerging research on cellular protection and antioxidant activation makes it interesting for those interested in broader health optimization beyond just muscle growth.
Safety Profile
Side
effects
Alexamorelin
Common
- Increased Hunger
- Water Retention
- Injection Site Reactions
Uncommon
- Cortisol-Related Mood Changes
- Joint or Muscle Aches
Serious
- Allergic Reaction
GHRP-6 (Growth Hormone Releasing Peptide-6)
Common
- Increased Appetite
- Mild Joint or Muscle Discomfort
- Water Retention or Mild Swelling
Uncommon
- Sleep Disturbances
- Mild Dizziness or Lightheadedness
Serious
- Allergic Reaction
Research Status
Safety
& evidence
Alexamorelin
Evidence Level
Limited human trials
FDA Status
Research compound
Safety Overview
Alexamorelin is a research compound with only one small human study (6 subjects), making it much less proven than hexarelin. While it shows promise as a potent GH releaser, the limited human evidence means we don't fully understand long-term effects, optimal dosing in different populations, or rare side effects. Its unique stronger ACTH and aldosterone effects require careful monitoring. Always start low and monitor how your body responds.
Contraindications
- xActive malignancy or cancer history (GH stimulation concern)
- xUncontrolled diabetes or severe glucose dysregulation
- xSevere cardiovascular disease or unmanaged hypertension
- xPregnancy or nursing
GHRP-6 (Growth Hormone Releasing Peptide-6)
Evidence Level
Limited human trials
FDA Status
Research compound
Safety Overview
GHRP-6 has a relatively long research history dating back to 1981, with human studies demonstrating its ability to stimulate GH release. The good news is that animal safety studies show excellent tolerability at high doses, and the side effects reported are generally mild and reversible. However, it's not FDA-approved, so use is based on research evidence rather than pharmaceutical oversight. Always purchase from reputable sources and consider medical consultation, especially if you have existing health conditions.
Contraindications
- xKnown allergy or sensitivity to any component of the peptide
- xActive cancer or history of cancer without medical clearance
- xSevere cardiovascular disease or uncontrolled hypertension
- xAcute critical illness or sepsis
Decision Guide
Which is
right for you?
Choose Alexamorelin if...
- Maximizing growth hormone release for muscle building
- Cycling with other peptides for synergistic GH stack effects
- Research into next-generation GHS compounds
- Understanding prodrug metabolism in peptide design
Choose GHRP-6 (Growth Hormone Releasing Peptide-6) if...
- Building lean muscle mass and improving body composition
- Recovery from intense training programs and athletic performance
- Supporting overall metabolic health and longevity markers
- Exploring novel GH-stimulation pathways for those who respond well to peptide protocols