Peptide Comparison
ThymopoietinvsThymalin
Thymic hormone that supports T-cell development and immune function, with the active fragment thymopentin (TP-5) used in clinical research
Russian thymic peptide complex that rejuvenates immune function and supports healthy aging
At a Glance
Quick
comparison
Dose Range
Thymopoietin
50–100 mg
Thymalin
5–10 mg
Frequency
Thymopoietin
Every other day
Thymalin
Once daily
Administration
Thymopoietin
Subcutaneous injection
Thymalin
Intramuscular injection
Cycle Length
Thymopoietin
4-6 weeks
Thymalin
4-6 weeks
Onset Speed
Thymopoietin
Moderate (1-2 weeks)
Thymalin
Moderate (1-2 weeks)
Evidence Level
Thymopoietin
Limited human trials
Thymalin
Limited human trials
Efficacy
Benefit
ratings
Immune Cell Development
Post-Surgical Recovery
Cancer Immunotherapy Enhancement
Immune Restoration
Longevity Support
Disease Prevention
Technical Data
Compound
specifications
Thymopoietin
Molecular Formula
C246H404N66O73
Molecular Weight
5454
Half-Life
Minutes to hours in plasma
Bioavailability
Moderate with subcutaneous injection
CAS Number
67632-30-6
Thymalin
Molecular Formula
Complex mixture; active dipeptide EW: C16H19N3O5
Molecular Weight
Polypeptide complex; components 250-1000 Da; active dipeptide EW ~321 Da
Half-Life
Not precisely characterized for complex; immune effects persist weeks post-administration
Bioavailability
High via intramuscular or subcutaneous injection
CAS Number
63958-90-7
Protocols
Dosing
tiers
Thymopoietin
Thymalin
Applications
Best
suited for
Thymopoietin
Cancer Treatment Support
Used alongside chemotherapy to maintain immune function and reduce treatment side effects while enhancing anti-tumor immunity
Post-Surgical Immune Recovery
Helps restore T-cell function and prevent immune depression following major surgery or serious medical stress
HIV-Related Immune Support
Combined with antiretroviral therapy to support T-cell populations and improve immune response
Thymalin
Aging Adults Seeking Immune Support
Thymalin is especially valuable for people over 55 whose thymus gland has naturally shrunk with age. By stimulating thymic function, it helps restore the immune training center that your body relies on to fight infections and stay healthy.
Longevity and Anti-Aging Protocols
Clinical studies tracking patients for 6-8 years showed Thymalin reduced mortality by 2.0-2.1-fold. Combined with Epitalon, the mortality reduction reached an impressive 4.1-fold, making this combination one of the most studied longevity peptide protocols.
Seasonal Illness Prevention
Research shows Thymalin cuts respiratory infection rates by 2.0-2.4-fold. A short 10-day course before cold and flu season can significantly boost your immune defenses for months afterward.
Safety Profile
Side
effects
Thymopoietin
Common
- Injection site redness or swelling
- Mild fever
- Transient lymphocytosis
Uncommon
- Mild to moderate fatigue
- Temporary headaches
- Joint or muscle aches
Serious
- Neuromuscular weakness or myasthenia-like symptoms
- Severe allergic reaction (anaphylaxis)
- Autoimmune flare
Thymalin
Common
- No side effects in most patients
- Mild injection site reaction
Uncommon
- Transient low-grade fever
- Mild flu-like symptoms
- Temporary headache
Serious
- Severe allergic reaction
Research Status
Safety
& evidence
Thymopoietin
Evidence Level
Limited human trials
FDA Status
Research compound
Safety Overview
Thymopoietin is a naturally-derived thymic hormone with a well-characterized mechanism but limited human safety data. Most clinical experience comes from thymopentin (TP-5), the active pentapeptide fragment. It is generally well-tolerated but has important safety considerations, particularly regarding neuromuscular effects.
Contraindications
- xMyasthenia gravis or other neuromuscular junction disorders
- xActive autoimmune diseases
- xPregnancy and breastfeeding
- xSevere allergic reactions to thymic proteins
Thymalin
Evidence Level
Limited human trials
FDA Status
Research compound
Safety Overview
Thymalin has an excellent safety profile based on over 40 years of clinical use in Russia. Most patients experience zero side effects, and the peptide complex has been described as 'practically non-toxic' in research literature. It has been used safely in thousands of patients, including elderly populations over extended periods.
Contraindications
- xActive thymic tumors or malignancies
- xKnown hypersensitivity to animal-derived peptide products
- xPregnancy and breastfeeding (insufficient safety data)
- xSevere uncontrolled autoimmune disease without medical supervision
Decision Guide
Which is
right for you?
Choose Thymopoietin if...
- Supporting immune function during cancer treatment
- Recovering immune function after surgery
- Managing HIV-related immune deficiencies
- Enhancing response to other immunotherapies
Choose Thymalin if...
- Immune system restoration in aging adults
- Longevity and healthy aging support
- Reducing infection frequency and severity
- Multi-system health optimization