Peptide Comparison
TriptorelinvsLeuprolide
GnRH agonist that helps manage prostate cancer, endometriosis, and early puberty by controlling sex hormones
A powerful GnRH agonist that helps manage hormone-sensitive conditions by controlling hormone production.
At a Glance
Quick
comparison
Dose Range
Triptorelin
0.1 mg–22.5 mg mg
Leuprolide
3.75 mg–45 mg monthly or 3-month injections (depending on formulation)
Frequency
Triptorelin
Once daily
Leuprolide
Once daily
Administration
Triptorelin
Intramuscular injection
Leuprolide
Subcutaneous injection (daily)
Cycle Length
Triptorelin
Ongoing/indefinite
Leuprolide
Ongoing/indefinite
Onset Speed
Triptorelin
Moderate (1-2 weeks)
Leuprolide
Moderate (1-2 weeks)
Evidence Level
Triptorelin
Strong human trials (Phase 3 or FDA approved)
Leuprolide
Strong human trials (Phase 3 or FDA approved)
Efficacy
Benefit
ratings
Hormone Regulation
Cancer Management
Endometriosis Relief
Endometriosis & Fibroid Relief
Hormone Control
Technical Data
Compound
specifications
Triptorelin
Molecular Formula
C64H82N18O13
Molecular Weight
1311.4 g/mol
Half-Life
2-3 hours (free peptide); 2-4 weeks (depot pamoate formulations)
Bioavailability
~100% (intramuscular/subcutaneous injection)
CAS Number
57773-63-4
Leuprolide
Molecular Formula
C59H84N16O12
Molecular Weight
1209.4 g/mol
Half-Life
Approximately 2-6 hours (varies by route of administration)
Bioavailability
~95% (subcutaneous injection)
CAS Number
74381-53-6
Applications
Best
suited for
Triptorelin
Managing advanced prostate cancer when combined with other treatments
Triptorelin is particularly well-suited for individuals focused on managing advanced prostate cancer when combined with other treatments. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Relieving severe endometriosis pain and symptoms
Triptorelin is particularly well-suited for individuals focused on relieving severe endometriosis pain and symptoms. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Delaying puberty development in children with early sexual maturation
Triptorelin is particularly well-suited for individuals focused on delaying puberty development in children with early sexual maturation. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Leuprolide
Managing advanced or metastatic prostate cancer
Leuprolide is particularly well-suited for individuals focused on managing advanced or metastatic prostate cancer. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Controlling severe endometriosis pain
Leuprolide is particularly well-suited for individuals focused on controlling severe endometriosis pain. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Treating symptomatic uterine fibroids
Leuprolide is particularly well-suited for individuals focused on treating symptomatic uterine fibroids. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Delaying early puberty in children
Leuprolide is particularly well-suited for individuals focused on delaying early puberty in children. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Safety Profile
Side
effects
Triptorelin
Leuprolide
Common
- Hot flashes (very common in men)
- Decreased libido and erectile dysfunction
- Injection site pain or swelling
- Nausea
- Fatigue
- Mood changes or depression
- Joint or muscle pain
- Headaches
- Dizziness
- Thinning hair
- Decreased bone density (osteoporosis with long-term use)
- QT prolongation (rare but serious cardiac effect)
- Tumor flare (temporary worsening of cancer symptoms in first weeks)
- Severe allergic reactions
- Spinal cord compression risk in men with metastatic disease
Serious
- Severe allergic reaction
Research Status
Safety
& evidence
Triptorelin
Evidence Level
Strong human trials (Phase 3 or FDA approved)
FDA Status
FDA approved for this use
Safety Overview
Triptorelin (GnRH agonist) has extensive FDA-approved safety data spanning decades for prostate cancer, endometriosis, and precocious puberty indications. Initial testosterone surge upon initiation ("flare reaction") can worsen prostate cancer or spinal cord compression symptoms, requiring careful patient monitoring in first 1-2 weeks and use of androgen antagonists in high-risk patients. Hypogonadal effects including hot flashes, sexual dysfunction, and bone loss develop predictably with chronic GnRH suppression; bone density monitoring is recommended in patients on therapy >6 months.
Contraindications
- xPregnancy (can affect fetal development)
- xUndiagnosed vaginal bleeding
- xKnown hypersensitivity to GnRH agonists
- xSevere untreated depression
- xActive spinal cord compression in prostate cancer (requires urgent decompression)
Leuprolide
Evidence Level
Strong human trials (Phase 3 or FDA approved)
FDA Status
FDA approved for this use
Safety Overview
Leuprolide (Lupron) is an FDA-approved GnRH agonist with 35+ years of clinical safety data involving millions of patients in oncology and endocrinology. The critical safety issue is the initial 5-7 day flare effect—temporary surge in FSH/LH causing symptom worsening before hormone suppression begins—particularly dangerous for prostate cancer patients (flare can cause urinary obstruction or spinal cord compression). Bone density loss is a dose-dependent long-term risk in both men and women requiring monitoring. Injection site reactions, hot flushes, and initial hypogonadal symptoms are expected and typically transient.
Contraindications
- xPregnancy or breastfeeding (teratogenic)
- xUndiagnosed vaginal bleeding
- xActive bone metastases with spinal cord compression (increased fracture risk)
- xAllergy to GnRH agonists or components
- xSevere cardiovascular disease with QT prolongation risk
Decision Guide
Which is
right for you?
Choose Triptorelin if...
- Managing advanced prostate cancer when combined with other treatments
- Relieving severe endometriosis pain and symptoms
- Delaying puberty development in children with early sexual maturation
Choose Leuprolide if...
- Managing advanced or metastatic prostate cancer
- Controlling severe endometriosis pain
- Treating symptomatic uterine fibroids
- Delaying early puberty in children