Sleep & Recovery Protocol
DSIP (Delta Sleep-Inducing Peptide)Complete Dosing & Administration Guide
A naturally occurring brain peptide that helps you fall into deep, restorative sleep by gently nudging your body's own sleep-wake systems—without the groggy hangover of traditional sleep aids.
Dose Range
100-300mcg
Frequency
Once daily
Route
Subcutaneous injection
Cycle Length
4-6 weeks
Dosing
How much
do I take?
Starting Dose
100 mcg
Start here to see how your body responds. Many people notice improved sleep quality within the first few nights. This gentle introduction helps you gauge your sensitivity before moving up.
Standard Dose
200 mcg
The most commonly used dose for consistent sleep improvement. Research studies typically used similar amounts and found good results without significant side effects. This is where most people find their sweet spot.
Advanced Dose
300 mcg
The higher end of typical dosing. Some people with severe sleep disruption or high stress levels may benefit from this dose. Always work with a healthcare provider at this level.
Timing
Best time to take
Evening, 1-2 hours before your intended bedtime. DSIP doesn't knock you out instantly—it works with your body's natural sleep systems, so give it time to take effect.
With food?
Can be taken with or without food. Some people prefer taking it on an empty stomach for potentially faster absorption, but food doesn't block its effects.
If stacking
If using with other peptides like CJC-1295 or Ipamorelin for growth hormone support, inject at different sites. DSIP is typically taken alone in the evening while growth hormone peptides may be used at other times.
Adjusting Your Dose
Increase if
- +You've been at the current dose for 2+ weeks with minimal improvement
- +Sleep quality improved initially but has plateaued
- +No side effects at current dose and you want better results
- +Your healthcare provider recommends escalation
Decrease if
- -You experience morning grogginess or headaches
- -Sleep becomes too deep and you have trouble waking to alarms
- -Vivid dreams become disturbing rather than pleasant
- -Any uncomfortable side effects persist
Signs of right dose
- ✓Falling asleep within 20-30 minutes of lying down
- ✓Sleeping through the night with minimal waking
- ✓Waking feeling refreshed without an alarm
- ✓Improved daytime energy and mental clarity
Dosing Calculator
Calculate Your Exact Dose
Step 1: Peptide Weight
Find the weight printed on your peptide vial label
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The peptide weight is printed on the label
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The weight is on the label
Administration
How do I
use it?
Reconstitution
What you need
- •Bacteriostatic water (BAC water)
- •Insulin syringes (29-31 gauge)
- •Alcohol swabs
- •Your DSIP powder vial (typically 2mg or 5mg)
Injection
Route
Subcutaneous injection (just under the skin)—simple and effective for self-administration
Best sites
- •Abdomen (2 inches from navel)—easy access and good absorption
- •Front of thigh—convenient alternative
- •Back of upper arm—may need assistance
Technique
- 1.Wash hands thoroughly with soap and water
- 2.Clean injection site with alcohol swab and let it dry completely
- 3.Pinch a fold of skin between thumb and forefinger
- 4.Insert needle at 45-90 degree angle (45° if lean, 90° if more tissue)
- 5.Inject slowly and smoothly over 5-10 seconds
- 6.Wait a moment, then withdraw needle and apply light pressure—don't rub
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
DSIP has an excellent safety record across decades of research. In human studies, it was described as 'incredibly safe' with no lethal dose ever identified in animal studies. Side effects are generally mild and temporary—mostly headache, brief dizziness, or flushing. The peptide works by supporting natural sleep processes rather than forcing sedation, which is why it doesn't cause the dependency or withdrawal issues seen with pharmaceutical sleep aids.
DSIP has been studied in humans since the early 1980s, with multiple double-blind placebo-controlled trials. While not as extensively studied as FDA-approved medications, the available evidence shows consistent safety with meaningful benefits for sleep. Most research focused on short-to-medium term use (days to weeks).
Common Side Effects
Experienced by some users
Mild headache
The most frequently reported side effect. Usually appears within an hour of injection and resolves on its own.
Management: Stay well-hydrated. If persistent, try reducing your dose. Over-the-counter pain relievers can help if needed, but usually aren't necessary.
Brief dizziness or lightheadedness
Some people feel slightly lightheaded shortly after injection. This is usually mild and passes within 15-30 minutes.
Management: Sit or lie down after injecting until it passes. Make sure you're not injecting on an empty stomach if this bothers you.
Flushing or warmth
A temporary sensation of warmth, sometimes with mild skin flushing. Completely harmless and usually brief.
Management: This is normal and passes on its own. Stay in a comfortable environment and relax—you're about to sleep anyway!
Injection site reactions
Minor redness, tenderness, or slight swelling where you injected. Very common with any injectable.
Management: Rotate injection sites to give each area time to recover. Ensure proper injection technique. Cool compress can help if bothersome.
Less Common
- •Vivid dreams
- •Mild nausea
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Any signs of allergic reaction—hives, swelling, breathing difficulty (stop immediately, seek help)
- ×Severe or persistent headaches that don't respond to dose reduction
- ×Excessive daytime drowsiness affecting your ability to function
- ×Unusual mood changes or psychological symptoms
- ×You've completed your planned cycle (typically 4-6 weeks)
- ×Your healthcare provider recommends discontinuation
DSIP is a research peptide, not an FDA-approved medication. Always work with a qualified healthcare provider when using peptides. Never start, stop, or change doses without professional guidance. This information is educational—not medical advice.
Interactions
With other peptides
- ✓Complementary pairing—Epitalon supports melatonin production while DSIP enhances delta sleep. Often used together for comprehensive sleep and anti-aging support.
- ✓Can be used together. Growth hormone-releasing peptides benefit from better sleep quality. Use at different times of day for best results.
- ✓May enhance relaxation effects. Both have stress-modulating properties. Start with lower doses of each when combining.
- ✓No known negative interactions. BPC-157 focuses on gut and tissue healing while DSIP targets sleep—different systems.
With medications
- !Benzodiazepines (Xanax, Valium, etc.) - Both enhance sleep/sedation—combining could cause excessive drowsiness. Consult your doctor before using together.
- !Z-drugs (Ambien, Lunesta) - Similar concern as benzodiazepines—additive sedation effects. Don't combine without medical supervision.
- ✓Antidepressants - Generally considered safe, but effects on sleep architecture may vary. Inform your prescribing doctor.
- ✓Blood pressure medications - DSIP may have mild cardiovascular effects. Monitor blood pressure if using both. Likely fine but worth watching.
With supplements
- ✓Melatonin - Can be used together at low melatonin doses (0.5-1mg). Both support sleep through different pathways. Don't overdo the melatonin.
- ✓Magnesium - Excellent combination. Magnesium supports relaxation and may enhance DSIP's effects. Magnesium glycinate is particularly good for sleep.
- ✓L-theanine - Safe and potentially synergistic. L-theanine promotes relaxation without sedation, complementing DSIP's sleep-promoting effects.
- ✓Valerian root - May have additive sedation effects. If combining, start with lower doses of both to assess total effect.
- ✓High-dose GABA supplements - Theoretical overlap in mechanisms. Use caution and lower doses when combining. Monitor for excessive drowsiness.
Want the Full Picture?
View the complete DSIP (Delta Sleep-Inducing Peptide) research profile including mechanism of action, clinical studies, effectiveness timeline, and FAQ.
View Full DSIP (Delta Sleep-Inducing Peptide) Profile