Growth Hormone Protocol
CapromorelinComplete Dosing & Administration Guide
An oral ghrelin agonist originally developed by Pfizer that stimulates growth hormone and appetite. FDA-approved for veterinary use (Entyce and Elura) and investigated in human trials for age-related muscle wasting and appetite support.
Dose Range
3-30mg
Frequency
Once daily
Route
Oral (capsule or tablet)
Cycle Length
4-6 weeks
Dosing
How much
do I take?
Timing
Best time to take
Morning or evening, taken consistently at the same time each day
With food?
Can be taken with or without food; taking with a light meal may reduce nausea
If stacking
If combining with other GH-supporting supplements, space doses by at least 1-2 hours
Adjusting Your Dose
Increase if
- +No noticeable appetite improvement after 1-2 weeks at starting dose
- +GH/IGF-1 blood levels remain unchanged from baseline
Decrease if
- -Excessive appetite interfering with weight management goals
- -Persistent nausea, dizziness, or fluid retention
Signs of right dose
- ✓Healthy appetite improvement without excessive hunger
- ✓Improved energy and recovery after exercise
- ✓Measurable IGF-1 elevation on blood work
Dosing Calculator
Calculate Your Exact Dose
Step 1: Peptide Weight
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The weight is on the label
Administration
How do I
use it?
Reconstitution
What you need
- •Oral capsule or solution as supplied
- •Water for swallowing
- •Measuring syringe (for liquid form)
Injection
Route
Not applicable — Capromorelin is administered orally only
Best sites
- •Not applicable (oral administration)
Technique
- 1.Swallow capsule whole with a glass of water
- 2.If using liquid form, measure dose with provided syringe
- 3.Take at the same time each day for consistent results
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
Capromorelin was generally well-tolerated in Phase 2 human trials involving nearly 400 elderly participants. Most side effects were mild to moderate. Its FDA-approved veterinary use provides additional long-term safety data in mammalian species.
Human safety data comes primarily from a single Phase 2 trial (White et al., 2009) with 395 elderly subjects. Extensive veterinary safety data exists from FDA-approved products Entyce (dogs) and Elura (cats).
Common Side Effects
Experienced by some users
Appetite stimulation
Increased hunger and food intake. This is the intended mechanism for veterinary use but may be unwanted for some human users. Appetite increase is typically strongest in the first 2-3 weeks, then may stabilize or gradually decrease.
Management: If weight gain is undesired, monitor caloric intake closely and maintain consistent meal timing. Increase protein consumption to support lean muscle development. Consider timing dosing away from meal prep or dining triggers. Drink more water to help with satiety.
Fluid retention and weight gain
Mild to moderate water retention and lean weight gain due to GH effects. May cause temporary increase in body weight, typically 2-5 lbs over a 4-6 week cycle. Most weight gained is lean mass rather than fat, though some water retention is expected.
Management: Monitor body composition rather than just scale weight. Reduce sodium intake slightly to minimize water retention. Maintain adequate hydration. Most fluid retention resolves within 1-2 weeks post-cycle. Use compression garments if peripheral edema is bothersome.
Less Common
- •Joint and muscle aches
- •Fatigue or lethargy
- •Peripheral edema (swelling)
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Severe allergic reaction (rash, swelling, difficulty breathing)
- ×Significant blood glucose elevation that doesn't normalize
- ×Persistent nausea, vomiting, or GI distress not relieved by dose adjustment
- ×Unwanted excessive appetite or weight gain
- ×Development of peripheral edema or fluid retention
Always consult a healthcare professional before starting or stopping any peptide or research compound. This information is for educational purposes only.
Interactions
With other peptides
- ✓Synergistic GH release — GHRH stimulates via a different receptor pathway
- !Redundant mechanism — may not add benefit and could increase side effects
With medications
- !Insulin / Oral hypoglycemics - Capromorelin may elevate blood glucose; monitor closely and adjust diabetes medications as needed
- !Corticosteroids - Both affect glucose metabolism; increased hyperglycemia risk when combined
With supplements
- ✓Arginine / Ornithine - May modestly enhance GH release when combined with ghrelin agonists
- ✓Melatonin - Some evidence melatonin supports GH secretion during sleep; generally safe to combine
Want the Full Picture?
View the complete Capromorelin research profile including mechanism of action, clinical studies, effectiveness timeline, and FAQ.
View Full Capromorelin Profile