Adrenomedullin dosing & administration
A powerful vasodilatory peptide that relaxes blood vessels and helps your body maintain healthy fluid balance and blood pressure.
Written by Michael Carroll — Owner, Director of Research · Reviewed by the Peptide Initiative Research Team · Editorial standards
Dosing
How much do I take?
Intravenous: Delivered straight into a vein through a drip (IV), done by a clinician.
Bioavailability Complete (about 100%) — delivered straight into the bloodstream.
3 documented dose levels — separate regimens, not a titration schedule
5 ng/kg/min
Frequency
Continuous infusion, 8 hours per day
Duration
14 days (trial protocol)
Adrenomedullin is given as a slow drip into a vein in clinical trials, not by self-injection. This low dose was the bottom step tested for steroid-resistant ulcerative colitis. [4]
10 ng/kg/min
Frequency
Continuous infusion, 8 hours per day
Duration
14 days (trial protocol)
Middle dose tested in the ulcerative colitis trial. [4]
Timing
Best time to take
Adrenomedullin is administered intravenously in a clinical setting. Timing is determined by your healthcare provider based on the treatment protocol and your medical needs.
With food?
IV administration of Adrenomedullin is not dependent on meal timing. Your healthcare team will provide specific instructions regarding food and fluid intake around treatment sessions.
If stacking
Adrenomedullin should be used as directed by your healthcare provider. If combining with other medications or supplements, discuss potential interactions with your provider. Avoid combining with compounds that have overlapping mechanisms unless specifically guided by a medical professional.
Adjusting your dose
Increase if
- You've tolerated the current dose for the recommended period without significant side effects
- Therapeutic goals haven't been met at the current dose level
- Your healthcare provider recommends dose escalation based on your response
- Lab work or clinical assessments support a higher dose
Decrease if
- Side effects are bothersome or impacting daily life despite management strategies
- You experience any signs of an adverse reaction
- Lab results indicate the need for dose reduction
- Your healthcare provider recommends a lower dose based on your response
Signs of right dose
- Therapeutic goals being met with minimal side effects
- Stable and consistent response to treatment
- Lab values or clinical markers trending in the right direction
- Good tolerance with manageable or absent side effects
Administration
How do I use it?
Reconstitution
What you need
Injection
Route
Subcutaneous injection (into the fatty tissue just under the skin)—allows for consistent absorption and can be self-administered at home after proper training
Best sites
Storage
Before reconstitution
Store Adrenomedullin in the refrigerator at 36-46°F (2-8°C) in its original packaging. Protect from light and moisture. Do not freeze. Check the expiration date before use. Some formulations may be stored at room temperature for limited periods—check your specific product labeling.
After reconstitution
Once reconstituted, Adrenomedullin should be kept refrigerated at 36-46°F (2-8°C) and used within the timeframe specified on your product labeling (typically 14-28 days). Label the vial with the reconstitution date. Do not use if the solution appears cloudy, discolored, or contains particles.
Signs of degradation — discard the vial
Sample daily schedule
As prescribed (once daily)
As prescribed by your healthcare provider injection
Site: Intravenous infusion—rotate sites if applicable
Maintain a consistent schedule for optimal results with Adrenomedullin. Set reminders if needed. If you miss a dose, follow your healthcare provider's instructions—do not double up on doses to compensate.
Safety
Is it safe?
Side effects
Commonly reported: Mild discomfort at treatment site, Excessive blood pressure lowering (hypotension), Headaches (from pressure changes), Flushing and mild facial redness, Dizziness or lightheadedness, Mild electrolyte shifts, Localized injection site reactions, Increased urination (natriuretic effect)
Stop and seek help if
- Severe or worsening side effects that don't improve with dose adjustment or supportive care
- Signs of an allergic reaction—rash, hives, swelling, or difficulty breathing
- Your healthcare provider recommends discontinuation based on your clinical response
- Development of any new medical condition that may be contraindicated with Adrenomedullin
- Pregnancy or planning to become pregnant (unless specifically approved for use during pregnancy)
- Abnormal lab results or clinical markers that suggest adverse effects
Adrenomedullin should only be started, adjusted, or discontinued under medical supervision. This information is for educational purposes only and does not replace professional medical advice. Never stop a prescribed treatment without consulting your healthcare provider first, as abrupt discontinuation may have consequences.
Flagged pairings
- High-dose vasopressor medications — Use with caution—discuss with your healthcare provider.
- Severe dehydration therapies — Use with caution—discuss with your healthcare provider.
- Unmonitored blood pressure conditions — Use with caution—discuss with your healthcare provider.
Published research
What the studies show
Risso C, Vay L, Sciascia F · 2025
Mid-regional pro-adrenomedullin proved valuable for detecting endothelial dysfunction and predicting organ failure after heart surgery. Patients with infections showed elevated pro-adrenomedullin levels, while those with routine surgery maintained normal levels, making it an excellent early warning marker.
Sacco MA, Gualtieri S, Cordasco F · 2024
Elevated adrenomedullin levels consistently correlated with increased risk of death and severe complications across many diseases. This vasodilatory peptide serves as a powerful prognostic marker for patient stratification and therapeutic effectiveness monitoring.
Kitamura K, Kangawa K, Kawamoto M, et al. · 1993
This landmark discovery identified adrenomedullin as a novel 52-amino acid hormone with potent and long-lasting blood pressure-lowering effects. The peptide circulates in considerable concentrations and represents a new physiological system for circulation control alongside traditional hormone pathways.
Ashizuka S, Kuroki M, Yamato T, et al. · 2021
28 patients with steroid-resistant UC received IV infusion of 5, 10, or 15 ng/kg/min adrenomedullin or placebo for 8 hours per day for 14 days; the 15 ng/kg/min (high-dose) group showed significantly improved Mayo score and clinical remission.
Kita T, Kaji Y, Kitamura K · 2020
Healthy males received continuous IV infusion of placebo, 3, 9, or 15 ng/kg/min adrenomedullin over 12 hours, or 15 ng/kg/min for 8 hours/day over 7 days; infusions were generally well tolerated with mild vasodilatory effects.
Head to head
Adrenomedullin compared
Want the full picture?
The complete Adrenomedullin research profile: mechanism of action, clinical studies, effectiveness timeline, and FAQ.