Peptide Comparison
FertirelinvsTriptorelin
A potent GnRH analog designed to support reproductive function in veterinary and research settings
GnRH agonist that helps manage prostate cancer, endometriosis, and early puberty by controlling sex hormones
At a Glance
Quick
comparison
Dose Range
Fertirelin
25 micrograms–100 micrograms mg
Triptorelin
0.1 mg–22.5 mg mg
Frequency
Fertirelin
Once daily
Triptorelin
Once daily
Administration
Fertirelin
Intramuscular injection
Triptorelin
Intramuscular injection
Cycle Length
Fertirelin
Ongoing/indefinite
Triptorelin
Ongoing/indefinite
Onset Speed
Fertirelin
Moderate (1-2 weeks)
Triptorelin
Moderate (1-2 weeks)
Evidence Level
Fertirelin
Moderate human trials (Phase 1-2)
Triptorelin
Strong human trials (Phase 3 or FDA approved)
Efficacy
Benefit
ratings
Reproductive Synchronization
Hormone Support
Veterinary Breeding Enhancement
Hormone Regulation
Cancer Management
Endometriosis Relief
Technical Data
Compound
specifications
Fertirelin
Molecular Formula
C55H76N16O12
Molecular Weight
1153.3 g/mol
Half-Life
Variable depending on formulation; sustained-release formulations extend duration
Bioavailability
High when administered via injection
CAS Number
66002-66-2
Triptorelin
Molecular Formula
C64H82N18O13
Molecular Weight
1311.4 g/mol
Half-Life
2-3 hours (free peptide); 2-4 weeks (depot pamoate formulations)
Bioavailability
~100% (intramuscular/subcutaneous injection)
CAS Number
57773-63-4
Applications
Best
suited for
Fertirelin
Livestock breeding programs
Fertirelin is particularly well-suited for individuals focused on livestock breeding programs. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Reproductive synchronization in cattle
Fertirelin is particularly well-suited for individuals focused on reproductive synchronization in cattle. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Fertility enhancement in veterinary settings
Fertirelin is particularly well-suited for individuals focused on fertility enhancement in veterinary settings. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Research on reproductive hormone mechanisms
Fertirelin is particularly well-suited for individuals focused on research on reproductive hormone mechanisms. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Triptorelin
Managing advanced prostate cancer when combined with other treatments
Triptorelin is particularly well-suited for individuals focused on managing advanced prostate cancer when combined with other treatments. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Relieving severe endometriosis pain and symptoms
Triptorelin is particularly well-suited for individuals focused on relieving severe endometriosis pain and symptoms. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Delaying puberty development in children with early sexual maturation
Triptorelin is particularly well-suited for individuals focused on delaying puberty development in children with early sexual maturation. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Safety Profile
Side
effects
Fertirelin
Common
- Mild discomfort at treatment site
- Transient hormone fluctuations
- Temporary behavioral changes in animals
- Mild injection site reactions
- Short-term changes in appetite
- Temporary mood variations
- Minimal systemic effects at therapeutic doses
Uncommon
- Occasional swelling at injection site
Serious
- Severe allergic reaction
Triptorelin
Research Status
Safety
& evidence
Fertirelin
Evidence Level
Moderate human trials (Phase 1-2)
FDA Status
Research compound
Safety Overview
Fertirelin is a GnRH agonist developed specifically for veterinary use in livestock, particularly cattle breeding and fertility management. The peptide has been safely used in veterinary medicine for over 40 years with a well-documented safety profile in animals. Important limitation: Fertirelin is NOT approved for human use. All safety and efficacy data comes from veterinary applications in cattle and limited laboratory research. Human safety data is minimal and extrapolation from veterinary use is problematic. The biphasic response (initial hormone surge followed by suppression) must be carefully managed in any application. Individual responses can vary significantly based on age, hormonal status, and concurrent medications.
Contraindications
- xPregnancy (may disrupt existing pregnancy)
- xHypersensitivity to GnRH analogs
- xActive reproductive infections
- xConcurrent use with certain medications
- xUndiagnosed reproductive disorders
Triptorelin
Evidence Level
Strong human trials (Phase 3 or FDA approved)
FDA Status
FDA approved for this use
Safety Overview
Triptorelin (GnRH agonist) has extensive FDA-approved safety data spanning decades for prostate cancer, endometriosis, and precocious puberty indications. Initial testosterone surge upon initiation ("flare reaction") can worsen prostate cancer or spinal cord compression symptoms, requiring careful patient monitoring in first 1-2 weeks and use of androgen antagonists in high-risk patients. Hypogonadal effects including hot flashes, sexual dysfunction, and bone loss develop predictably with chronic GnRH suppression; bone density monitoring is recommended in patients on therapy >6 months.
Contraindications
- xPregnancy (can affect fetal development)
- xUndiagnosed vaginal bleeding
- xKnown hypersensitivity to GnRH agonists
- xSevere untreated depression
- xActive spinal cord compression in prostate cancer (requires urgent decompression)
Decision Guide
Which is
right for you?
Choose Fertirelin if...
- Livestock breeding programs
- Reproductive synchronization in cattle
- Fertility enhancement in veterinary settings
- Research on reproductive hormone mechanisms
Choose Triptorelin if...
- Managing advanced prostate cancer when combined with other treatments
- Relieving severe endometriosis pain and symptoms
- Delaying puberty development in children with early sexual maturation