Immune Protocol
VilonComplete Dosing & Administration Guide
Immunomodulatory dipeptide bioregulator (Lys-Glu) that upregulates SIRT1 expression 6-fold through direct DNA promoter binding, activates T-cell differentiation via sphingomyelin signaling, and reduces pro-inflammatory cytokines by up to 6-fold as a natural inducer of TNF tolerance
Dose Range
5-10mg
Frequency
Once daily
Route
Subcutaneous injection
Cycle Length
12+ weeks
Dosing
How much
do I take?
Starting Dose
200-500 mcg subcutaneously once daily
Begin with the conservative research protocol. Reconstitute lyophilized Vilon in bacteriostatic water or physiological saline. Administer subcutaneously, rotating injection sites. This ultra-short dipeptide is rapidly absorbed. Effects are gradual — immune and epigenetic changes build over the treatment course. Monitor for any injection site reactions.
Standard Dose
5 mg subcutaneously once daily
Standard clinical protocol used in Russian bioregulator therapy. Administer subcutaneously once daily for 5-10 consecutive days. Repeat courses every 3-6 months for sustained immune and geroprotective benefits. Can be combined with Epithalon for comprehensive anti-aging or with Vladonix for enhanced immune support. The SIRT1 upregulation and PARP downregulation initiated during treatment persist beyond the active course.
Advanced Dose
10 mg subcutaneously once daily
Extended protocol for individuals with significant immune compromise or advanced age. Used in clinical studies as adjuvant therapy for cancer patients alongside radio/chemotherapy. Often combined with complementary bioregulators: Thymalin for full-spectrum thymic support, Epithalon for pineal/melatonin function, and Cerluten for neuroprotection. Repeat courses every 3-6 months. Medical supervision recommended for advanced protocols.
Timing
Best time to take
Administer Vilon at the same time each day (or on the same day each week for weekly injections). Many users prefer morning or evening administration. Pick a time you'll remember consistently.
With food?
Vilon injections can be given regardless of meal timing. However, if GI effects occur, administering on an empty stomach or with a light meal may help reduce discomfort.
If stacking
Vilon should be used as directed by your healthcare provider. If combining with other medications or supplements, discuss potential interactions with your provider. Avoid combining with compounds that have overlapping mechanisms unless specifically guided by a medical professional.
Adjusting Your Dose
Increase if
- +You've tolerated the current dose for the recommended period without significant side effects
- +Therapeutic goals haven't been met at the current dose level
- +Your healthcare provider recommends dose escalation based on your response
- +Lab work or clinical assessments support a higher dose
Decrease if
- -Side effects are bothersome or impacting daily life despite management strategies
- -You experience any signs of an adverse reaction
- -Lab results indicate the need for dose reduction
- -Your healthcare provider recommends a lower dose based on your response
Signs of right dose
- ✓Therapeutic goals being met with minimal side effects
- ✓Stable and consistent response to treatment
- ✓Lab values or clinical markers trending in the right direction
- ✓Good tolerance with manageable or absent side effects
Dosing Calculator
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Administration
How do I
use it?
Reconstitution
What you need
- •Vilon vial (lyophilized powder or solution)
- •Bacteriostatic water or sterile sodium chloride for reconstitution
- •Alcohol swabs for cleaning vial tops and injection sites
- •Appropriately sized syringes with fine-gauge needles (27-30 gauge)
- •Sharps disposal container
Injection
Route
Subcutaneous injection (into the fatty tissue just under the skin)—allows for consistent absorption and can be self-administered at home after proper training
Best sites
- •Abdomen (stomach area)—at least 2 inches from the belly button, most popular choice for self-injection
- •Front of thighs—middle to upper portion of the outer leg
- •Back of upper arm—outer area (may need assistance from another person)
Technique
- 1.Wash your hands thoroughly with soap and water before handling supplies
- 2.Clean the injection site with an alcohol swab and let it air dry completely
- 3.Pinch a fold of skin at the chosen injection site
- 4.Insert the needle at a 45-90 degree angle (depending on needle length and body composition)
- 5.Inject the medication slowly and steadily over 5-10 seconds
- 6.Release the skin fold and remove the needle, applying gentle pressure with a clean swab
- 7.Rotate injection sites to prevent tissue irritation or lipodystrophy
- 8.Dispose of the needle safely in a sharps container—never recap or reuse needles
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
Vilon (immunomodulatory thymic peptide complex from bovine thymus) demonstrates favorable safety in Russian/Eastern European medical use over 20+ years with minimal documented serious adverse events in published literature. Bovine-derived peptide preparations carry theoretical prion disease risk (variant Creutzfeldt-Jakob disease) though processing methods and regulatory standards substantially reduce this risk. Common adverse effects are mild—local injection site reactions, transient fever, or lymphadenopathy—consistent with immune system stimulation rather than toxicity.
Safety data comes primarily from Russian clinical experience and unpublished manufacturer studies; limited peer-reviewed Western data exists. No Phase 3 controlled efficacy trials have been published in major journals. Immunostimulatory mechanism could theoretically exacerbate autoimmune conditions, requiring baseline immune status assessment. Long-term safety beyond 2-3 months of use is incompletely characterized in English-language literature.
Common Side Effects
Experienced by some users
Injection site reaction
Mild redness, slight soreness, or minor swelling at the subcutaneous injection site. Common with injectable peptide bioregulators.
Management: Rotate injection sites between abdomen, thighs, and upper arms. Apply cold compress if needed. Resolves spontaneously within 24-48 hours.
Mild fatigue
Slight fatigue during the initial days as the immune system recalibrates in response to enhanced T-cell activation and cytokine modulation.
Management: Rest as needed. Usually resolves within 2-3 days. Ensure adequate sleep and hydration.
Mild headache
Transient headache during the first few days of treatment, potentially related to immune activation and cytokine level changes.
Management: Ensure adequate hydration. Standard analgesics if needed. Usually self-limiting.
Digestive changes
Mild gastrointestinal changes (increased digestive activity, slight changes in bowel habits) reflecting Vilon's enhancement of digestive enzyme activity throughout the GI tract.
Management: Generally benign — indicates active enzyme normalization. Eat regular meals. Should stabilize within days.
Less Common
- •Flu-like symptoms
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Severe or worsening side effects that don't improve with dose adjustment or supportive care
- ×Signs of an allergic reaction—rash, hives, swelling, or difficulty breathing
- ×Your healthcare provider recommends discontinuation based on your clinical response
- ×Development of any new medical condition that may be contraindicated with Vilon
- ×Pregnancy or planning to become pregnant (unless specifically approved for use during pregnancy)
- ×Abnormal lab results or clinical markers that suggest adverse effects
Vilon should only be started, adjusted, or discontinued under medical supervision. This information is for educational purposes only and does not replace professional medical advice. Never stop a prescribed treatment without consulting your healthcare provider first, as abrupt discontinuation may have consequences.
Interactions
With other peptides
- ✓May be used together under medical guidance.
- ✓May be used together under medical guidance.
- ✓May be used together under medical guidance.
With medications
- !Immunosuppressive medications (cyclosporine, tacrolimus, mycophenolate) — Vilon's immunostimulatory effects may counteract immunosuppression - Use with caution—discuss with your healthcare provider.
- !High-dose corticosteroids — may interfere with Vilon's T-cell activation and cytokine regulation mechanisms - Use with caution—discuss with your healthcare provider.
- !Other potent immunostimulants at high doses without medical supervision — risk of immune overactivation - Use with caution—discuss with your healthcare provider.
With supplements
- ✓Multivitamins - Generally safe to take alongside Vilon. Space doses apart if taking oral formulations to ensure optimal absorption.
- ✓Electrolyte supplements - Helpful if experiencing any GI side effects that could lead to dehydration. Safe to combine.
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