Metabolic Protocol
PancragenComplete Dosing & Administration Guide
Tetrapeptide bioregulator (Lys-Glu-Asp-Trp) that binds ACCT sequences in pancreatic gene promoters with 3-fold greater affinity than related peptides, stimulates beta-cell differentiation through Pdx1/Pax6/NGN3 transcription factor activation, and corrects impaired glucose tolerance in primates more physiologically than glimepiride
Dose Range
50-500mcg
Frequency
Multiple times daily
Route
Intramuscular injection
Cycle Length
8-12 weeks
Dosing
How much
do I take?
Starting Dose
50 mcg intramuscularly once daily
Conservative research protocol based on the rhesus monkey studies (0.05 mg/animal/day for 10 days IM). Reconstitute lyophilized Pancragen in saline. Administer intramuscularly. At this dose, effects on pancreatic endocrine function were demonstrated in primates — normalizing insulin and C-peptide dynamics. Monitor fasting blood glucose. Effects are gradual and may persist weeks after the course ends.
Standard Dose
500 mcg orally twice daily (Pankragen-Forte)
Clinical protocol from the human trial in prediabetic elderly patients. Oral capsule administration of Pankragen-Forte 500 mcg twice daily for 4 weeks. In the clinical study, 50% of patients showed significant glucose improvement with concurrent benefits in insulin resistance, beta-cell function, lipid profiles, and endothelial function. Repeat courses every 3-6 months.
Advanced Dose
500 mcg-1 mg orally twice daily or 100 mcg intramuscularly once daily
Extended protocol for individuals with established impaired glucose tolerance or metabolic syndrome. Combines the clinical oral dosing with potential injectable courses for more pronounced effects. Often part of comprehensive Khavinson bioregulator programs alongside Livagen for liver support and Epithalon for neuroendocrine function. Medical supervision essential for monitoring glucose and insulin levels.
Timing
Best time to take
Administer Pancragen at the same time each day (or on the same day each week for weekly injections). Many users prefer morning or evening administration. Pick a time you'll remember consistently.
With food?
Pancragen injections can be given regardless of meal timing. However, if GI effects occur, administering on an empty stomach or with a light meal may help reduce discomfort.
If stacking
Pancragen should be used as directed by your healthcare provider. If combining with other medications or supplements, discuss potential interactions with your provider. Avoid combining with compounds that have overlapping mechanisms unless specifically guided by a medical professional.
Adjusting Your Dose
Increase if
- +You've tolerated the current dose for the recommended period without significant side effects
- +Therapeutic goals haven't been met at the current dose level
- +Your healthcare provider recommends dose escalation based on your response
- +Lab work or clinical assessments support a higher dose
Decrease if
- -Side effects are bothersome or impacting daily life despite management strategies
- -You experience any signs of an adverse reaction
- -Lab results indicate the need for dose reduction
- -Your healthcare provider recommends a lower dose based on your response
Signs of right dose
- ✓Therapeutic goals being met with minimal side effects
- ✓Stable and consistent response to treatment
- ✓Lab values or clinical markers trending in the right direction
- ✓Good tolerance with manageable or absent side effects
Dosing Calculator
Calculate Your Exact Dose
Step 1: Peptide Weight
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Administration
How do I
use it?
Reconstitution
What you need
- •Pancragen vial (lyophilized powder or solution)
- •Bacteriostatic water or sterile sodium chloride for reconstitution
- •Alcohol swabs for cleaning vial tops and injection sites
- •Appropriately sized syringes with fine-gauge needles (27-30 gauge)
- •Sharps disposal container
Injection
Route
Subcutaneous injection (into the fatty tissue just under the skin)—allows for consistent absorption and can be self-administered at home after proper training
Best sites
- •Abdomen (stomach area)—at least 2 inches from the belly button, most popular choice for self-injection
- •Front of thighs—middle to upper portion of the outer leg
- •Back of upper arm—outer area (may need assistance from another person)
Technique
- 1.Wash your hands thoroughly with soap and water before handling supplies
- 2.Clean the injection site with an alcohol swab and let it air dry completely
- 3.Pinch a fold of skin at the chosen injection site
- 4.Insert the needle at a 45-90 degree angle (depending on needle length and body composition)
- 5.Inject the medication slowly and steadily over 5-10 seconds
- 6.Release the skin fold and remove the needle, applying gentle pressure with a clean swab
- 7.Rotate injection sites to prevent tissue irritation or lipodystrophy
- 8.Dispose of the needle safely in a sharps container—never recap or reuse needles
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
Pancragen shows favorable safety profile in preclinical toxicology studies with no serious adverse events at therapeutic doses. As a multi-peptide complex derived from pancreatic tissue, potential allergenicity risk exists in porcine-sensitive individuals. Gastrointestinal tolerance is excellent when taken orally. Limited human clinical data; primarily used in clinical practice in Central/Eastern Europe with reported safety in observational studies.
Biochemical characterization via HPLC/mass spectrometry identifies 40+ bioactive peptide fragments with proven digestive enzyme activity. Enzymatic activity preserved through standardized extraction; protease activity confirmed through gelatin degradation assays. Safety monitoring in practice-based observational studies spanning 25+ years reports no serious adverse events in >50,000 patient-years of use.
Common Side Effects
Experienced by some users
Injection site reaction
Mild redness or slight soreness at the intramuscular injection site. Typical of injectable peptide bioregulators. Not applicable to oral Pankragen-Forte formulation.
Management: Rotate injection sites. Apply cold compress if needed. Resolves within 24-48 hours.
Mild fatigue
Transient fatigue during initial treatment as pancreatic gene expression programs recalibrate and metabolic function adjusts.
Management: Rest as needed. Usually resolves within 2-3 days. Ensure adequate nutrition and hydration.
Mild headache
Occasional headache during the adjustment period, potentially related to metabolic and glucose regulation changes.
Management: Ensure adequate hydration. Standard analgesics if needed. Self-limiting.
Minor digestive changes
Mild gastrointestinal adjustments as pancreatic enzyme activity normalizes, particularly with oral capsule formulation.
Management: Take with food if needed. Typically mild and self-resolving.
Less Common
- •Mild hypoglycemia
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Severe or worsening side effects that don't improve with dose adjustment or supportive care
- ×Signs of an allergic reaction—rash, hives, swelling, or difficulty breathing
- ×Your healthcare provider recommends discontinuation based on your clinical response
- ×Development of any new medical condition that may be contraindicated with Pancragen
- ×Pregnancy or planning to become pregnant (unless specifically approved for use during pregnancy)
- ×Abnormal lab results or clinical markers that suggest adverse effects
Pancragen should only be started, adjusted, or discontinued under medical supervision. This information is for educational purposes only and does not replace professional medical advice. Never stop a prescribed treatment without consulting your healthcare provider first, as abrupt discontinuation may have consequences.
Interactions
With other peptides
- ✓May be used together under medical guidance.
- ✓May be used together under medical guidance.
- ✓May be used together under medical guidance.
With medications
- !Sulfonylureas (glimepiride, glipizide, glyburide) without medical supervision — risk of additive hypoglycemia from combined beta-cell stimulation - Use with caution—discuss with your healthcare provider.
- !Exogenous insulin without dose adjustment — Pancragen's effects on endogenous insulin production may alter insulin requirements - Use with caution—discuss with your healthcare provider.
- !Other potent insulin secretagogues at full doses without monitoring blood glucose - Use with caution—discuss with your healthcare provider.
With supplements
- ✓Multivitamins - Generally safe to take alongside Pancragen. Space doses apart if taking oral formulations to ensure optimal absorption.
- ✓Electrolyte supplements - Helpful if experiencing any GI side effects that could lead to dehydration. Safe to combine.
Want the Full Picture?
View the complete Pancragen research profile including mechanism of action, clinical studies, effectiveness timeline, and FAQ.
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