Cognitive Protocol
N-Acetyl SelankComplete Dosing & Administration Guide
Acetylated tuftsin analogue heptapeptide with enhanced stability and anxiolytic, nootropic, and immunomodulatory properties acting through GABAergic modulation and BDNF upregulation
Dose Range
0.15-0.5mg
Frequency
Once daily
Route
Intranasal spray
Cycle Length
4-6 weeks
Dosing
How much
do I take?
Starting Dose
0.15-0.25 mg per dose, once daily
Begin with the lower dose to assess individual response. Intranasal spray is the most common and convenient route. Administer in the morning for anxiolytic and cognitive benefits throughout the day. N-Acetyl Selank has improved bioavailability compared to native Selank, so start conservatively. Nasal mucosa should be clear for optimal absorption.
Standard Dose
0.25-0.5 mg per dose, 1-2 times daily
The standard therapeutic range based on parent Selank clinical protocols. Split dosing (morning and early afternoon) may provide more consistent anxiolytic coverage throughout the day. Avoid late evening dosing as cognitive-stimulating effects may interfere with sleep onset. Repeat courses can be administered after a 1-2 week break between cycles.
Advanced Dose
0.5-0.75 mg per dose, 2 times daily
Higher doses based on advanced research protocols. N-Acetyl Selank's enhanced stability means higher doses produce more sustained effects. Monitor closely for excessive sedation or drowsiness. Subcutaneous injection may provide more precise dosing at this level. Maintain mandatory 1-2 week breaks between treatment courses. Not recommended without prior experience with standard doses.
Timing
Best time to take
Administer N-Acetyl Selank nasal spray at the same time each day. Morning dosing is commonly preferred. Blow your nose gently before administration to clear the nasal passages.
With food?
N-Acetyl Selank nasal administration is not significantly affected by food. However, some users find it more comfortable to use on an empty stomach to avoid any potential nausea.
If stacking
N-Acetyl Selank should be used as directed by your healthcare provider. If combining with other medications or supplements, discuss potential interactions with your provider. Avoid combining with compounds that have overlapping mechanisms unless specifically guided by a medical professional.
Adjusting Your Dose
Increase if
- +You've tolerated the current dose for the recommended period without significant side effects
- +Therapeutic goals haven't been met at the current dose level
- +Your healthcare provider recommends dose escalation based on your response
- +Lab work or clinical assessments support a higher dose
Decrease if
- -Side effects are bothersome or impacting daily life despite management strategies
- -You experience any signs of an adverse reaction
- -Lab results indicate the need for dose reduction
- -Your healthcare provider recommends a lower dose based on your response
Signs of right dose
- ✓Therapeutic goals being met with minimal side effects
- ✓Stable and consistent response to treatment
- ✓Lab values or clinical markers trending in the right direction
- ✓Good tolerance with manageable or absent side effects
Dosing Calculator
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Administration
How do I
use it?
Reconstitution
What you need
- •N-Acetyl Selank vial (lyophilized powder or solution)
- •Bacteriostatic water or sterile sodium chloride for reconstitution
- •Alcohol swabs for cleaning vial tops and injection sites
- •Appropriately sized syringes with fine-gauge needles (27-30 gauge)
- •Sharps disposal container
Injection
Route
Subcutaneous injection (into the fatty tissue just under the skin)—allows for consistent absorption and can be self-administered at home after proper training
Best sites
- •Abdomen (stomach area)—at least 2 inches from the belly button, most popular choice for self-injection
- •Front of thighs—middle to upper portion of the outer leg
- •Back of upper arm—outer area (may need assistance from another person)
Technique
- 1.Wash your hands thoroughly with soap and water before handling supplies
- 2.Clean the injection site with an alcohol swab and let it air dry completely
- 3.Pinch a fold of skin at the chosen injection site
- 4.Insert the needle at a 45-90 degree angle (depending on needle length and body composition)
- 5.Inject the medication slowly and steadily over 5-10 seconds
- 6.Release the skin fold and remove the needle, applying gentle pressure with a clean swab
- 7.Rotate injection sites to prevent tissue irritation or lipodystrophy
- 8.Dispose of the needle safely in a sharps container—never recap or reuse needles
Storage
Signs of degradation
Sample Daily Schedule
Safety
Is it
safe?
Safety Profile
N-Acetyl Selank demonstrates favorable safety in preclinical and clinical research with no serious adverse events at therapeutic doses. The acetylation modification enhances metabolic stability compared to native Selank while maintaining its anxiolytic efficacy. Primary safety considerations include mild nasal irritation (with intranasal administration), transient headaches in early treatment, and unpredictable immunomodulatory effects in autoimmune populations, requiring careful patient selection.
Russian clinical research spanning two decades and multiple peer-reviewed publications document N-Acetyl Selank's GABAergic mechanism through radioligand displacement assays and BDNF upregulation via Western blot analysis. Limited Western clinical data exists, but available evidence from Phase II trials in anxiety and cognitive dysfunction shows tolerability comparable to placebo with BDNF expression increases of 150-300% in hippocampal tissue.
Common Side Effects
Experienced by some users
Nasal irritation
Mild irritation, dryness, or tingling sensation in the nasal passages with intranasal administration. This is the most frequently reported side effect and is generally well-tolerated.
Management: Use a saline nasal spray 5-10 minutes before administration to moisturize nasal mucosa. Alternate nostrils between doses. If irritation persists, consider subcutaneous administration route.
Transient headache
Mild headache during the first 1-3 days of use, likely related to initial changes in GABAergic and serotonergic neurotransmission as the brain adjusts to enhanced GABAA receptor modulation.
Management: Usually self-resolving within the first few days. Ensure adequate hydration. Standard OTC analgesics are appropriate if needed. Reduce dose temporarily if headache persists.
Mild drowsiness or fatigue
Increased sense of calm that may manifest as mild drowsiness in some individuals, particularly at higher doses. This reflects the enhanced GABAergic tone from allosteric GABAA receptor modulation.
Management: Adjust dosing to morning administration if drowsiness occurs. Reduce dose if drowsiness impairs daily function. This effect often diminishes with continued use as the system adapts.
Vivid dreams
Enhanced dream vividness and recall, consistent with increased hippocampal BDNF expression and enhanced memory consolidation processes during sleep.
Management: Generally benign and may indicate active neuroplasticity. Avoid evening dosing if dreams become disruptive. Not typically a reason to discontinue.
Appetite changes
Temporary changes in appetite — either mild increase or decrease — during the first week of use. Likely related to serotonergic modulation effects.
Management: Maintain regular meal patterns. Effect is typically transient and normalizes within 5-7 days.
Less Common
- •Nasal congestion or epistaxis
These typically resolve with continued use or dose adjustment.
Stop and Seek Help If
- ×Severe or worsening side effects that don't improve with dose adjustment or supportive care
- ×Signs of an allergic reaction—rash, hives, swelling, or difficulty breathing
- ×Your healthcare provider recommends discontinuation based on your clinical response
- ×Development of any new medical condition that may be contraindicated with N-Acetyl Selank
- ×Pregnancy or planning to become pregnant (unless specifically approved for use during pregnancy)
- ×Abnormal lab results or clinical markers that suggest adverse effects
N-Acetyl Selank should only be started, adjusted, or discontinued under medical supervision. This information is for educational purposes only and does not replace professional medical advice. Never stop a prescribed treatment without consulting your healthcare provider first, as abrupt discontinuation may have consequences.
Interactions
With other peptides
- ✓May be used together under medical guidance.
- ✓May be used together under medical guidance.
- ✓May be used together under medical guidance.
With medications
- !Benzodiazepines — additive GABAergic effects may cause excessive sedation (Selank enhances diazepam effects as shown in research) - Use with caution—discuss with your healthcare provider.
- !Strong sedatives or CNS depressants — risk of potentiated sedation through combined GABAergic mechanisms - Use with caution—discuss with your healthcare provider.
- !Immunosuppressive drugs — may interfere with Selank's immunomodulatory properties - Use with caution—discuss with your healthcare provider.
With supplements
- ✓Multivitamins - Generally safe to take alongside N-Acetyl Selank. Space doses apart if taking oral formulations to ensure optimal absorption.
- ✓Electrolyte supplements - Helpful if experiencing any GI side effects that could lead to dehydration. Safe to combine.
Want the Full Picture?
View the complete N-Acetyl Selank research profile including mechanism of action, clinical studies, effectiveness timeline, and FAQ.
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