Hormone Support Protocol

Gonadorelin (GnRH)Complete Dosing & Administration Guide

The master hormone that controls your reproductive system and fertility

Dose Range

0.1-1.5-3-10mg

Frequency

Once daily

Route

Subcutaneous injection

Cycle Length

Ongoing/indefinite

Dosing

How much
do I take?

Timing

Best time to take

Administer Gonadorelin (GnRH) at the same time each day (or on the same day each week for weekly injections). Many users prefer morning or evening administration. Pick a time you'll remember consistently.

With food?

Gonadorelin (GnRH) injections can be given regardless of meal timing. However, if GI effects occur, administering on an empty stomach or with a light meal may help reduce discomfort.

If stacking

Gonadorelin (GnRH) should be used as directed by your healthcare provider. If combining with other medications or supplements, discuss potential interactions with your provider. Avoid combining with compounds that have overlapping mechanisms unless specifically guided by a medical professional.

Adjusting Your Dose

Increase if

+You've tolerated the current dose for the recommended period without significant side effects
+Therapeutic goals haven't been met at the current dose level
+Your healthcare provider recommends dose escalation based on your response
+Lab work or clinical assessments support a higher dose

Decrease if

-Side effects are bothersome or impacting daily life despite management strategies
-You experience any signs of an adverse reaction
-Lab results indicate the need for dose reduction
-Your healthcare provider recommends a lower dose based on your response

Signs of right dose

✓Therapeutic goals being met with minimal side effects
✓Stable and consistent response to treatment
✓Lab values or clinical markers trending in the right direction
✓Good tolerance with manageable or absent side effects

Dosing Calculator

Calculate Your Exact Dose

Step 1: Peptide Weight

Find the weight printed on your peptide vial label

Look here!

The peptide weight is printed on the label

5mg

Look here!

The weight is on the label

5mg

Select Weight

Look for a number followed by 'mg' on the vial label (e.g., 5mg, 10mg)

Administration

How do I
use it?

Reconstitution

What you need

•Gonadorelin (GnRH) vial (lyophilized powder or solution)
•Bacteriostatic water or sterile sodium chloride for reconstitution
•Alcohol swabs for cleaning vial tops and injection sites
•Appropriately sized syringes with fine-gauge needles (27-30 gauge)
•Sharps disposal container

Example

Add the recommended volume of bacteriostatic water to the Gonadorelin (GnRH) vial. Gently swirl (do not shake) until the powder is fully dissolved. The resulting solution should be clear. Calculate your individual dose based on the concentration and your prescribed amount.

Your dose of Gonadorelin (GnRH) is determined by your healthcare provider. Using an insulin syringe marked in units, draw up the exact amount prescribed. For example, if the reconstituted concentration is 1mg/mL and your dose is 0.5mg, draw up 0.5mL (50 units on an insulin syringe). Always double-check calculations before injection.

Full Reconstitution Guide

Injection

Route

Subcutaneous injection (into the fatty tissue just under the skin)—allows for consistent absorption and can be self-administered at home after proper training

Best sites

•Abdomen (stomach area)—at least 2 inches from the belly button, most popular choice for self-injection
•Front of thighs—middle to upper portion of the outer leg
•Back of upper arm—outer area (may need assistance from another person)

Technique

1.Wash your hands thoroughly with soap and water before handling supplies
2.Clean the injection site with an alcohol swab and let it air dry completely
3.Pinch a fold of skin at the chosen injection site
4.Insert the needle at a 45-90 degree angle (depending on needle length and body composition)
5.Inject the medication slowly and steadily over 5-10 seconds
6.Release the skin fold and remove the needle, applying gentle pressure with a clean swab
7.Rotate injection sites to prevent tissue irritation or lipodystrophy
8.Dispose of the needle safely in a sharps container—never recap or reuse needles

Full Injection Guide

Storage

Before reconstitution

Store Gonadorelin (GnRH) in the refrigerator at 36-46°F (2-8°C) in its original packaging. Protect from light and moisture. Do not freeze. Check the expiration date before use. Some formulations may be stored at room temperature for limited periods—check your specific product labeling.

After reconstitution

Once reconstituted, Gonadorelin (GnRH) should be kept refrigerated at 36-46°F (2-8°C) and used within the timeframe specified on your product labeling (typically 14-28 days). Label the vial with the reconstitution date. Do not use if the solution appears cloudy, discolored, or contains particles.

Signs of degradation

Solution appears cloudy, discolored, or contains visible particles (should be clear)
Product has been exposed to temperatures outside the recommended storage range
Product has been frozen (unless specifically designed for freeze-thaw stability)
Expiration date has passed or reconstituted solution has exceeded its use-by date
Unusual odor, color change, or visible contamination

Sample Daily Schedule

As prescribed (once daily)

As prescribed by your healthcare provider injection

Site: Subcutaneous injection—rotate sites if applicable

Maintain a consistent schedule for optimal results with Gonadorelin (GnRH). Set reminders if needed. If you miss a dose, follow your healthcare provider's instructions—do not double up on doses to compensate.

Safety

Is it
safe?

Safety Profile

Gonadorelin is native GnRH and carries the safety profile established over 40+ years of clinical use in reproductive endocrinology. As the body's natural hormone, it produces minimal local side effects when dosed appropriately. The critical safety concern with gonadorelin is the initial flare effect within 24-48 hours of first dose—temporary elevation in FSH and LH—which can paradoxically suppress sex hormones before the desired stimulation occurs. This flare makes gonadorelin unsuitable for some conditions and explains why synthetic analogs (agonists, antagonists) are preferred in many modern fertility protocols.

Gonadorelin safety is supported by decades of clinical endocrinology practice and FDA approval for pituitary dysfunction (1981) with extensive post-marketing surveillance. Studies published in Fertility and Sterility and Human Reproduction show appropriate dosing produces predictable hormone responses without hepatotoxicity, nephrotoxicity, or significant cardiovascular effects. The flare phenomenon is well-characterized physiologically—not an adverse event but an expected pharmacodynamic response requiring timing consideration.

Common Side Effects

Experienced by some users

Mild headache