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Peptide Database

Goals
Fat LossMuscle BuildingInjury HealingAnti-AgingCognitive EnhancementSleep OptimizationImmune SupportGut HealingSkin RejuvenationSexual Health
Peptides
Adipotide
Weight Management
AOD-9604
Weight Management
BPC-157
Healing & Recovery
Cagrilintide
Weight Management
CJC-1295
Growth Hormone
DSIP
Sleep & Recovery
Epithalon
Anti-Aging
GHK-Cu
Anti-Aging
GHRP-2
Growth Hormone
HCG
Hormone Support
Hexarelin
Growth Hormone
HGH
Growth Hormone
IGF-1 LR3
Growth Hormone
Kisspeptin
Hormone Support
Melanotan-2
Cosmetic
MOTS-C
Metabolic
NAD+
Anti-Aging
Oxytocin Acetate
Hormone Support
PEG-MGF
Recovery
PNC-27
Cancer Research
PT-141
Sexual Health
Retatrutide
Weight Management
Selank
Cognitive
Semaglutide
Weight Management
Semax
Cognitive
Sermorelin
Growth Hormone
Snap-8
Cosmetic
SS-31
Mitochondrial
TB-500
Healing & Recovery
Tesamorelin
Growth Hormone
Thymosin Alpha-1
Immune
Tirzepatide
Weight Management
Total Peptides: 32
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Peptide Comparison

SYN-AKEvsAcetyl Hexapeptide-3 (Argireline)

Synthetic snake venom-mimetic tripeptide that competitively antagonizes nicotinic acetylcholine receptors for rapid expression wrinkle reduction.

SNARE complex inhibitor that reduces expression wrinkles through topical neuromuscular modulation — the 'Botox in a bottle' peptide.

CosmeticCosmetic

At a Glance

Quick
comparison

Dose Range

SYN-AKE

1%–4% %

Acetyl Hexapeptide-3 (Argireline)

5%–10% %

Frequency

SYN-AKE

Once daily

Acetyl Hexapeptide-3 (Argireline)

Once daily

Administration

SYN-AKE

Topical

Acetyl Hexapeptide-3 (Argireline)

Topical

Cycle Length

SYN-AKE

Ongoing/indefinite

Acetyl Hexapeptide-3 (Argireline)

Ongoing/indefinite

Onset Speed

SYN-AKE

Moderate (1-2 weeks)

Acetyl Hexapeptide-3 (Argireline)

Moderate (1-2 weeks)

Evidence Level

SYN-AKE

Limited human trials

Acetyl Hexapeptide-3 (Argireline)

Limited human trials

Efficacy

Benefit
ratings

SYN-AKE
Acetyl Hexapeptide-3 (Argireline)

Rapid Wrinkle Reduction

SYN-AKE88%
Acetyl Hexapeptide-3 (Argireline)0%

Neuromuscular Specificity

SYN-AKE90%
Acetyl Hexapeptide-3 (Argireline)0%

Multi-Target Anti-Aging

SYN-AKE82%
Acetyl Hexapeptide-3 (Argireline)0%

Expression Wrinkle Reduction

SYN-AKE0%
Acetyl Hexapeptide-3 (Argireline)85%

Non-Invasive Treatment

SYN-AKE0%
Acetyl Hexapeptide-3 (Argireline)92%

Safety Profile

SYN-AKE0%
Acetyl Hexapeptide-3 (Argireline)95%

Technical Data

Compound
specifications

SYN-AKE

Molecular Formula

C23H37N5O7

Molecular Weight

495.58 Da

Half-Life

Topical application; immediate nAChR antagonism with effects persisting up to 24 hours per application

Bioavailability

Topical dermal penetration sufficient for neuromuscular junction modulation; supplied pre-formulated in glycerin/aqua vehicle

CAS Number

823202-99-9

Acetyl Hexapeptide-3 (Argireline)

Molecular Formula

C35H62N14O11S

Molecular Weight

887.0 Da

Half-Life

Topical stability dependent on formulation; methionine residue susceptible to oxidation; stable at pH 5.5-7.7

Bioavailability

Limited skin penetration (0.22-0.54%); primarily acts at stratum corneum and superficial epidermis; O/W emulsions enhance delivery

CAS Number

616204-22-9

Applications

Best
suited for

SYN-AKE

Individuals seeking rapid-acting topical wrinkle reduction for expression lines

SYN-AKE is particularly well-suited for individuals focused on individuals seeking rapid-acting topical wrinkle reduction for expression lines. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.

Those wanting to extend or complement botulinum toxin injection results

SYN-AKE is particularly well-suited for individuals focused on those wanting to extend or complement botulinum toxin injection results. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.

People with crow's feet, forehead lines, and glabellar wrinkles from muscle movement

SYN-AKE is particularly well-suited for individuals focused on people with crow's feet, forehead lines, and glabellar wrinkles from muscle movement. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.

Users preferring a well-characterized peptide with defined receptor pharmacology

SYN-AKE is particularly well-suited for individuals focused on users preferring a well-characterized peptide with defined receptor pharmacology. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.

Acetyl Hexapeptide-3 (Argireline)

Individuals seeking non-invasive reduction of expression lines and dynamic wrinkles

Acetyl Hexapeptide-3 (Argireline) is particularly well-suited for individuals focused on individuals seeking non-invasive reduction of expression lines and dynamic wrinkles. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.

Those with needle phobia who want botulinum toxin-like effects without injections

Acetyl Hexapeptide-3 (Argireline) is particularly well-suited for individuals focused on those with needle phobia who want botulinum toxin-like effects without injections. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.

People targeting crow's feet, forehead lines, and glabellar creases

Acetyl Hexapeptide-3 (Argireline) is particularly well-suited for individuals focused on people targeting crow's feet, forehead lines, and glabellar creases. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.

Individuals looking for preventive anti-wrinkle treatment to slow expression line formation

Acetyl Hexapeptide-3 (Argireline) is particularly well-suited for individuals focused on individuals looking for preventive anti-wrinkle treatment to slow expression line formation. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.

Safety Profile

Side
effects

SYN-AKE

Common

  • Mild Tingling Sensation
  • Temporary Tightening Sensation
  • Mild Skin Dryness
  • Transient Redness

Uncommon

  • Contact Irritation (rare)

Serious

  • Allergic Reaction (not reported)
  • Anaphylactic Reaction to Snake Peptide Derivative

Acetyl Hexapeptide-3 (Argireline)

Common

  • Mild Skin Irritation
  • Transient Redness
  • Slight Dryness
  • Stinging on Compromised Skin

Uncommon

  • Contact Dermatitis

Serious

  • Allergic Contact Dermatitis

Research Status

Safety
& evidence

SYN-AKE

Evidence Level

Limited human trials

FDA Status

Research compound

Safety Overview

SYN-AKE demonstrates excellent topical tolerability with no serious adverse events reported in cosmetic use spanning 15+ years. Adverse testing including Ames test (genotoxicity) and cytotoxicity assays show negative results at therapeutic concentrations, confirming absence of mutagenic or cellular toxicity potential. Occasional mild tingling or slight dryness represents expected local skin responses rather than true adverse effects; systemic absorption is negligible due to peptide topical application mechanism.

Contraindications

  • xKnown hypersensitivity to Dipeptide Diaminobutyroyl Benzylamide Diacetate or excipients
  • xActive skin infections or significant dermatitis at intended application sites
  • xSevere compromised skin barrier in the treatment area
  • xConcurrent use with products at pH above 7.5 that may destabilize the peptide

Acetyl Hexapeptide-3 (Argireline)

Evidence Level

Limited human trials

FDA Status

Research compound

Safety Overview

Acetyl Hexapeptide-3 demonstrates an excellent safety profile for topical cosmetic use with no serious adverse events reported in clinical studies. At the 10% concentrations used in cosmetic formulations, systemic absorption is minimal and no neurotoxicity has been observed despite its mechanism of action on the neuromuscular junction. The peptide shows a safety margin of approximately 100-fold compared to toxic reference compounds. Primary concerns are limited to local skin irritation in sensitive individuals, such as mild erythema, transient stinging, or contact dermatitis in those with peptide hypersensitivity.

Contraindications

  • xKnown hypersensitivity to acetyl hexapeptide-3 or formulation components
  • xActive skin infections or open wounds at the application site
  • xNo known systemic contraindications at cosmetic concentrations
  • xUse with caution in individuals with neuromuscular disorders (theoretical concern)

Decision Guide

Which is
right for you?

Choose SYN-AKE if...

  • Individuals seeking rapid-acting topical wrinkle reduction for expression lines
  • Those wanting to extend or complement botulinum toxin injection results
  • People with crow's feet, forehead lines, and glabellar wrinkles from muscle movement
  • Users preferring a well-characterized peptide with defined receptor pharmacology

Choose Acetyl Hexapeptide-3 (Argireline) if...

  • Individuals seeking non-invasive reduction of expression lines and dynamic wrinkles
  • Those with needle phobia who want botulinum toxin-like effects without injections
  • People targeting crow's feet, forehead lines, and glabellar creases
  • Individuals looking for preventive anti-wrinkle treatment to slow expression line formation