Peptide Comparison
N-Acetyl SelankvsSelank
Acetylated tuftsin analogue heptapeptide with enhanced stability and anxiolytic, nootropic, and immunomodulatory properties acting through GABAergic modulation and BDNF upregulation
A clever brain-boosting peptide derived from your immune system's natural tuftsin molecule—it calms anxiety and sharpens your mind without the drowsiness or addiction risks of traditional anti-anxiety medications.
At a Glance
Quick
comparison
Dose Range
N-Acetyl Selank
0.15–0.5 mg
Selank
250–500 mcg
Frequency
N-Acetyl Selank
Once daily
Selank
Once daily
Administration
N-Acetyl Selank
Intranasal spray
Selank
Intranasal
Cycle Length
N-Acetyl Selank
4-6 weeks
Selank
4-6 weeks
Onset Speed
N-Acetyl Selank
Rapid (hours to days)
Selank
Rapid (hours to days)
Evidence Level
N-Acetyl Selank
Limited human trials
Selank
Limited human trials
Efficacy
Benefit
ratings
Cognitive
Anxiety Relief
Cognitive Enhancement
Immune Support
Technical Data
Compound
specifications
N-Acetyl Selank
Molecular Formula
C35H59N11O10
Molecular Weight
793.9 g/mol
Half-Life
Extended compared to native Selank (~7-10 min plasma half-life); exact half-life of N-Acetyl form not published but estimated 2-3x longer
Bioavailability
Enhanced intranasal and subcutaneous bioavailability compared to native Selank due to N-acetylation protecting against aminopeptidase degradation
CAS Number
Not assigned (N-Acetyl Selank); 129954-34-3 (parent Selank)
Selank
Molecular Formula
C33H57N11O9
Molecular Weight
751.9 g/mol
Half-Life
2-3 minutes (plasma); effects last hours due to downstream signaling
Bioavailability
High intranasal absorption; near 100% subcutaneous
CAS Number
129954-34-3
Protocols
Dosing
tiers
N-Acetyl Selank
Selank
Applications
Best
suited for
N-Acetyl Selank
Anxiolytic support without the sedation, tolerance, or dependence associated with benzodiazepines
N-Acetyl Selank is particularly well-suited for individuals focused on anxiolytic support without the sedation, tolerance, or dependence associated with benzodiazepines. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Cognitive enhancement through BDNF-mediated neuroplasticity
N-Acetyl Selank is particularly well-suited for individuals focused on cognitive enhancement through bdnf-mediated neuroplasticity. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Stress resilience and emotional regulation in high-demand environments
N-Acetyl Selank is particularly well-suited for individuals focused on stress resilience and emotional regulation in high-demand environments. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Complementary nootropic in cognitive stacks targeting multiple neurotransmitter systems
N-Acetyl Selank is particularly well-suited for individuals focused on complementary nootropic in cognitive stacks targeting multiple neurotransmitter systems. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Selank
Anxiety Without the Fog
If traditional anti-anxiety medications leave you feeling sedated, foggy, or 'not yourself,' Selank offers a refreshing alternative. It calms anxious thoughts while keeping your mind sharp—like turning down the volume on worry without muting your brain.
Cognitive Performers
Students, professionals, and anyone facing demanding mental tasks love Selank for its dual action. It simultaneously reduces performance anxiety while enhancing memory and focus—the best of both worlds when you need to think clearly under pressure.
Stress Resilience Seekers
Chronic stress wreaks havoc on your brain. Selank helps protect against stress-induced cognitive decline by supporting BDNF levels and modulating your stress response. Think of it as building a buffer between you and life's daily pressures.
Natural Approach Enthusiasts
Derived from tuftsin—a natural peptide your own immune system produces—Selank appeals to those seeking more 'natural' solutions. It works with your body's existing systems rather than overriding them like synthetic drugs.
Safety Profile
Side
effects
N-Acetyl Selank
Common
- Nasal irritation
- Transient headache
- Mild drowsiness or fatigue
- Vivid dreams
- Appetite changes
Uncommon
- Nasal congestion or epistaxis
Serious
- Allergic reaction
Selank
Common
- Nasal irritation
- Mild fatigue
- Mild headache
- Injection site redness
Uncommon
- Vivid dreams
- Dizziness
Serious
- Allergic reaction
Research Status
Safety
& evidence
N-Acetyl Selank
Evidence Level
Limited human trials
FDA Status
Research compound
Safety Overview
N-Acetyl Selank demonstrates favorable safety in preclinical and clinical research with no serious adverse events at therapeutic doses. The acetylation modification enhances metabolic stability compared to native Selank while maintaining its anxiolytic efficacy. Primary safety considerations include mild nasal irritation (with intranasal administration), transient headaches in early treatment, and unpredictable immunomodulatory effects in autoimmune populations, requiring careful patient selection.
Contraindications
- xKnown hypersensitivity to Selank, tuftsin, or any component of the formulation
- xPregnancy and breastfeeding — insufficient safety data
- xActive autoimmune disorders — immunomodulatory effects may be unpredictable
- xConcurrent use of immunosuppressive therapy — potential for immune system interference
Selank
Evidence Level
Limited human trials
FDA Status
Research compound
Safety Overview
Selank has demonstrated a favorable safety profile across multiple Russian clinical studies spanning over two decades. In human trials comparing Selank to traditional anxiolytics like phenazepam, Selank showed comparable anti-anxiety effects with significantly better tolerability and no sedation, dependence, or memory impairment. The peptide has been approved for clinical use in Russia since the 1990s for anxiety and neurasthenia.
Contraindications
- xPregnancy or planning to become pregnant
- xCurrently breastfeeding
- xKnown allergy to peptide components
- xChildren and adolescents
- xSevere psychiatric disorders requiring immediate intervention
Decision Guide
Which is
right for you?
Choose N-Acetyl Selank if...
- Anxiolytic support without the sedation, tolerance, or dependence associated with benzodiazepines
- Cognitive enhancement through BDNF-mediated neuroplasticity
- Stress resilience and emotional regulation in high-demand environments
- Complementary nootropic in cognitive stacks targeting multiple neurotransmitter systems
Choose Selank if...
- Anxiety relief without sedation
- Cognitive enhancement and focus
- Memory improvement
- Stress resilience