Peptide Comparison
LeuphasylvsAcetyl Hexapeptide-3 (Argireline)
Enkephalin-mimetic pentapeptide that reduces expression wrinkles through presynaptic neuromuscular inhibition, synergizing with Argireline.
SNARE complex inhibitor that reduces expression wrinkles through topical neuromuscular modulation — the 'Botox in a bottle' peptide.
At a Glance
Quick
comparison
Dose Range
Leuphasyl
2%–5% %
Acetyl Hexapeptide-3 (Argireline)
5%–10% %
Frequency
Leuphasyl
Once daily
Acetyl Hexapeptide-3 (Argireline)
Once daily
Administration
Leuphasyl
Topical
Acetyl Hexapeptide-3 (Argireline)
Topical
Cycle Length
Leuphasyl
Ongoing/indefinite
Acetyl Hexapeptide-3 (Argireline)
Ongoing/indefinite
Onset Speed
Leuphasyl
Moderate (1-2 weeks)
Acetyl Hexapeptide-3 (Argireline)
Moderate (1-2 weeks)
Evidence Level
Leuphasyl
Limited human trials
Acetyl Hexapeptide-3 (Argireline)
Limited human trials
Efficacy
Benefit
ratings
Expression Wrinkle Reduction
Peptide Synergy
Safety & Tolerability
Non-Invasive Treatment
Safety Profile
Technical Data
Compound
specifications
Leuphasyl
Molecular Formula
C29H39N5O7
Molecular Weight
569.65 Da
Half-Life
Topical application; sustained neuromuscular effect with twice-daily reapplication
Bioavailability
Topical dermal penetration sufficient for neuromuscular junction modulation in facial skin
CAS Number
64963-01-5
Acetyl Hexapeptide-3 (Argireline)
Molecular Formula
C35H62N14O11S
Molecular Weight
887.0 Da
Half-Life
Topical stability dependent on formulation; methionine residue susceptible to oxidation; stable at pH 5.5-7.7
Bioavailability
Limited skin penetration (0.22-0.54%); primarily acts at stratum corneum and superficial epidermis; O/W emulsions enhance delivery
CAS Number
616204-22-9
Applications
Best
suited for
Leuphasyl
Individuals seeking non-invasive alternatives to botulinum toxin for expression lines
Leuphasyl is particularly well-suited for individuals focused on individuals seeking non-invasive alternatives to botulinum toxin for expression lines. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Those wanting to enhance Argireline results through complementary peptide mechanisms
Leuphasyl is particularly well-suited for individuals focused on those wanting to enhance argireline results through complementary peptide mechanisms. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
People with dynamic wrinkles on the forehead, glabella, and crow's feet areas
Leuphasyl is particularly well-suited for individuals focused on people with dynamic wrinkles on the forehead, glabella, and crow's feet areas. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Users preferring gentle peptide-based wrinkle treatments for sensitive skin
Leuphasyl is particularly well-suited for individuals focused on users preferring gentle peptide-based wrinkle treatments for sensitive skin. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Acetyl Hexapeptide-3 (Argireline)
Individuals seeking non-invasive reduction of expression lines and dynamic wrinkles
Acetyl Hexapeptide-3 (Argireline) is particularly well-suited for individuals focused on individuals seeking non-invasive reduction of expression lines and dynamic wrinkles. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Those with needle phobia who want botulinum toxin-like effects without injections
Acetyl Hexapeptide-3 (Argireline) is particularly well-suited for individuals focused on those with needle phobia who want botulinum toxin-like effects without injections. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
People targeting crow's feet, forehead lines, and glabellar creases
Acetyl Hexapeptide-3 (Argireline) is particularly well-suited for individuals focused on people targeting crow's feet, forehead lines, and glabellar creases. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Individuals looking for preventive anti-wrinkle treatment to slow expression line formation
Acetyl Hexapeptide-3 (Argireline) is particularly well-suited for individuals focused on individuals looking for preventive anti-wrinkle treatment to slow expression line formation. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Safety Profile
Side
effects
Leuphasyl
Common
- Transient Product Sensation
- Initial Adjustment Period
- Dryness from Vehicle
- Reduced Effect Over Time
Uncommon
- Contact Sensitivity (very rare)
Serious
- Allergic Reaction (theoretical)
- Opioid Receptor Cross-Reactivity
Acetyl Hexapeptide-3 (Argireline)
Common
- Mild Skin Irritation
- Transient Redness
- Slight Dryness
- Stinging on Compromised Skin
Uncommon
- Contact Dermatitis
Serious
- Allergic Contact Dermatitis
Research Status
Safety
& evidence
Leuphasyl
Evidence Level
Limited human trials
FDA Status
Research compound
Safety Overview
Leuphasyl (a pentapeptide GnRH agonist) carries the safety profile of the GnRH agonist drug class with 40+ years of veterinary and research use. Inherent to all GnRH agonists is the initial flare effect (24-72 hours of elevated FSH/LH before suppression), which can cause transient behavioral changes in animals and temporary follicle overgrowth in reproductive applications. Injection site reactions and possible initial inflammation are common but resolve within days. The compound shows no genotoxicity, hepatotoxicity, or renal toxicity in preclinical evaluations.
Contraindications
- xKnown hypersensitivity to Pentapeptide-18 or formulation components
- xActive dermatitis or skin infections at intended application sites
- xConcurrent use with topical products at extreme pH that may hydrolyze the peptide
- xSevere skin barrier compromise in the treatment area
Acetyl Hexapeptide-3 (Argireline)
Evidence Level
Limited human trials
FDA Status
Research compound
Safety Overview
Acetyl Hexapeptide-3 demonstrates an excellent safety profile for topical cosmetic use with no serious adverse events reported in clinical studies. At the 10% concentrations used in cosmetic formulations, systemic absorption is minimal and no neurotoxicity has been observed despite its mechanism of action on the neuromuscular junction. The peptide shows a safety margin of approximately 100-fold compared to toxic reference compounds. Primary concerns are limited to local skin irritation in sensitive individuals, such as mild erythema, transient stinging, or contact dermatitis in those with peptide hypersensitivity.
Contraindications
- xKnown hypersensitivity to acetyl hexapeptide-3 or formulation components
- xActive skin infections or open wounds at the application site
- xNo known systemic contraindications at cosmetic concentrations
- xUse with caution in individuals with neuromuscular disorders (theoretical concern)
Decision Guide
Which is
right for you?
Choose Leuphasyl if...
- Individuals seeking non-invasive alternatives to botulinum toxin for expression lines
- Those wanting to enhance Argireline results through complementary peptide mechanisms
- People with dynamic wrinkles on the forehead, glabella, and crow's feet areas
- Users preferring gentle peptide-based wrinkle treatments for sensitive skin
Choose Acetyl Hexapeptide-3 (Argireline) if...
- Individuals seeking non-invasive reduction of expression lines and dynamic wrinkles
- Those with needle phobia who want botulinum toxin-like effects without injections
- People targeting crow's feet, forehead lines, and glabellar creases
- Individuals looking for preventive anti-wrinkle treatment to slow expression line formation