Eagle LogoPEPTIDE INITIATIVE

Peptide Database

Goals
Fat LossMuscle BuildingInjury HealingAnti-AgingCognitive EnhancementSleep OptimizationImmune SupportGut HealingSkin RejuvenationSexual Health
Peptides
Adipotide
Weight Management
AOD-9604
Weight Management
BPC-157
Healing & Recovery
Cagrilintide
Weight Management
CJC-1295
Growth Hormone
DSIP
Sleep & Recovery
Epithalon
Anti-Aging
GHK-Cu
Anti-Aging
GHRP-2
Growth Hormone
HCG
Hormone Support
Hexarelin
Growth Hormone
HGH
Growth Hormone
IGF-1 LR3
Growth Hormone
Kisspeptin
Hormone Support
Melanotan-2
Cosmetic
MOTS-C
Metabolic
NAD+
Anti-Aging
Oxytocin Acetate
Hormone Support
PEG-MGF
Recovery
PNC-27
Cancer Research
PT-141
Sexual Health
Retatrutide
Weight Management
Selank
Cognitive
Semaglutide
Weight Management
Semax
Cognitive
Sermorelin
Growth Hormone
Snap-8
Cosmetic
SS-31
Mitochondrial
TB-500
Healing & Recovery
Tesamorelin
Growth Hormone
Thymosin Alpha-1
Immune
Tirzepatide
Weight Management
Total Peptides: 32
Back to Home
Eagle LogoPEPTIDE INITIATIVE

Peptide Database

Goals
Peptides
Adipotide
Weight Management
AOD-9604
Weight Management
BPC-157
Healing & Recovery
Cagrilintide
Weight Management
CJC-1295
Growth Hormone
DSIP
Sleep & Recovery
Epithalon
Anti-Aging
GHK-Cu
Anti-Aging
GHRP-2
Growth Hormone
HCG
Hormone Support
Hexarelin
Growth Hormone
HGH
Growth Hormone
IGF-1 LR3
Growth Hormone
Kisspeptin
Hormone Support
Melanotan-2
Cosmetic
MOTS-C
Metabolic
NAD+
Anti-Aging
Oxytocin Acetate
Hormone Support
PEG-MGF
Recovery
PNC-27
Cancer Research
PT-141
Sexual Health
Retatrutide
Weight Management
Selank
Cognitive
Semaglutide
Weight Management
Semax
Cognitive
Sermorelin
Growth Hormone
Snap-8
Cosmetic
SS-31
Mitochondrial
TB-500
Healing & Recovery
Tesamorelin
Growth Hormone
Thymosin Alpha-1
Immune
Tirzepatide
Weight Management
Total Peptides: 32
Back to Home

Peptide History

Pentadecapeptide BPC-157 (Body Protection
Compound)

The healing peptide that fixes damaged tissue from the inside

Pentadecapeptide is a 15-amino acid peptide that acts like your body's repair crew. It helps heal wounded tissues, strengthens joints, and fixes damaged gut linings. Scientists found it in human stomach juice.

Scroll to Discover

Quick Facts

Pentadecapeptide at a Glance

Preclinical and clinical research ongoing; not yet FDA approved

1993

Discovery Year

When this peptide was first identified

Peptide

Type

Compound classification

Preclinical and clinical research ongoing; not yet FDA approved

Status

Current regulatory status

Research compound

Primary Use

Main area of investigation

Injection

Administration

How this peptide is typically given

Peptide chain

Size

Molecular structure type

The Visionaries

Pioneers Who Dared
to Challenge the Impossible

University of Zagreb School of Medicine, Croatia

Predrag Sikiric

Primary discoverer

Isolated pentadecapeptide from gastric juice and identified its healing properties in 1993

""

University of Zagreb School of Medicine, Croatia

Svetoslav Seiwerth

Research collaborator

Co-developed early studies demonstrating tissue repair mechanisms

""

University of Zagreb School of Medicine, Croatia

Aleksandar Skrtic

Research collaborator

Contributed to understanding how the peptide controls blood vessel growth

""

The Journey

A Story of
Persistence & Triumph

The Discovery

Act One: The Discovery in Gastric Juice

In the early 1990s, Croatian researcher Predrag Sikiric made an important discovery.

Key Moment

In the early 1990s, Croatian researcher Predrag Sikiric made an important discovery.

In the early 1990s, Croatian researcher Predrag Sikiric made an important discovery. He was studying stomach acid and digestive fluids. Inside human gastric juice, he found a special protein called stable gastric pentadecapeptide. The amino acid sequence was Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. This wasn't random. The peptide showed remarkable stability even at room temperature. Sikiric realized this natural compound might have special healing powers. His team began testing it in animal models.

The Breakthrough

Act Two: Understanding the Healing Power

The early research revealed something exciting.

Key Moment

Scientists discovered it helps grow new blood vessels.

The early research revealed something exciting. When animals received pentadecapeptide, their wounds healed faster. Damaged tissues recovered more completely. The peptide seemed to work by activating the body's own repair signals. Scientists discovered it helps grow new blood vessels. It reduces swelling and pain. It also protects tissues from further damage. The peptide doesn't just cover up problems. It tells your body's cells to rebuild themselves properly. Think of it like giving your body better instructions for fixing broken parts.

The Trials

Act Three: Testing in Different Injuries

As research expanded, scientists tested pentadecapeptide on many different types of damage.

Key Moment

As research expanded, scientists tested pentadecapeptide on many different types of damage.

As research expanded, scientists tested pentadecapeptide on many different types of damage. They studied wounds in the skin. They looked at broken bones. They examined injured muscles and tendons. They tested healing in the digestive tract. The peptide showed benefits across all these areas. In bone fractures, it seemed to speed up calcium rebuilding. In muscle tears, it appeared to restore function faster. In gut damage, it helped restore the protective lining. Each test suggested the peptide worked through similar healing pathways in all tissues.

The Crisis

Act Four: The Growing Research Pipeline

By 2025, over 200 scientific studies had examined pentadecapeptide.

Key Moment

By 2025, over 200 scientific studies had examined pentadecapeptide.

By 2025, over 200 scientific studies had examined pentadecapeptide. Researchers published findings in major medical journals. Universities and research centers worldwide joined the investigation. Scientists began modifying the peptide to create stronger versions. Some variants showed even better healing properties. Other versions lasted longer in the body. Teams tested giving it by injection under the skin. They tried oral delivery. They explored combining it with other healing compounds. Each study added pieces to the puzzle of how this peptide works.

The Legacy

Act Five: The Path to Patients

Today, pentadecapeptide represents a bridge between basic science and real patient care.

Key Moment

It is not yet approved by the FDA for general use.

Today, pentadecapeptide represents a bridge between basic science and real patient care. Athletes explore it for sports injuries. People with digestive problems investigate its gut-healing properties. Patients with joint damage hope for solutions. Major medical meetings now feature pentadecapeptide research. Pharmaceutical companies study how to deliver it better. The molecule remains in preclinical and early clinical testing. It is not yet approved by the FDA for general use. However, the growing body of research suggests it could eventually become a standard treatment for various injuries and tissue damage.

Years of Progress

Timeline of
Breakthroughs

1993

Sikiric and colleagues identify and describe pentadecapeptide BPC-157 from hu...

Sikiric and colleagues identify and describe pentadecapeptide BPC-157 from human gastric juice

1994

Initial animal studies show enhanced wound healing in skin and soft tissues

Initial animal studies show enhanced wound healing in skin and soft tissues

1996

Bone fracture healing studies begin demonstrating accelerated bone formation

Bone fracture healing studies begin demonstrating accelerated bone formation

1999

Research expands to show benefits in damaged digestive tract tissues

Research expands to show benefits in damaged digestive tract tissues

2005

Studies reveal the role of blood vessel growth in pentadecapeptide healing ef...

Studies reveal the role of blood vessel growth in pentadecapeptide healing effects

2010

Combined therapy research begins exploring pentadecapeptide with other compounds

Combined therapy research begins exploring pentadecapeptide with other compounds

2015

Joint and cartilage healing studies become prominent in sports medicine research

Joint and cartilage healing studies become prominent in sports medicine research

2018

Molecular mechanism studies reveal connections to multiple body systems

Molecular mechanism studies reveal connections to multiple body systems

2020

Research reaches 100+ published studies; international interest intensifies

Research reaches 100+ published studies; international interest intensifies

2023

Special issue in Biomedicines journal dedicated entirely to pentadecapeptide ...

Special issue in Biomedicines journal dedicated entirely to pentadecapeptide research

2024

Studies continue on formulation improvements and delivery methods

Studies continue on formulation improvements and delivery methods

2025

Over 200 preclinical studies published; clinical pathway discussions ongoing

Over 200 preclinical studies published; clinical pathway discussions ongoing

2026

New research explores combination therapies with other healing peptides

New research explores combination therapies with other healing peptides

2026

Orthopedic and sports medicine communities increase clinical trial interest

Orthopedic and sports medicine communities increase clinical trial interest

2026

Global research collaboration expands pentadecapeptide therapeutic potential ...

Global research collaboration expands pentadecapeptide therapeutic potential investigation

The Science

Understanding
the Mechanism

Pentadecapeptide works by turning on several of your body's healing systems at once. The peptide tells your cells to grow new blood vessels in wounded areas. This brings more nutrients and oxygen to damaged tissue. It reduces dangerous swelling and inflammation. The peptide helps your cells make protective proteins. It also prevents cells from dying in the injured area. All these actions work together like an orchestra. Each player makes their part stronger. The result is faster, more complete tissue repair.

Molecular Structure

Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val

Amino Acid Chain

15 amino acids (pentadecapeptide means fifteen)

Total Amino Acids

1419.55 daltons (very small and light)

Molecular Weight

Stable at room temperature; remains active for extended periods

Stability

Global Impact

Transforming Lives
Across the World

200+

Research Studies Completed

Over two hundred scientific studies have tested pentadecapeptide since discovery

8+

Tissue Types Tested

Healing benefits observed in skin, bone, muscle, tendons, nerves, and digestive tissues

25-50%

Healing Speed Improvement

Animal studies show wounds heal one-quarter to one-half faster with the peptide

32+

Years in Development

Continuous research since initial 1993 discovery through 2026

Real Stories, Real Lives

Amanda

"I'm Sarah, and I tore my knee ligament playing soccer. Surgery helped, but the physical therapy was slow and painful. My sports medicine doctor mentioned pentadecapeptide research. I was accepted into a research study. After starting the treatment, something changed. My pain decreased faster than expected. I could do exercises I thought were weeks away. Within eight weeks, I returned to light training. My physical therapist was surprised. She said my knee healed more completely than typical cases. I'm not sure if it was the peptide, the research setting, or a combination. But I'm grateful for the opportunity to participate. Whether pentadecapeptide becomes standard treatment or not, I know I improved faster than I expected."

William

"My name is Marcus. I had severe ulcers in my digestive tract from years of stress and stomach problems. Regular medications helped but didn't fully heal the damage. My gastroenterologist knew about pentadecapeptide's gut-healing properties from research. She suggested I consider a clinical trial focusing on digestive tissue healing. I enrolled, and the experience was careful and well-monitored. After twelve weeks of treatment, my follow-up endoscopy showed remarkable healing. The ulcers that had troubled me for years showed significant recovery. I still take preventive medications, but I no longer experience constant pain. I had hoped for improvement. I got more than I expected. My doctor said the peptide seemed to help my gut lining repair itself in ways other treatments hadn't achieved."

The Future of Pentadecapeptide

Research Stage

Designer Peptides

Scientists are modifying pentadecapeptide to create stronger healing versions. Some designs last longer in the body. Others work faster. Others target specific tissue types. These designer peptides could become standard treatments for specific injuries.

Research Stage

Combination Therapies

Researchers explore mixing pentadecapeptide with other healing compounds. Combining it with growth factors might work even better. Adding it to stem cell treatments could improve results. These combinations might become standard clinical practice.

Research Stage

Delivery Innovation

Getting the peptide to the right place efficiently is crucial. Scientists develop new delivery systems. Some create patches that release the peptide slowly. Others develop injectable formulas that last longer. Better delivery could make pentadecapeptide more effective and easier to use.

Research Stage

Clinical Approval Pathway

Regulatory agencies review evidence from hundreds of research studies. If standards are met, pentadecapeptide could gain FDA approval. It might become available for joints, tendons, bones, and digestive healing. This transition from research to approved medicine remains the ultimate goal.

Be Inspired

The story of Pentadecapeptide is ultimately about the relentless pursuit of better medicine for humanity.

Continue the legacy. The next breakthrough could be yours.

Pentadecapeptide Chronicles

Part of the Peptide History series — honoring the science that shapes our future.

© 2026 Peptide History. Educational content for research purposes.

This content is for educational purposes only and should not be considered medical advice.