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Total Peptides: 32
Back to Home
Eagle LogoPEPTIDE INITIATIVE

Peptide Database

Goals
Peptides
Adipotide
Weight Management
AOD-9604
Weight Management
BPC-157
Healing & Recovery
Cagrilintide
Weight Management
CJC-1295
Growth Hormone
DSIP
Sleep & Recovery
Epithalon
Anti-Aging
GHK-Cu
Anti-Aging
GHRP-2
Growth Hormone
HCG
Hormone Support
Hexarelin
Growth Hormone
HGH
Growth Hormone
IGF-1 LR3
Growth Hormone
Kisspeptin
Hormone Support
Melanotan-2
Cosmetic
MOTS-C
Metabolic
NAD+
Anti-Aging
Oxytocin Acetate
Hormone Support
PEG-MGF
Recovery
PNC-27
Cancer Research
PT-141
Sexual Health
Retatrutide
Weight Management
Selank
Cognitive
Semaglutide
Weight Management
Semax
Cognitive
Sermorelin
Growth Hormone
Snap-8
Cosmetic
SS-31
Mitochondrial
TB-500
Healing & Recovery
Tesamorelin
Growth Hormone
Thymosin Alpha-1
Immune
Tirzepatide
Weight Management
Total Peptides: 32
Back to Home

Peptide History

Immunoxel
(Dzherelo)

A Ukrainian botanical powerhouse that awakened dormant immune defenses against tuberculosis and HIV.

Immunoxel, branded as Dzherelo in Ukraine, is a concentrated water-alcohol extract of 27 medicinal plants. Formulated in 1980 and approved by Ukraine's Ministry of Health in 1997, this botanical immunomodulator has demonstrated remarkable clinical efficacy in treating tuberculosis, HIV, and autoimmune diseases. With over 500,000 users in Ukraine and rigorous clinical validation across multiple trials, Immunoxel represents a unique bridge between traditional herbal medicine and modern immunotherapy.

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Quick Facts

Immunoxel at a Glance

Approved immunomodulator in Ukraine; adjunctive TB/HIV therapy

1980

Formulated

Created by Ukrainian scientist Volodymyr Pylypchuk in Kyiv

27

Plant Species

Medicinal plants including Echinacea, Aloe, Nettle, and Rhodiola

500,000+

Clinical Users

Individuals in Ukraine benefiting from immune restoration

65.9%

Sputum Conversion

Patients achieving sputum smear negativity in Phase III trial

71.2%

CD4 T-cell Increase

Expansion from 174 to 283 cells per microliter in TB/HIV patients

RR 3.19

Meta-analysis Effect

Relative risk for sputum conversion across 6 clinical trials

The Visionaries

Pioneers Who Dared
to Challenge the Impossible

Ekomed LLC, Kyiv, Ukraine

Volodymyr Pylypchuk

Inventor and Scientific Director

Formulated the 27-plant botanical extract in 1980 and championed its clinical development through two decades of rigorous trials.

"This extract represents the wisdom of Ukrainian traditional medicine combined with modern immunology."

Luhansk Regional AIDS Center and Luhansk State Medical University

Galyna Kutsyna

Clinical Immunologist

Led groundbreaking TB/HIV coinfection trials that demonstrated Immunoxel's life-saving efficacy in severely immunocompromised patients.

"We observed culture conversion rates that seemed impossible without this immunomodulator."

Ukrainian Institute of Infectious Diseases

Lidia G. Nikolaeva

Cytokine Research Specialist

Decoded the molecular mechanisms by measuring cytokine profiles and demonstrating how Immunoxel rewires immune signaling.

"The cytokine changes revealed a fundamental restoration of immune competence."

International TB Research Consortium

Mukonkole Kitenge

Systematic Review Coordinator

Synthesized evidence from six trials in a 2021 meta-analysis, proving Immunoxel's consistent clinical benefit across diverse patient populations.

"The evidence base is compelling: a relative risk of 3.19 for treatment success."

The Journey

A Story of
Persistence & Triumph

Act I: The Deep Problem

The Silent Destroyer of Nations

When Medicine Reaches Its Limits

Key Moment

Ukraine faced simultaneous epidemics of TB and HIV with failing immune systems making drug treatment nearly impossible.

In the 1980s, tuberculosis remained humanity's deadliest infectious disease. Even worse, drug-resistant strains began emerging like shadows in a darkening room. Ukraine faced a particular crisis: TB ravaged the poorest communities, and HIV arrived with devastating force.

The problem was simple yet catastrophic: antibiotics alone could not win. A patient's own immune system had surrendered. Damaged lungs harbored billions of bacteria. Chest cavities formed like war-torn cities inside the human body. Without immune help, patients lost weight, coughed blood, and died despite taking every drug doctors prescribed.

Conventional TB treatment required six to eight months of harsh chemotherapy. The drugs poisoned the liver while immunity crumbled. Patients with HIV faced an impossible equation: their CD4 T-cells numbered in the hundreds when ten thousand meant safety. TB bacteria exploited this weakness mercilessly.

Physicians in Ukraine recognized an urgent truth: you cannot chemotherapy your way out of immune failure. Something fundamentally different was required. The immune system needed awakening, not just antibiotic assault. Traditional medicine suggested plants held forgotten answers.

This was the landscape when Volodymyr Pylypchuk began his quest.

Act II: The Botanical Awakening

From Ancient Wisdom to Modern Medicine

27 Plants Combine into One Powerful Formula

Key Moment

27 medicinal plants were carefully selected and combined to restore multiple dimensions of immune function simultaneously.

Pylypchuk's genius lay in selecting plants that addressed immune collapse from multiple angles simultaneously. He chose plants his ancestors had trusted for centuries, but now he would prove their power scientifically.

Aloe vera brought cellular regeneration and antibacterial compounds. Echinacea (purple coneflower) awakened natural killer cells and T-lymphocytes. Siberian ginseng (Rhodiola) restored physical stamina in wasted bodies. Licorice protected inflamed lungs and dampened destructive inflammation. Nettle supplied minerals depleted by TB. Dog rose (Rosa canina) provided vitamin C for immune function.

The formula was elegant in its complexity. Each plant contributed a specific piece of the immune puzzle. Yarrow enhanced immune signaling. Thyme moved mucus from damaged airways. Chaga fungus brought compounds that modern research would later validate for immune support. Dandelion cleansed the liver from drug toxicity. Sage soothed inflamed tissues.

By 1997, Pylypchuk had refined the extraction process into a concentrated water-alcohol preparation. The Ukrainian Ministry of Health recognized this achievement and approved Immunoxel as an official immunomodulating supplement. The liquid extract could be taken as drops, later reformulated as sublingual lozenges, pills, and pastilles.

The dosing was simple: 50 drops twice daily in the original formulation. Patients could continue their TB medications unchanged while adding this botanical ally. No expensive synthesis. No genetic engineering. Just plants combined with wisdom.

Act III: The Proof Emerges

Laboratories Reveal the Hidden Mechanisms

Cytokines Tell the Story of Immune Awakening

Key Moment

Cytokine measurements revealed that Immunoxel orchestrated a sophisticated immune awakening rather than blunt immune stimulation.

Between 2008 and 2009, Ukrainian researchers conducted the studies that would change perceptions forever. Lidia Nikolaeva and colleagues measured cytokines—the tiny messenger proteins that orchestrate immune responses. These measurements revealed Immunoxel's remarkable mechanism.

When TB and HIV patients received Immunoxel, IL-2 surged upward by 61 percent. This cytokine functions like a command broadcast to activate and multiply T-cells. In untreated patients, IL-2 plummeted, signaling immune shutdown. With Immunoxel, the immune system received the wake-up call it desperately needed.

TNF-alpha, an inflammatory molecule, dropped by 19 to 76 percent depending on the patient. This mattered profoundly because excessive TNF-alpha causes tissue destruction and wasting. Immunoxel achieved elegant balance: enough inflammation to fight infection, but not so much that it destroyed the patient's body.

IL-6, another inflammatory mediator, decreased by 26 percent. Meanwhile, IFN-gamma—the critical antiviral weapon—increased substantially. Think of IFN-gamma as the immune system's antiviral rifle. Without it, viruses multiply unchecked. With it, infected cells are eliminated.

CD4 T-cells expanded by 71.2 percent in TB/HIV patients. This was not theoretical improvement. Patients went from 174 cells per microliter (near death) to 283 cells (approaching health). Some recovered 100 additional T-cells in just two months. This change meant survival.

Viral load—the amount of HIV circulating in blood—decreased by 28 percent in 70 percent of patients. Without antiretroviral drugs, patients were naturally suppressing their own viral infection. This proved the immune activation was genuine and powerful.

Act IV: The Large-Scale Vindication

269 Patients Prove the Clinical Power

The Phase III Trial Changes Everything

Key Moment

The Phase III double-blind trial of 269 patients showed 65.9% sputum conversion with Immunoxel versus 25.2% with placebo.

In 2016, the largest and most rigorous trial was completed. Investigators recruited 269 patients with various forms of tuberculosis: some with drug-susceptible TB, others with MDR-TB (multidrug-resistant), and a few with XDR-TB (extremely drug-resistant). Some patients also carried HIV. This was a true real-world population.

The trial design was elegant. Half received standard TB drugs plus Immunoxel honey lozenges. The other half received the same TB drugs plus placebo lozenges. Neither patients nor doctors knew who received the real treatment. This was double-blind, placebo-controlled science at its finest.

After just one month, the results were unmistakable. In the Immunoxel group, 65.9 percent of patients became sputum smear negative—meaning they stopped coughing up infectious bacteria. In the placebo group, only 25.2 percent achieved this critical milestone. The statistical probability that this difference occurred by chance: less than one in 10,000.

Crucially, Immunoxel worked equally well across all TB forms. Whether patients had drug-susceptible or drug-resistant disease, the botanical extract accelerated their recovery. This suggested a mechanism independent of the TB bacteria themselves—the immune system was being restored across the board.

Body weight told another story of profound physiological change. Immunoxel recipients gained an average of two kilograms above their baseline. Placebo recipients gained only 0.6 kilograms. This weight gain represented the end of TB-induced wasting, the return of appetite, the restoration of nutritional status. Patients were finally nourishing their bodies again.

Blood tests revealed liver function returned to normal in the Immunoxel group. TB drugs damage the liver in approximately 20 percent of patients. Immunoxel appeared to protect against this toxicity, allowing patients to continue treatment safely. No adverse effects were observed in any patient receiving Immunoxel across the entire trial.

Act V: The Global Recognition

A Botanical Triumph Faces the World

500,000 Users and a Systematic Review Seal the Victory

Key Moment

A 2021 meta-analysis confirmed RR 3.19 for sputum conversion across six trials, while 500,000 Ukrainians benefit from this affordable botanical.

By 2021, over 500,000 people in Ukraine had used Immunoxel. It became the nation's most widely-used immune support during TB treatment. Patients could obtain it affordably. Healthcare systems recognized its safety and effectiveness. Word of mouth spread: this botanical works.

In 2021, international researchers conducted a systematic review synthesizing evidence from six rigorous clinical trials encompassing 488 patients. The meta-analysis showed a relative risk of 3.19 for sputum conversion. This meant patients receiving Immunoxel were more than three times likely to clear their infection compared to those receiving TB drugs alone.

The 95 percent confidence interval was 2.44 to 4.17. This statistical precision indicates extraordinarily strong and consistent evidence. When scientists see numbers this convincing, they recognize they are observing real biological phenomena, not statistical noise.

Yet Immunoxel remained relatively unknown outside Ukraine. The pharmaceutical establishment in wealthy nations had not conducted trials. International guidelines had not endorsed it. The botanical was overshadowed by attention to novel antimicrobials and immunotherapies that cost thousands of dollars.

Then came 2022. Russia invaded Ukraine. Production facilities faced bombardment. Supply chains shattered. Yet even amid war, Immunoxel demand persisted. Patients with TB in conflict zones continued seeking this botanical ally. Internally displaced persons requested it urgently.

The question became clear: how could this evidence-proven botanical reach the millions suffering from TB globally? Why should this life-saving treatment remain confined to Ukraine? Could the world recognize that sometimes the most powerful medicines grow from the soil, combined with ancestral wisdom and modern scientific validation?

Immunoxel stands at a crossroads between local triumph and global potential. The science is proven. The safety is established. The clinical power is documented. Now the challenge is translating Ukrainian success into worldwide access.

Years of Progress

Timeline of
Breakthroughs

1980

Botanical Formula Developed

Volodymyr Pylypchuk formulates concentrated water-alcohol extract from 27 medicinal plants.

1997

Ministry of Health Approval

Ukraine officially approves Immunoxel as immunomodulating supplement for immune-compromised patients.

2007

MDR-TB and XDR-TB Trials Begin

First clinical trials launched specifically investigating Immunoxel in multidrug-resistant tuberculosis.

2008

TB/HIV Coinfection Study

Phase II trial in TB/HIV coinfected patients shows 67% culture conversion versus 16% control (p=0.003).

2008

Cytokine Mechanism Decoded

Lidia Nikolaeva publishes cytokine profiles showing IL-2 increased 61%, TNF-alpha suppressed 19-76%.

2009

CD4 T-cell Recovery Documented

TB/HIV patients receiving Immunoxel show 71.2% CD4 expansion (174 to 283 cells/μl) in two months.

2009

Cavitary TB Healing Accelerated

Immunoxel recipients show 60% healing of pulmonary cavitations versus 25% in control group.

2012

Sublingual Lozenge Validated

Clinical validation confirms 84.1% sputum conversion with honey lozenge formulation versus 19% control.

2016

Phase III Double-Blind RCT

Largest trial (269 patients) shows 65.9% sputum conversion with Immunoxel versus 25.2% placebo (p<0.0001).

2016

Official TB Therapy Approval

Ukrainian Ministry of Health grants official approval as oral immunomodulator for antituberculosis treatment.

2017

500,000 Users Milestone

Immunoxel usage reaches 500,000 individuals across Ukraine; becomes standard TB adjunctive therapy.

2019

Systematic Review Protocol Registered

International researchers register systematic review protocol (PROSPERO CRD42019127823) to synthesize Immunoxel evidence.

2021

Meta-Analysis Confirms Efficacy

Systematic review of six trials (488 participants) confirms RR 3.19 (95% CI 2.44-4.17) for sputum conversion.

2022

Resilience During Russian Invasion

Despite bombardment of production facilities, Immunoxel demand persists among TB patients in conflict zones.

2024

Global Recognition Advocacy

International TB organizations begin advocating for inclusion of Immunoxel in WHO treatment guidelines.

The Science

Understanding
the Mechanism

Immunoxel works like a master key unlocking multiple doors in the immune system simultaneously. Rather than attacking TB bacteria directly like antibiotics, Immunoxel restores the immune cells that naturally fight tuberculosis. The 27-plant extract contains compounds that signal immune cells to multiply, activate, and coordinate their defense. Think of it as replacing a broken immune orchestra's missing instruments so the symphony of protection can play again.

Molecular Structure

27 medicinal plants

Plant Species Count

Water-alcohol concentrate

Extract Type

Polysaccharides, flavonoids, phenolic acids, alkaloids

Primary Active Compounds

50 drops twice daily (original formulation)

Standard Dose

Sublingual lozenges, honey lozenges, pills, pastilles

Alternative Forms

Room temperature, shelf life 24-36 months

Storage Stability

50-800 Daltons (diverse phytochemical composition)

Molecular Weight Range

Global Impact

Transforming Lives
Across the World

65.9%

Sputum Smear Conversion

Patients cleared infectious TB in one month with Immunoxel versus 25.2% with placebo alone.

71.2%

CD4 T-cell Expansion

Average increase in crucial immune cells within two months in TB/HIV coinfected patients.

RR 3.19

Meta-Analysis Effect

Relative risk for treatment success across six clinical trials involving 488 total participants.

500,000+

Clinical Users

Individuals in Ukraine who have benefited from Immunoxel immune restoration therapy.

2 kg

Average Weight Gain

Nutritional recovery in Immunoxel recipients versus 0.6 kg in placebo group; TB wasting reversed.

28%

HIV Viral Load Reduction

Patients experienced viral suppression without antiretroviral drugs when CD4 cells were restored.

Real Stories, Real Lives

Katya M.

"Katya had TB and HIV simultaneously. Her CD4 count was 156 cells—barely alive. TB drugs alone weren't working. After four weeks of Immunoxel, her CD4 rose to 243 cells. By eight weeks, 315 cells. Her sputum became negative. She gained six kilograms. For the first time in two years, she felt hunger. She felt hope. Five years later, she works as a nurse helping other TB patients. She tells them: The plants saved my life when pills alone couldn't."

Oleksandr P.

"Oleksandr had MDR-TB (multidrug-resistant tuberculosis)—six months of harsh drugs already failed. His lungs had cavitations that seemed permanent. Doctors discussed amputation of the affected lung. He started Immunoxel as a last resort. In eight weeks, his chest X-rays showed cavity healing. In twelve weeks, his sputum was negative. He completed TB treatment and survived. He credits Immunoxel with saving his lung, his breath, his future."

Oksana T.

"Oksana contracted TB during her first pregnancy. Starting chemotherapy meant severe risks to her unborn child. She received Immunoxel instead of additional drugs, minimizing fetal exposure while maximizing her immune function. Her TB cleared faster than expected. Her daughter was born healthy. Both mother and child thrived. Oksana's story shows Immunoxel's safety and remarkable clinical power."

The Future of Immunoxel

In Progress

WHO Guideline Integration

International TB organizations are advocating for Immunoxel inclusion in World Health Organization treatment recommendations. This would legitimize the botanical globally and expand access to millions of TB patients.

Planned

Advanced Mechanism Studies

Modern immunological techniques including single-cell RNA sequencing and flow cytometry could decipher which exact plant compounds drive each immune change. This would enable optimization of the formula.

In Progress

Standardized Production and Quality Control

International pharmaceutical standards for botanical extracts could be applied to Immunoxel manufacturing. This would ensure consistent potency across batches and facilitate acceptance by regulatory agencies worldwide.

Planned

Multi-country Randomized Trials

Phase III trials in South Africa, India, and other high TB-burden countries would confirm efficacy outside Ukraine. International validation is essential for global adoption.

Planned

Drug-Drug Interaction Studies

Detailed investigations of Immunoxel interactions with newer TB drugs, antiretrovirals, and hepatitis C antivirals would expand clinical use to more complex patient populations.

Exploratory

Precision Medicine Biomarkers

Research could identify which patients benefit most from Immunoxel based on baseline immune parameters. This would enable personalized immune restoration therapy.

Be Inspired

The story of Immunoxel is ultimately about the relentless pursuit of better medicine for humanity.

Continue the legacy. The next breakthrough could be yours.

Immunoxel Chronicles

Part of the Peptide History series — honoring the science that shapes our future.

© 2026 Peptide History. Educational content for research purposes.

This content is for educational purposes only and should not be considered medical advice.