Think of insulin as a key and your cells as locked doors. Normally, insulin unlocks your cells so glucose (sugar from food) can enter and provide energy. In Type 2 Diabetes, those locks get rusty - your cells become resistant to insulin's signal.
Your pancreas responds by making more insulin (louder knocking), but eventually it can't keep up. The result? Glucose builds up in your bloodstream while your cells starve for energy. Meanwhile, chronically high blood sugar damages blood vessels, nerves, kidneys, and eyes.
"Your cells have food outside the door but can't let it in."
The breakthrough came when scientists discovered that certain gut hormones - called incretins - could help restore this broken communication system. GLP-1 peptides don't just lower blood sugar; they address multiple aspects of metabolic dysfunction simultaneously.