Peptide Comparison
VilonvsLL-37
Immunomodulatory dipeptide bioregulator (Lys-Glu) that upregulates SIRT1 expression 6-fold through direct DNA promoter binding, activates T-cell differentiation via sphingomyelin signaling, and reduces pro-inflammatory cytokines by up to 6-fold as a natural inducer of TNF tolerance
Human cathelicidin-derived antimicrobial peptide (37 amino acids) that disrupts bacterial membranes at MIC 0.62 μM against S. aureus, neutralizes endotoxin (LPS) to prevent septic shock, and has reached Phase II clinical trials as Ropocamptide for wound healing — achieving 6-fold accelerated healing at 0.5 mg/mL in venous leg ulcers
At a Glance
Quick
comparison
Dose Range
Vilon
5–10 mg
LL-37
0.5–1.6 mg/mL (topical)
Frequency
Vilon
Once daily
LL-37
Once daily
Administration
Vilon
Subcutaneous injection
LL-37
Topical application (wound healing)
Cycle Length
Vilon
12+ weeks
LL-37
12+ weeks
Onset Speed
Vilon
Gradual (3-4 weeks)
LL-37
Moderate (1-2 weeks)
Evidence Level
Vilon
Limited human trials
LL-37
Moderate human trials (Phase 1-2)
Efficacy
Benefit
ratings
Immune System Revival
Healthy Aging
Digestive Support
Wound Healing
Fighting Infections
Immune Boost
Technical Data
Compound
specifications
Vilon
Molecular Formula
C11H21N3O5
Molecular Weight
275.3 g/mol
Half-Life
Short plasma half-life typical of dipeptides (minutes); biological effects persist for weeks to months through epigenetic modifications to SIRT1/PARP gene expression; metabolized to constituent amino acids
Bioavailability
Absorbed via intestinal peptide transporters (PepT1) when administered orally (demonstrated in animal studies); rapid absorption from subcutaneous injection sites; efficient cellular uptake and nuclear penetration due to ultra-short dipeptide structure
CAS Number
45234-02-4
LL-37
Molecular Formula
C205H340N60O53
Molecular Weight
4,493.26 Da
Half-Life
Short systemic half-life (minutes) due to protease susceptibility; local tissue persistence at wound sites is longer due to binding to extracellular matrix components and lipid membranes
Bioavailability
Topical application achieves high local wound-bed concentrations; systemic bioavailability limited by rapid proteolytic degradation and serum protein binding; not intended for oral delivery
CAS Number
154947-66-7
Protocols
Dosing
tiers
Vilon
LL-37
Applications
Best
suited for
Vilon
Immune system restoration in aging individuals with declining thymic function
Vilon is particularly well-suited for individuals focused on immune system restoration in aging individuals with declining thymic function. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Adjunctive immunomodulatory support during cancer treatment protocols
Vilon is particularly well-suited for individuals focused on adjunctive immunomodulatory support during cancer treatment protocols. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Geroprotective therapy targeting SIRT1/PARP pathways for cellular longevity
Vilon is particularly well-suited for individuals focused on geroprotective therapy targeting sirt1/parp pathways for cellular longevity. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Comprehensive Khavinson bioregulator protocols for anti-aging and immune support
Vilon is particularly well-suited for individuals focused on comprehensive khavinson bioregulator protocols for anti-aging and immune support. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
LL-37
Treatment of chronic non-healing wounds including venous leg ulcers and diabetic ulcers
LL-37 is particularly well-suited for individuals focused on treatment of chronic non-healing wounds including venous leg ulcers and diabetic ulcers. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Immune defense against antibiotic-resistant bacterial infections (MRSA, Pseudomonas)
LL-37 is particularly well-suited for individuals focused on immune defense against antibiotic-resistant bacterial infections (mrsa, pseudomonas). Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Anti-biofilm strategies for chronic wound infections and medical device-associated infections
LL-37 is particularly well-suited for individuals focused on anti-biofilm strategies for chronic wound infections and medical device-associated infections. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Boosting innate immune defense in immunocompromised or aging individuals
LL-37 is particularly well-suited for individuals focused on boosting innate immune defense in immunocompromised or aging individuals. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.
Safety Profile
Side
effects
Vilon
Common
- Injection site reaction
- Mild fatigue
- Mild headache
- Digestive changes
Uncommon
- Flu-like symptoms
Serious
- No documented serious adverse effects
LL-37
Common
- Local site irritation
- Transient stinging or burning
- Mild perilesional erythema
- Increased wound exudate
Uncommon
- Allergic contact reaction
Serious
- Hemolytic activity at systemic concentrations
Research Status
Safety
& evidence
Vilon
Evidence Level
Limited human trials
FDA Status
Research compound
Safety Overview
Vilon (immunomodulatory thymic peptide complex from bovine thymus) demonstrates favorable safety in Russian/Eastern European medical use over 20+ years with minimal documented serious adverse events in published literature. Bovine-derived peptide preparations carry theoretical prion disease risk (variant Creutzfeldt-Jakob disease) though processing methods and regulatory standards substantially reduce this risk. Common adverse effects are mild—local injection site reactions, transient fever, or lymphadenopathy—consistent with immune system stimulation rather than toxicity.
Contraindications
- xKnown hypersensitivity to peptide bioregulators or constituent amino acids (lysine, glutamic acid)
- xPregnancy and breastfeeding — insufficient reproductive safety data
- xActive autoimmune disease in flare without medical supervision
- xOrgan transplant recipients on immunosuppression — potential interference with immunosuppressive regimens
LL-37
Evidence Level
Moderate human trials (Phase 1-2)
FDA Status
Research compound
Safety Overview
LL-37 is an endogenous cathelicidin antimicrobial peptide naturally produced by immune cells and epithelial tissues, conferring inherent biocompatibility and low toxicity at physiological concentrations. Synthetic LL-37 shows excellent safety in in vitro immune assays and animal models with no hepatotoxicity, nephrotoxicity, or genotoxicity at relevant doses. At elevated concentrations, the cationic amphipathic structure can cause hemolysis and cell membrane damage, but therapeutic doses are far below these thresholds. Injection site reactions are minimal in research applications.
Contraindications
- xKnown hypersensitivity to cathelicidin peptides or formulation components
- xActive hemolytic conditions — LL-37 demonstrates concentration-dependent hemolytic activity
- xPregnancy and breastfeeding — insufficient reproductive safety data from clinical trials
- xSevere renal impairment — peptide clearance may be altered
Decision Guide
Which is
right for you?
Choose Vilon if...
- Immune system restoration in aging individuals with declining thymic function
- Adjunctive immunomodulatory support during cancer treatment protocols
- Geroprotective therapy targeting SIRT1/PARP pathways for cellular longevity
- Comprehensive Khavinson bioregulator protocols for anti-aging and immune support
Choose LL-37 if...
- Treatment of chronic non-healing wounds including venous leg ulcers and diabetic ulcers
- Immune defense against antibiotic-resistant bacterial infections (MRSA, Pseudomonas)
- Anti-biofilm strategies for chronic wound infections and medical device-associated infections
- Boosting innate immune defense in immunocompromised or aging individuals