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Weight Management
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Weight Management
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Tesamorelin
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Total Peptides: 32
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Peptide Comparison

GanirelixvsGonadorelin (GnRH)

Fast-acting GnRH antagonist that stops premature ovulation during fertility treatment

The master hormone that controls your reproductive system and fertility

Hormone SupportHormone Support

At a Glance

Quick
comparison

Dose Range

Ganirelix

250 mcg–500 mcg micrograms

Gonadorelin (GnRH)

0.1-1.5–3-10 mg

Frequency

Ganirelix

Once daily

Gonadorelin (GnRH)

Once daily

Administration

Ganirelix

Subcutaneous injection

Gonadorelin (GnRH)

Subcutaneous injection

Cycle Length

Ganirelix

Ongoing/indefinite

Gonadorelin (GnRH)

Ongoing/indefinite

Onset Speed

Ganirelix

Moderate (1-2 weeks)

Gonadorelin (GnRH)

Moderate (1-2 weeks)

Evidence Level

Ganirelix

Strong human trials (Phase 3 or FDA approved)

Gonadorelin (GnRH)

Moderate human trials (Phase 1-2)

Efficacy

Benefit
ratings

Ganirelix
Gonadorelin (GnRH)

Ovulation Control

Ganirelix94%
Gonadorelin (GnRH)0%

IVF Success Improvement

Ganirelix90%
Gonadorelin (GnRH)0%

Safety & OHSS Prevention

Ganirelix87%
Gonadorelin (GnRH)0%

Reproductive Health

Ganirelix0%
Gonadorelin (GnRH)95%

Hormone Balance

Ganirelix0%
Gonadorelin (GnRH)90%

Ovulation Support

Ganirelix0%
Gonadorelin (GnRH)88%

Technical Data

Compound
specifications

Ganirelix

Molecular Formula

C80H113ClN18O13

Molecular Weight

1570.4 g/mol

Half-Life

10-12 hours

Bioavailability

~91% (subcutaneous injection)

CAS Number

124904-93-4

Gonadorelin (GnRH)

Molecular Formula

C55H75N17O13

Molecular Weight

1182.3

Half-Life

2-4 minutes

Bioavailability

Varies by route: ~5-20% (intranasal), 100% (IV/IM injections)

CAS Number

34973-08-5

Applications

Best
suited for

Ganirelix

Improving IVF or ICSI success rates

Ganirelix is particularly well-suited for individuals focused on improving ivf or icsi success rates. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.

Preventing premature ovulation during egg retrieval cycles

Ganirelix is particularly well-suited for individuals focused on preventing premature ovulation during egg retrieval cycles. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.

Controlling ovarian stimulation in women with unpredictable cycles

Ganirelix is particularly well-suited for individuals focused on controlling ovarian stimulation in women with unpredictable cycles. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.

Gonadorelin (GnRH)

Improving fertility and conception chances

Gonadorelin (GnRH) is particularly well-suited for individuals focused on improving fertility and conception chances. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.

Regulating irregular menstrual cycles

Gonadorelin (GnRH) is particularly well-suited for individuals focused on regulating irregular menstrual cycles. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.

Enhancing reproductive hormone levels

Gonadorelin (GnRH) is particularly well-suited for individuals focused on enhancing reproductive hormone levels. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.

Supporting natural pregnancy attempts

Gonadorelin (GnRH) is particularly well-suited for individuals focused on supporting natural pregnancy attempts. Research and clinical experience suggest meaningful benefits in this area when used as part of a comprehensive treatment approach.

Safety Profile

Side
effects

Ganirelix

Common

  • Mild discomfort at treatment site
  • Injection site reactions (redness, bruising, swelling)
  • Headaches
  • Abdominal pain
  • Pelvic discomfort
  • Nausea
  • Fatigue or dizziness

Serious

  • Severe allergic reaction

Gonadorelin (GnRH)

Common

  • Mild headache
  • Local injection site reactions (redness, swelling)
  • Temporary hot flashes
  • Mood changes or emotional sensitivity
  • Nausea or mild stomach upset
  • Allergic skin reactions
  • Dizziness or lightheadedness
  • Temporary changes in vision
  • Joint or muscle aches
  • Insomnia or sleep disturbances
  • Severe allergic reactions (difficulty breathing, swelling)
  • Severe hormonal imbalance symptoms
  • Ovarian hyperstimulation syndrome (OHSS)
  • Signs of blood clots (chest pain, leg swelling)
  • Severe mood changes or depression

Serious

  • Severe allergic reaction

Research Status

Safety
& evidence

Ganirelix

Evidence Level

Strong human trials (Phase 3 or FDA approved)

FDA Status

FDA approved for this use

Safety Overview

Ganirelix carries an excellent safety record from over 10,000 patients in FDA approval trials and 25+ years of clinical fertility practice. The antagonist mechanism avoids the flare effect seen with GnRH agonists, making it safer for women with diminished ovarian reserve. Injection site reactions are the most common issue (20-40% of patients), though typically mild bruising rather than systemic toxicity. The rapid 1-2 hour onset and quick clearance mean side effects resolve quickly if dosing is adjusted.

Contraindications

  • xPregnancy or suspected pregnancy
  • xBreastfeeding
  • xKnown allergies to any medication component
  • xOvarian cysts larger than 3cm

Gonadorelin (GnRH)

Evidence Level

Moderate human trials (Phase 1-2)

FDA Status

FDA approved for this use

Safety Overview

Gonadorelin is native GnRH and carries the safety profile established over 40+ years of clinical use in reproductive endocrinology. As the body's natural hormone, it produces minimal local side effects when dosed appropriately. The critical safety concern with gonadorelin is the initial flare effect within 24-48 hours of first dose—temporary elevation in FSH and LH—which can paradoxically suppress sex hormones before the desired stimulation occurs. This flare makes gonadorelin unsuitable for some conditions and explains why synthetic analogs (agonists, antagonists) are preferred in many modern fertility protocols.

Contraindications

  • xPregnancy or breastfeeding
  • xHormone-sensitive cancers (breast, prostate, ovarian)
  • xSevere pituitary or hypothalamic disease
  • xUndiagnosed abnormal vaginal bleeding
  • xKnown hypersensitivity to GnRH

Decision Guide

Which is
right for you?

Choose Ganirelix if...

  • Improving IVF or ICSI success rates
  • Preventing premature ovulation during egg retrieval cycles
  • Controlling ovarian stimulation in women with unpredictable cycles

Choose Gonadorelin (GnRH) if...

  • Improving fertility and conception chances
  • Regulating irregular menstrual cycles
  • Enhancing reproductive hormone levels
  • Supporting natural pregnancy attempts