Melanotan-2
MT-II, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
Melanotan-2 (MT-II) is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) that acts as a non-selective melanocortin receptor agonist. Originally developed for skin pigmentation research, it has also been investigated for erectile dysfunction. NOT FDA approved and carries significant safety warnings from health agencies worldwide due to serious adverse effects including potential melanoma risk.
Complete Dosing Guide
Special Considerations
Mechanism of Action:
- Melanocortin Receptor Activation: Non-selective agonist of MC1R, MC3R, MC4R, and MC5R receptors.
- MC1R (Skin): Stimulates melanocytes to produce eumelanin, resulting in skin darkening and photoprotection.
- MC3R & MC4R (Brain): Regulates appetite, energy expenditure, sexual function, and metabolic processes.
- MC4R (Central Nervous System): Produces sexual arousal, spontaneous erections, and appetite suppression.
- MC5R (Exocrine Glands): May influence sebum production and other glandular functions.
- Crosses Blood-Brain Barrier: Unlike many peptides, MT-2 can access the central nervous system, producing neurological effects.
Tanning Expectations:
- Initial darkening visible within 3-7 days with UV exposure
- Maximum effect typically achieved in 3-4 weeks
- Tan lasts significantly longer than natural sun tan (weeks to months)
- Freckles and existing moles will darken first
- Results vary by skin type - redheads produce different melanin variant (pheomelanin)
- Individual response varies greatly based on melanocyte density
Sexual Enhancement Effects:
- Effects typically peak 2-6 hours after injection
- Mean duration of erection >80% rigidity: 38 minutes (clinical study)
- 80% of men with psychogenic ED showed clinical response
- Effects in women include increased desire, arousal, and lubrication
- May cause spontaneous erections (priapism risk in rare cases)
Appetite Suppression & Weight Loss:
- Appetite suppression most noticeable in first 1-2 weeks
- Body adapts and hunger may return to baseline despite continued use
- Weight loss continues even after appetite normalization (via metabolic effects)
- Promotes conversion of white adipose tissue to brown/beige fat
- Increases UCP1 expression in brown adipose tissue (thermogenesis)
- May reduce both visceral and subcutaneous fat
Individual Variability:
- Skin type dramatically affects tanning response
- Melanocyte density varies between individuals
- Side effect sensitivity differs greatly
- Dose requirements vary by body weight and goals
- Start low and titrate based on individual response
Medical Disclaimer
CRITICAL WARNING: Melanotan-2 is NOT approved by the FDA or any major regulatory agency for human use. Health authorities worldwide have issued warnings against its use due to serious safety risks including potential melanoma, priapism, rhabdomyolysis, and systemic toxicity. This information is for educational and research purposes only. Any use requires medical supervision and carries significant legal and health risks. Consult healthcare providers for approved alternatives.