Melanotan-2
MT-II, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
Melanotan-2 (MT-II) is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) that acts as a non-selective melanocortin receptor agonist. Originally developed for skin pigmentation research, it has also been investigated for erectile dysfunction. NOT FDA approved and carries significant safety warnings from health agencies worldwide due to serious adverse effects including potential melanoma risk.
Complete Dosing Guide
Possible Side Effects
Common Side Effects (>10% of users):
- Nausea (18-38% of injections, especially in first week)
- Facial flushing and warmth
- Decreased appetite and early satiety
- Spontaneous yawning and stretching
- Fatigue and drowsiness (somnolence)
- Darkening of skin, moles, and freckles
- Injection site reactions (redness, tenderness)
- Temporary increased libido
- Spontaneous penile erections in men
Note: Gastrointestinal side effects are most common during initial dosing and typically improve within 1-2 weeks as the body adapts.
Less Common Side Effects (1-10% of users):
- Headache
- Dizziness or lightheadedness
- Abdominal discomfort or cramping
- Changes in bowel habits
- Increased sweating or diaphoresis
- Changes in mole appearance (size, color, shape)
- Development of new moles (eruptive nevi)
- Mild increase in blood pressure
- Restlessness or anxiety
- Sleep disturbances
Rare but Serious Side Effects (<1% of users):
- Melanoma or Skin Cancer: Unclear causal relationship, but case reports exist of melanoma developing during or after MT-2 use.
- Severe Cardiovascular Events: Sympathomimetic excess, severe hypertension, tachycardia.
- Priapism: Prolonged erections lasting >4 hours requiring emergency treatment.
- Rhabdomyolysis: Severe muscle breakdown leading to kidney damage (typically with overdose).
- Renal Infarction: Acute disruption of blood flow to kidneys.
- Posterior Reversible Encephalopathy Syndrome (PRES): Seizures, visual disturbances, confusion, severe headache.
- Severe Allergic Reactions: Difficulty breathing, throat swelling, severe rash, anaphylaxis.
- Severe Nausea/Vomiting: Leading to dehydration and electrolyte imbalance.
- Changes in Dysplastic Nevi: Transformation of existing atypical moles.
Overdose Symptoms:
High doses (>3 mg) or accidental overdose may cause:
- Severe nausea and vomiting
- Profuse sweating and diaphoresis
- Extreme anxiety and restlessness
- Muscle tremors and rigidity
- Rapid heart rate (tachycardia up to 146 bpm)
- Elevated blood pressure
- Mydriasis (dilated pupils)
- Potential for rhabdomyolysis and renal dysfunction
Medical Disclaimer
CRITICAL WARNING: Melanotan-2 is NOT approved by the FDA or any major regulatory agency for human use. Health authorities worldwide have issued warnings against its use due to serious safety risks including potential melanoma, priapism, rhabdomyolysis, and systemic toxicity. This information is for educational and research purposes only. Any use requires medical supervision and carries significant legal and health risks. Consult healthcare providers for approved alternatives.