Melanotan-2
MT-II, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
Melanotan-2 (MT-II) is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) that acts as a non-selective melanocortin receptor agonist. Originally developed for skin pigmentation research, it has also been investigated for erectile dysfunction. NOT FDA approved and carries significant safety warnings from health agencies worldwide due to serious adverse effects including potential melanoma risk.
Complete Dosing Guide
What is Melanotan 2?
Melanotan 2 (MT-2) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH). It's a potent melanocortin receptor agonist that activates multiple melanocortin receptors (MC1R, MC3R, MC4R, and MC5R) throughout the body. Unlike its linear predecessor Melanotan 1 (afamelanotide), Melanotan 2 has a shorter, more stable cyclic structure with broader receptor activity, making it effective at lower doses but also producing additional physiological effects beyond skin tanning.
Important Note: Melanotan 2 is not approved by the FDA or most regulatory agencies worldwide. It remains an unlicensed research peptide sold through unregulated channels. Health agencies in the US, UK, Australia, and many other countries have issued warnings against its use due to lack of comprehensive safety testing and regulatory approval.
When is Melanotan 2 Used?
Skin Tanning & Pigmentation:
- Stimulates melanin production for skin darkening with minimal UV exposure.
- Provides photoprotection by increasing the skin's natural defense against UV radiation.
- Creates more even, longer-lasting tan compared to natural sun exposure.
- Particularly beneficial for individuals with fair skin (Fitzpatrick types I-II) who burn easily.
Sexual Dysfunction & Libido Enhancement:
- Improves erectile function in men with psychogenic erectile dysfunction.
- Increases spontaneous erections and sexual arousal.
- Enhances libido and sexual desire in both men and women.
- Improves arousal, vaginal lubrication, and orgasmic intensity in women.
Weight Management & Appetite Suppression:
- Reduces appetite and promotes feelings of satiety.
- Increases energy expenditure and fat oxidation.
- Promotes lipolysis (fat breakdown) in adipose tissue.
- Converts white fat to metabolically active brown/beige fat.
- May support metabolic health and insulin sensitivity.
Other Potential Applications (Research Stage):
- Immune system modulation and anti-inflammatory effects.
- May reduce symptoms in autoimmune conditions.
- Potential benefits for alcohol use disorder and impulse control.
- May support neurological health and BDNF production.
Medical Disclaimer
CRITICAL WARNING: Melanotan-2 is NOT approved by the FDA or any major regulatory agency for human use. Health authorities worldwide have issued warnings against its use due to serious safety risks including potential melanoma, priapism, rhabdomyolysis, and systemic toxicity. This information is for educational and research purposes only. Any use requires medical supervision and carries significant legal and health risks. Consult healthcare providers for approved alternatives.