Melanotan-2
MT-II, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
Melanotan-2 (MT-II) is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) that acts as a non-selective melanocortin receptor agonist. Originally developed for skin pigmentation research, it has also been investigated for erectile dysfunction. NOT FDA approved and carries significant safety warnings from health agencies worldwide due to serious adverse effects including potential melanoma risk.
Complete Dosing Guide
What to Monitor
Skin Monitoring (Critical):
- Weekly self-examination of all moles and skin lesions
- Monthly photography documentation of suspicious lesions
- Professional dermatological examination every 3-6 months during use
- Monitor for: changes in mole size, shape, color, borders, or texture
- Watch for new mole development (eruptive nevi)
- Immediate evaluation of any concerning changes
- Discontinue use if suspicious changes occur
Cardiovascular Monitoring:
- Blood pressure checks before starting and weekly during use
- Monitor heart rate, especially during initial dosing
- Watch for signs of hypertension (headache, chest pain, shortness of breath)
- Seek medical attention if severe flushing or chest discomfort occurs
General Health Monitoring:
- Body weight measurements (if using for weight loss)
- Energy levels and physical performance
- Appetite and eating patterns
- Sexual function changes
- Mood and mental health status
- Signs of dehydration (especially with nausea)
Laboratory Monitoring (If Available):
- Baseline complete metabolic panel before starting
- Kidney function tests (creatinine, BUN)
- Liver function tests
- Consider repeat labs every 3-6 months with extended use
Emergency Symptoms Requiring Immediate Medical Attention:
- Priapism (erection lasting >4 hours)
- Severe chest pain or pressure
- Difficulty breathing or throat swelling
- Severe persistent headache with vision changes
- Signs of rhabdomyolysis (severe muscle pain, dark urine, weakness)
- Seizures or altered consciousness
- Rapid changes in mole appearance
Medical Disclaimer
CRITICAL WARNING: Melanotan-2 is NOT approved by the FDA or any major regulatory agency for human use. Health authorities worldwide have issued warnings against its use due to serious safety risks including potential melanoma, priapism, rhabdomyolysis, and systemic toxicity. This information is for educational and research purposes only. Any use requires medical supervision and carries significant legal and health risks. Consult healthcare providers for approved alternatives.