Melanotan-2
MT-II, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
Melanotan-2 (MT-II) is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) that acts as a non-selective melanocortin receptor agonist. Originally developed for skin pigmentation research, it has also been investigated for erectile dysfunction. NOT FDA approved and carries significant safety warnings from health agencies worldwide due to serious adverse effects including potential melanoma risk.
Complete Dosing Guide
Who Should Not Take Melanotan 2 & Safety Tips
Do Not Use If:
- Personal or family history of melanoma or skin cancer.
- Multiple dysplastic nevi or atypical moles.
- Familial Atypical Mole and Malignant Melanoma (FAMMM) syndrome.
- History of severe cardiovascular disease or uncontrolled hypertension.
- Pregnant or breastfeeding (safety not established).
- History of priapism or sickle cell disease.
- Severe psychiatric conditions or mood disorders.
- History of severe allergic reactions to peptides.
- Under 18 years of age.
Use Carefully If:
- You have numerous moles or freckles (monitor for changes).
- You have fair skin (Fitzpatrick type I) with history of sunburn.
- You have cardiovascular conditions (MT-2 may affect blood pressure).
- You have kidney disease (limited safety data).
- You take medications for erectile dysfunction (additive effects).
- You have a history of irregular moles or precancerous lesions.
- You have any autoimmune conditions.
Critical Safety Warnings:
Melanoma Risk:
- Several case reports link MT-2 use with melanoma development
- Unclear if MT-2 directly causes melanoma or if risk relates to UV-seeking behavior
- Can cause rapid darkening and changes to existing moles
- May mask early warning signs of skin cancer
- Regular dermatological monitoring essential if using
Mole & Skin Changes:
- Darkening of existing moles, freckles, and nevi
- Development of new moles (eruptive nevi)
- Changes to mole size, shape, or color
- Risk of atypical melanocytic nevi
- Melanonychia (nail discoloration)
- Can occur rapidly - within days to weeks
Cardiovascular Effects:
- May cause blood pressure changes
- Risk of sympathomimetic overstimulation at high doses
- Facial flushing and increased heart rate
- Use caution if history of cardiovascular disease
Contamination Risk:
- Unregulated products may contain impurities
- Risk of bacterial contamination in multi-use vials
- Unknown concentrations and peptide quality
- Improper reconstitution increases infection risk
- Sharing needles creates serious health risks
Drug Interactions:
- PDE5 Inhibitors (Viagra, Cialis): May have additive effects on erectile function and blood pressure.
- Blood Pressure Medications: MT-2 may affect blood pressure regulation.
- Appetite Suppressants: Additive effects on appetite reduction.
- Other Melanocortin Agonists: Avoid concurrent use.
Medical Disclaimer
CRITICAL WARNING: Melanotan-2 is NOT approved by the FDA or any major regulatory agency for human use. Health authorities worldwide have issued warnings against its use due to serious safety risks including potential melanoma, priapism, rhabdomyolysis, and systemic toxicity. This information is for educational and research purposes only. Any use requires medical supervision and carries significant legal and health risks. Consult healthcare providers for approved alternatives.