Kisspeptin
Kisspeptin-54 / Kisspeptin-10
Kisspeptin is a neuropeptide encoded by the KISS1 gene that plays a critical role in regulating the hypothalamic-pituitary-gonadal (HPG) axis. It stimulates gonadotropin-releasing hormone (GnRH) secretion by binding to the GPR54/Kiss1R receptor, making it essential for reproductive function, puberty onset, and fertility. Originally discovered as a metastasis suppressor in certain cancers, kisspeptin has emerged as a promising therapeutic target for reproductive disorders including infertility, hypothalamic amenorrhea, and hypoactive sexual desire disorder.
Complete Dosing Guide
Special Considerations
Gender Differences:
- Men respond to lower doses than women
- Women's response varies by menstrual cycle phase
- Most responsive during preovulatory phase
Age Considerations:
- Postmenopausal women may have altered response
- No specific dose adjustments needed for older adults
Metabolic Status:
- Response may be reduced in obesity
- Leptin levels can affect kisspeptin effectiveness
- Energy balance impacts reproductive axis sensitivity
Medical Disclaimer
Kisspeptin is in Phase 2 clinical trials for reproductive applications. This information is for educational purposes only and should not be construed as medical advice. Any clinical use should occur only under medical supervision in approved research or clinical settings.