Kisspeptin
Kisspeptin-54 / Kisspeptin-10
Kisspeptin is a neuropeptide encoded by the KISS1 gene that plays a critical role in regulating the hypothalamic-pituitary-gonadal (HPG) axis. It stimulates gonadotropin-releasing hormone (GnRH) secretion by binding to the GPR54/Kiss1R receptor, making it essential for reproductive function, puberty onset, and fertility. Originally discovered as a metastasis suppressor in certain cancers, kisspeptin has emerged as a promising therapeutic target for reproductive disorders including infertility, hypothalamic amenorrhea, and hypoactive sexual desire disorder.
Complete Dosing Guide
Possible Side Effects
Common Side Effects:
- Mild injection site reactions
- Transient headaches
- Temporary hot flashes (10-20% of patients)
- Light-headedness immediately after injection
Rare but Notable Effects:
- Temporary changes in appetite
- Altered glucose metabolism
- Changes in blood pressure (usually mild)
Laboratory Monitoring:
- No significant changes in liver or kidney function observed
- Blood counts remain stable
- Electrolytes unaffected
Medical Disclaimer
Kisspeptin is in Phase 2 clinical trials for reproductive applications. This information is for educational purposes only and should not be construed as medical advice. Any clinical use should occur only under medical supervision in approved research or clinical settings.