Kisspeptin
Kisspeptin-54 / Kisspeptin-10
Kisspeptin is a neuropeptide encoded by the KISS1 gene that plays a critical role in regulating the hypothalamic-pituitary-gonadal (HPG) axis. It stimulates gonadotropin-releasing hormone (GnRH) secretion by binding to the GPR54/Kiss1R receptor, making it essential for reproductive function, puberty onset, and fertility. Originally discovered as a metastasis suppressor in certain cancers, kisspeptin has emerged as a promising therapeutic target for reproductive disorders including infertility, hypothalamic amenorrhea, and hypoactive sexual desire disorder.
Complete Dosing Guide
What to Monitor
Hormone Levels:
- LH and FSH levels (peak 30-60 minutes post-injection)
- Testosterone in men, estradiol in women
- Check levels every 4-6 weeks initially
Clinical Response:
- Sexual desire and function improvements
- Menstrual cycle regularity in women
- Energy levels and mood changes
Timing Considerations:
- Effects last 17-144 minutes (half-life approximately 4 minutes)
- LH response continues for several hours
- Plan injections accordingly
Medical Disclaimer
Kisspeptin is in Phase 2 clinical trials for reproductive applications. This information is for educational purposes only and should not be construed as medical advice. Any clinical use should occur only under medical supervision in approved research or clinical settings.