Kisspeptin
Kisspeptin-54 / Kisspeptin-10
Kisspeptin is a neuropeptide encoded by the KISS1 gene that plays a critical role in regulating the hypothalamic-pituitary-gonadal (HPG) axis. It stimulates gonadotropin-releasing hormone (GnRH) secretion by binding to the GPR54/Kiss1R receptor, making it essential for reproductive function, puberty onset, and fertility. Originally discovered as a metastasis suppressor in certain cancers, kisspeptin has emerged as a promising therapeutic target for reproductive disorders including infertility, hypothalamic amenorrhea, and hypoactive sexual desire disorder.
Complete Dosing Guide
How to Take Kisspeptin
For Hormone Regulation and Sexual Health
Starting Dose:
- 0.3-1.0 nmol/kg (approximately 100 mcg for average adult)
- Note: This dose effectively stimulates LH and FSH release
Frequency:
- 1-2 times per week maximum
- Important: Daily administration can lead to receptor desensitization
- Bi-weekly dosing prevents tolerance development
Administration:
- Subcutaneous injection preferred
- Can also be administered intravenously in clinical settings
- Inject at the same time of day for consistency
Dose Escalation:
- Start with lower dose (0.3 nmol/kg)
- Can increase to 1.0 nmol/kg if well tolerated
- Maximum dose: 3.0 μg/kg (approximately 2.4 nmol/kg)
For IVF and Fertility Protocols
Egg Maturation Trigger:
- Single dose: 6.4-12.8 nmol/kg subcutaneous injection
- Administered 36 hours before egg retrieval
- Replaces traditional hCG trigger to reduce OHSS risk
Success Rates:
- 92% of patients achieved successful fertilization
- 40% biochemical pregnancy rate
- 23% clinical pregnancy rate
How to Take It:
- Single injection only - not repeated
- Must be timed precisely with IVF protocol
- Administered by fertility specialist
Dosing Calculators
Dose Calculator
Unit Converter
Quick Reference:
Medical Disclaimer
Kisspeptin is in Phase 2 clinical trials for reproductive applications. This information is for educational purposes only and should not be construed as medical advice. Any clinical use should occur only under medical supervision in approved research or clinical settings.