IGF-1 LR3
Long R3 Insulin-like Growth Factor-1
IGF-1 LR3 is a synthetic analog of human insulin-like growth factor 1, engineered with an arginine substitution at position 3 and 13 additional amino acids at the N-terminus. This 83-amino acid peptide exhibits reduced affinity for IGF-binding proteins, resulting in a prolonged half-life of 20-30 hours and approximately 3 times greater potency than native IGF-1. Currently investigational and not FDA-approved for human use.
Complete Dosing Guide
Possible Side Effects
Common Side Effects:
- Mild hypoglycemia (low blood sugar) symptoms
- Redness or swelling at injection site
- Temporary water retention
- Mild joint discomfort
- Increased appetite
- Feeling of muscle "fullness" or pumps
Less Common Side Effects:
- Headaches
- Fatigue or lethargy
- Mild nausea
- Joint pain or stiffness
- Numbness or tingling in extremities
- Fluid retention (especially when stacked with GH)
Rare but Serious Side Effects:
- Severe hypoglycemia (dizziness, confusion, loss of consciousness)
- Insulin resistance with prolonged use
- Organ enlargement (heart, intestines) with excessive doses
- Acromegaly symptoms (facial changes, joint pain, enlarged extremities)
- Tumor growth acceleration (in those with undiagnosed cancer)
Managing Side Effects:
- For hypoglycemia: Immediately consume fast-acting carbohydrates
- For injection site reactions: Rotate sites, use ice if needed, ensure sterile technique
- For water retention: Reduce sodium intake, ensure adequate hydration
- For any severe reactions: Discontinue use and consult healthcare provider immediately
Medical Disclaimer
IGF-1 LR3 is an investigational research compound not approved by the FDA for human therapeutic use. This information is provided for educational purposes only and should not be construed as medical advice. IGF-1 LR3 carries significant risks including severe hypoglycemia and potential tumor growth acceleration. Any use should only occur under strict medical supervision in approved research settings. Individuals with cancer history, diabetes, or other serious medical conditions should not use this compound.