DSIP
L-tryptophyl-L-alanyl-glycyl-glycyl-L-aspartyl-L-alanyl-L-seryl-glycyl-L-glutamic acid
DSIP is a naturally occurring nonapeptide identified in 1977 from rabbit cerebral venous blood, comprising nine amino acids in the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. This linear, hydrophilic peptide maintains its endogenous structure without synthetic modifications, making it ideal for sleep regulation research, stress response modulation, and central nervous system function studies in controlled experimental settings.
Complete Dosing Guide
How to Take DSIP
Standard Protocol for Sleep Enhancement
Starting Dose:
- 100 mcg injected subcutaneously once daily
- Note: This initial dose helps assess individual response and tolerance
Dose Range:
- Clinical studies have used 21.4 mcg/kg of body weight
- For a 150 lb (68 kg) person: approximately 1,500 mcg
- Common therapeutic range: 100-250 mcg per dose
- Some practitioners recommend 150 mcg for optimal results
Timing:
- Administer 1-3 hours before bedtime
- Best results when taken at consistent times
- Effects typically begin within 10-30 minutes
- Sleep pressure reported within 130 minutes
Frequency Options:
- Daily: For severe sleep disorders
- Every 3 days: For moderate sleep issues
- Once weekly: For mild sleep optimization or maintenance
Duration:
- Studies have safely used DSIP for up to 14 days continuously
- Longer-term use should include cycling periods
Alternative Dosing Approaches
Conservative Protocol:
- Start at 50 mcg once weekly
- Gradually increase dose and frequency
- Maximum: 150 mcg three times per week
- Used to prevent tolerance development
Intensive Protocol:
- 100-200 mcg daily for acute insomnia
- Duration: 5-7 consecutive days
- Follow with 5 doses every 48-72 hours
For Pain Management
- 30 mcg/kg body weight daily
- Administered for 5 consecutive days
- Followed by 5 injections every 48-72 hours
- Total treatment period: 2-3 weeks
For Substance Withdrawal
- Dosing similar to standard sleep protocol
- 100-200 mcg daily during acute withdrawal
- Rapid onset of action (within 10 minutes)
- Effects last approximately 3.5 hours per dose
- Continue until withdrawal symptoms subside
Dosing Calculators
Dose Calculator
Unit Converter
Quick Reference:
Medical Disclaimer
DSIP is an investigational research compound not approved by the FDA for human therapeutic use. This information is for educational purposes only and should not be construed as medical advice. Any use should occur only under medical supervision in approved research settings.