Kisspeptin
Kisspeptin-54 / Kisspeptin-10
Kisspeptin is a neuropeptide encoded by the KISS1 gene that plays a critical role in regulating the hypothalamic-pituitary-gonadal (HPG) axis. It stimulates gonadotropin-releasing hormone (GnRH) secretion by binding to the GPR54/Kiss1R receptor, making it essential for reproductive function, puberty onset, and fertility. Originally discovered as a metastasis suppressor in certain cancers, kisspeptin has emerged as a promising therapeutic target for reproductive disorders including infertility, hypothalamic amenorrhea, and hypoactive sexual desire disorder.
Complete Dosing Guide
What is Kisspeptin?
Kisspeptin is a neuropeptide hormone that acts as a master regulator of the reproductive system. It works by stimulating the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus, which then triggers the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. These hormones are essential for reproductive function in both men and women.
When is Kisspeptin Used?
Reproductive Hormone Regulation:
- Stimulates natural testosterone production in men
- Regulates ovulation and fertility in women
- Treats hypogonadotropic hypogonadism
Fertility Enhancement:
- Used in IVF protocols to trigger egg maturation
- Helps restore reproductive function in hypothalamic amenorrhea
- Supports treatment of delayed or absent puberty
Sexual Health:
- Addresses hypoactive sexual desire disorder (HSDD)
- Improves sexual brain processing and arousal
- Clinical trials show 56% improvement in sexual response for men with low libido
Medical Disclaimer
Kisspeptin is in Phase 2 clinical trials for reproductive applications. This information is for educational purposes only and should not be construed as medical advice. Any clinical use should occur only under medical supervision in approved research or clinical settings.